检索结果-南通市图书馆

Immune tolerance Therapy： A New Method for Treatment of Traumatic Brain Injury

在线全文

学校读者我要写书评

暂无评论

Chinese Medical Journal 2018年第16期131卷 1990-1998页

作者： Ruo-Yang Feng Qian Chen Wei-Jian Yang Xiao-Guang Tong Zhi-Ming Sun Hua Yan Department of Neurosurgery Tianjin Medical University Tianjin 300070 China Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Diseases Tianjin 300350 China Department of Neurosurgery Tianjin Huanhu Hospital Tianjin 300350 China Department of Spine Surgery Tianjin Huanhu Hospital Tianjin 300350 China

Objective： Due to the special anatomical structure and pathophysiological mechanism of the central nervous system （CNS）, there is a big difference between the repair of brain injury and other systems of the body. More and more evidence shows that targetedly reducing the autoimmune response of brain tissue without affecting the immune function in other parts of the body will be the best optimized treatment for brain injury. Data Sources： This review was based on data in articles published in PubMed up to June 5,2017, with the following keywords：＂Immune tolerance＂, ＂traumatic brain injury＂, and ＂central nervous system＂. Study Selection： Original articles and critical reviews on Immune tolerance and brain damage were selected for this review. References of the retrieved articles were also screened to search for potentially relevant papers. Results： The CNS is isolated from the immune system through the blood-brain barrier. After brain injury, brain antigens are released into the systemic circulation to induce damaging immune responses. Immune tolerance can effectively reduce the brain edema and neurological inflammatory response after brain injury, which is beneficial to the recovery of neurological function. The clinical application prospect and theoretical research value of the treatment of Immune tolerance on traumatic brain inj ury （TBi） is worth attention. Conclusions： The establishment of Immune tolerance mechanism has a high clinical value in the treatment of TBI. It opens up new opportunities for the treatment of brain damage.

关键词： Central Nervous System Immune tolerance Traumatic Brain Injury

Transcriptional and epigenetic regulation of Immune tolerance:roles of the NF-κB family members

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2019年第4期16卷 315-323页

作者： Lei Zhang Xiang Xiao Preston R.Arnold Xian C.Li Immunobiology and Transplant Science Center and Department of Surgery Houston Methodist HospitalHoustonTXUSA Department of Surgery Weill Cornell Medical CollegeCornell UniversityNew YorkNYUSA

Immune tolerance is a highly regulated state and involves diverse mechanisms.Central to the induction of tolerance is the targeted modulation of T-cell activities(both effector and regulatory),in which transcription factors play a significant role.The nuclear factor kappa-B(NF-κB)family is a family of transcription factors that not only are critically involved in diverse T-cell responses but also are regulated by many mechanisms to maintain tolerance and T-cell homeostasis.NF-κB,as a transcription factor,has been extensively studied in recent decades,and the molecular mechanisms that regulate NF-κB activities have been well documented.However,recent studies have revealed exciting new roles for NF-κB;in addition to its transcriptional activity,NF-κB can also activate diverse epigenetic mechanisms that mediate extensive chromatin remodeling of target genes to regulate T-cell activities.In this review article,we highlight recent discoveries and emerging opportunities in targeting NF-κB family members as well as their associated chromatin modifiers in the induction of Immune tolerance and in the clinical treatment of immune diseases.

