Transcriptional and epigenetic regulation of immune tolerance:roles of the NF-κB