关键词： Immune tolerance NF-κB chromatin modifiers

Complex regulatory effects of gut microbial short-chain fatty acids on Immune tolerance and autoimmunity

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2023年第4期20卷 341-350页

作者： Chang H.Kim Department of Pathology University of Michigan School of MedicineAnn ArborMI48109USA Mary H.Weiser Food Allergy Center Center for Gastrointestinal Researchand Rogel Center for Can

Immune tolerance deletes or suppresses autoreactive lymphocytes and is established at multiple levels during the development,activation and effector phases of T and B cells.These mechanisms are cell-intrinsically programmed and critical in preventing autoimmune diseases.We have witnessed the existence of another type of Immune tolerance mechanism that is shaped by lifestyle choices,such as diet,microbiome and microbial metabolites.Short-chain fatty acids(SCFAs)are the most abundant microbial metabolites in the colonic lumen and are mainly produced by the microbial fermentation of prebiotics,such as dietary fiber.This review focuses on the preventive and immunomodulatory effects of SCFAs on autoimmunity.The tissue-and disease-specific effects of dietary fiber,SCFAs and SCFA-producing microbes on major types of autoimmune diseases,including type I diabetes,multiple sclerosis,rheumatoid arthritis and lupus,are discussed.Additionally,their key regulatory mechanisms for lymphocyte development,tissue barrier function,host metabolism,immunity,autoantibody production,and inflammatory effector and regulatory lymphocytes are discussed.The shared and differential effects of SCFAs on different types and stages of autoimmune diseases are discussed.

关键词： Short-chain fatty acids Immune tolerance Diabetes mellitus Rheumatoid arthritis Lupus Multiple sclerosis

Immune tolerance induced by immune-homeostatic particles

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineered Regeneration

Engineered Regeneration 2021年第1期2卷 133-136页

作者： Guopu Chen Hui Zhang Huan Wang Fengyuan Wang Institute of Translational Medicine The Affiliated Drum Tower Hospital of NanjingUniversity Medical SchoolNanjing210008China Department of Dermatology Zhongda HospitalSoutheast UniversityNanjing210009China The Eighth Affiliated Hospital of Sun Yat-sen University Shenzhen518033China

Autoimmune diseases,induced by dysfunction of the adaptive immune system,are the common disease categories worldwide.Recently,regulatory T cells(Tregs)enhancing therapies have been demonstrated to treat autoimmune diseases,which could induce Immune tolerance to protect cells and tissues from self-attacking of the immune system.However,their widespread application is limited by complex manufacturing process,long production period and high cost.Herein,we give a perspective of immune-homeostatic particles as immune regulators to induce antigen-specific Tregs for treating autoimmune diseases.Disease-specific autoantigen is loaded into the particle to induce Tregs differentiation after release.In addition,the surface of the particles is decorated by specific ligands that could bind and trigger apoptosis of activated T cells,thereby impressing the overreacted immune system.Furthermore,liver sinusoidal endothelial cells(LSEC)-targeting particles are developed to stimulate CD4^(+)T cells differentiation into Tregs.We believe that the immune-homeostatic particles have great potential in autoimmune diseases treatment and are valuable in various immune-related disease treatments.

关键词： Autoimmune disease Immune tolerance immune-homeostatic particle Regulatory T cell Immunomodulator

Histone methyltransferase Nsd2 ensures maternal-fetal Immune tolerance by promoting regulatory T-cell recruitment

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2022年第5期19卷 634-643页

作者： Le Zhang Xuehui Long Yuye Yin Jun Wang Huamin Zhu Jingjing Chen Yuliang Wang Yun Chen Xiaoming Wang Department of Immunology State Key Laboratory of Reproductive MedicineNHC Key Laboratory of Antibody TechniqueNanjing Medical UniversityNanjingJiangsuChina Analysis Center Nanjing Medical UniversityNanjingJiangsuChina Department of Immunology Key Laboratory of Immune Microenvironment and DiseaseNanjing Medical UniversityNanjingJiangsuChina State Key Laboratory of Reproductive Medicine Department of Prenatal DiagnosisWomen’s Hospital of Nanjing Medical UniversityNanjing Maternity and Child Health HospitalNanjing Medical UniversityNanjingJiangsuChina

Regulatory T cells(Tregs)are fundamentally important for maintaining systemic immune homeostasis and are also required for Immune tolerance at the maternal-fetal interface during pregnancy.Recent studies have suggested that epigenetic regulation is critically involved in Treg development and function.However,the role of H3K36me has not yet been investigated.Here,we found that the H3K36me2 methyltransferase Nsd2 was highly expressed in Tregs.Although loss of Nsd2 did not impair systemic Treg development or function,the level of Tregs at the maternal-fetal interface was significantly decreased in pregnant Nsd2 conditional knockout mice.Consequently,maternal-fetal Immune tolerance was disrupted in the absence of Nsd2 in Tregs,and the pregnant mice showed severe fetal loss.Mechanistically,Nsd2 was found to upregulate CXCR4 expression via H3K36me2 modification to promote Treg cell recruitment into the decidua and suppress the anti-fetal immune response.Overall,our data identified Nsd2 as a critical epigenetic regulator of Treg recruitment for maternal-fetal tolerance.

关键词： Regulatory T cell Cell migration Immune tolerance

An experimental study on thymus Immune tolerance to treat surgical brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2014年第4期127卷 685-690页

作者： Zheng Yongtao Kang Jianmin Liu Baolong Fan Weijia Wu Qiaoli Yan Hua Graduate School of Tianjin Medical University Tianjin 300070China Tianjin Cerebral Vascular and Neural Degenerative Disease Key Laboratory Department of Neurosurgery Tianjin Huanhu HospitalTianjin 300060 China

Background Many researches demonstrate that the secondary brain injury which is caused by autoimmune attack toward brain antigens plays an important role in surgical brain injury （SBI）.Although traditional immunosuppression can reduce autoimmune attack,it will lower the body immunity.Immune tolerance,by contrast,not only does not lower the body immunity,but also could lighten autoimmunity.This study used thymus tolerance to develop an immune system that is tolerant to autologous cerebrospinal fluid （CSF） and autologous brain tissue so that autoimmune injury can be suppressed following the disruption of the blood-brain barrier,thereby reducing brain damage.Methods Eighty experimental rabbits were divided into five groups by random number table method：16 in SBI group （group A）,16 in SBI＋CSF drainage group （group B）,16 in SBI＋CSF drainage＋PBS injection group （group C）,16 in SBI＋CSF drainage＋CSF intrathymic injection group （group D）,and 16 in SBl＋brain homogenate intrathymic injection group （group E）.Rabbits＆#39; CSF was drained in group B; was drained and injected PBS into thymus in group C; was drained and injected CSF into thymus in group D; and was injected brain homogenate in group E.Half of the rabbits in each group were phlebotomized on 1st,3rd,7th,and 14th days to observe the changes in IL-I,TGF-β by ELISA test,and CD4CD25 regulatory T cells ratio by flow cytometry,and in other animals brain tissues were taken on 7th day for exploring FasL expression by RT-PCR.The least significant difference （LSD） test was used to make paired comparisons; P ＜0.05 was considered statistically significant.Results The levels of FasL,TGF-β,and the ratios of CD4CD25 regulatory T cells in groups D and E were apparently higher than those in other three groups （P ＜0.05）.Likewise,the levels of IL-1 in these two groups were lower than the other three groups （P ＜0.05）.Moreover,the ratios of CD4CD25 regulatory T cells and the levels of TGF-β in groups B and C were higher than those in group A,but the level of IL-1 was lower than that in

关键词： brain injuries Immune tolerance regulatory T cells

Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of Immune tolerance

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2022年第8期14卷 599-615页

作者： Xiao-Yan Huang Zhan-Kui Jin Meng Dou Bing-Xuan Zheng Xiang-Rong Zhao Qing Feng Yang-Meng Feng Xiang-Long Duan Pu-Xun Tian Cui-Xiang Xu Shaanxi Provincial Key Laboratory of Infection and immune Diseases Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina Department of Orthopedics Shaanxi Provincial People’s HospitalXi'an 710068Shaanxi ProvinceChina Department of Kidney Transplantation The First Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710061Shaanxi ProvinceChina Second Department of General Surgery Shaanxi Provincial People's HospitalXi'an 710068Shaanxi ProvinceChina

BACKGROUND Immature dendritic cells(imDCs)play an important role in the induction of donor-specific transplant immunotolerance.However,these cells have limitations,such as rapid maturation and a short lifespan in vivo.In previous studies,induced pluripotent stem cells(iPSCs)differentiated into imDCs,and sinomenine(SN)was used to inhibit the maturation of imDCs.AIM To study the capacity of SN to maintain iPSC-derived imDCs(SN-iPSCs-imDCs)in an immature state and the mechanism by which SN-iPSCs-imDCs induce immunotolerance.METHODS In this study,mouse iPSCs were induced to differentiate into imDCs in culture medium without or with SN(iPSCs-imDCs and SN-iPSCs-imDCs).The imDCrelated surface markers,endocytotic capacity of fluorescein isothiocyanate Dextran and apoptosis were analyzed by flow cytometry.The effects of iPSCs-imDCs and SNiPSCs-imDCs on T-cell stimulatory function,and regulatory T(Treg)cell proliferative function in vitro were analyzed by mixed lymphocyte reaction.Cytokine expression was detected by ELISA.The apoptosis-related proteins of iPSCs-DCs and SN-iPSCs-DCs were analyzed by western blotting.The induced immunotolerance of SN-iPSCs-DCs was evaluated by treating recipient Balb/c skin graft mice.Statistical evaluation of graft survival was performed using Kaplan–Meier curves.RESULTS Both iPSCs-imDCs and SN-iPSCs-imDCs were successfully obtained,and their biological characteristics and ability to induce immunotolerance were compared.SN-iPSCs-imDCs exhibited higher CD11c levels and lower CD80 and CD86 levels compared with iPSCs-imDCs.Reduced major histocompatibility complex II expression,worse T-cell stimulatory function,higher Treg cell proliferative function and stronger endocytotic capacity were observed with SN-iPSCs-imDCs(P<0.05).The levels of interleukin(IL)-2,IL-12,interferon-γin SN-iPSCs-imDCs were lower than those in iPSCs-imDCs,whereas IL-10 and transforming growth factor-βlevels were higher(P<0.05).The apoptosis rate of these cells was significantly higher(P<0.05),and the expression levels of

关键词： Immature dendritic cells Induced pluripotent stem cells Sinomenine Immune tolerance Organ transplantation

Increased leakage of brain antigens after traumatic brain injury and effect of Immune tolerance induced by cells on traumatic brain injury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2012年第9期125卷 1618-1626页

作者： YAN Hua ZHANG Hong-wei WU Qiao-li ZHANG Guo-bin LIU Kui ZHI Da-shi HU Zhen-bo ZENG Xian-wei Department of Neurosurgery Tianjin Huanhu Hospital Tianjin 300070 China Department of Neurosurgery Second Hospital of Tianjin Medical University Tianjin 300070 China Department of-Neurosurgery Tianjin l eople＇s Hospital Tianjin 300070 China Department of Stem Cell Research and Transplantation Center Affiliated Hospital of Weifang Medical College Weifang Shandong 261053 China Department of Neurosurgery Affiliated Hospital of Weifang Medical College Weifang Shandong 261053 China

Background Although traumatic brain injury can lead to opening the blood-brain barrier and leaking of blood substances （including water） into brain tissue, few studies of brain antigens leaking into the blood and the pathways have been reported. Brain antigens result in damage to brain tissues by stimulating the immune system to produce anti-brain antibodies, but no treatment has been reported to reduce the production of anti-brain antibodies and protect the brain tissue. The aim of the study is to confirm the relationship between immune injury and arachnoid granulations following traumatic brain injury, and provide some new methods to inhibit the immune injury.Methods In part one, methylene blue was injected into the rabbits’ cisterna magna after traumatic brain injury, and concentrations of methylene blue and tumor necrosis factor （TNF）-α in blood were detected to determine the permeability of arachnoid granulations. In part two, umbilical cord mesenchymal stem cells and immature dendritic cells were injected into veins, and concentrations of interleukin 1 （IL-1）, IL-10, interferon （IFN）-γ, transforming growth factor （TGF）-β, anti-brain antibodies （ABAb）, and IL-12 were measured by ELISA on days 1, 3, 7, 14 and 21 after injury, and the numbers of leukocytes in the blood were counted. Twenty-one days after injury, expression of glutamate in brain tissue was determined by immunohistochemical staining, and neuronal degeneration was detected by H＆E staining. Results In part one, blood concentrations of methylene blue and TNF-α in the traumatic brain injury group were higher than in the control group （P 〈0.05）. Concentrations of methylene blue and TNF-α in the trauma cerebrospinal fluid （CSF） injected group were higher than in the control cerebrospinal fluid injected group （P 〈0.05）. In part two, concentrations of IL-1, IFN-γ, ABAb, IL-12, expression of glutamate （Glu）, neuronal degeneration and number of peripheral blood leukocytes were lower in the group with cell treatment compared to the control group. IL

关键词： traumatic brain injury stem cell antigen dendritic cell Immune tolerance

针刺对超排卵大鼠RT-BM1及母胎免疫耐受的影响

在线全文

学校读者我要写书评

暂无评论

World Journal of Acupuncture-Moxibustion 2024年第1期34卷 24-30页

作者：张金民徐梦浩许啸虎郑翠红华中科技大学同济医学院附属同济医院中西医结合研究所武汉430030

Objective:This study aimed to evaluate the effects of acupuncture on embryo implantation and maternal–fetal Immune tolerance in rats with ovarian hyperstimulation,identify the mechanisms of acupuncture treatment,and promote application of acupuncture in the field of assisted reproduction.Methods:Eighty female Wistar rats were randomized into normal(N),model(M),acupuncture treatment(A),and progesterone treatment(P)groups,with 20 rats in each group.An ovarian hyperstimulation model was established in groups M,A,and P by the peritoneal injection of pregnant mare serum gonadotropin(PMSG)combined with human chorionic gonadotropin(HCG).Bilateral“Sanyinjiao(SP6)”,“Zusanli(ST36)”and“Taichong(LR3)”as acupoints were needled in rats in group A.Rats in group P received an intramuscular injection of progesterone(4 mg/kg).All pregnant rats were treated for seven days.On the 8th day,the pregnant rats were sacrificed for testing.The expression levels of estrogen(E2)and progesterone(P4)in serum and their receptors in the endometrium,Th1 and Th2 cytokines in serum and endometrium,RT-BM1(the counterpart of HLA-G in rats)mRNA,Ly49 activating receptors(Ly49s3,Ly49s5)and inhibitory receptors(Ly49i3,Ly49i4,Ly49i5)on immunocytes in the maternal–fetal interface were detected using ELISA,Western blot,and real-time polymerase chain reaction(PCR).Results:Compared with group N,the pregnancy rate and the number of implanted embryos were significantly decreased in group M(P<0.05);E2 and P4 levels in serum,and the protein levels of ER-αand Progesterone Receptor(PGR)in the implantation site of endometrial tissue were significantly reduced in group M(P<0.05);the expression of INF-γand IL-2 in serum and endometrium were significantly increased,while the expression of IL-4,IL-6,and IL-10 in serum and endometrium were significantly decreased in group M(P<0.05).The mRNA levels of RT-BM1,Ly49i3,and Ly49i4 receptors in group M were significantly higher than those in group N,whereas the mRNA levels of Ly49i5 and Ly49s5 receptors in group M were signific

关键词： Acupuncture Superovulation Immune tolerance HLA-G/RT-BM1 Embryo implantation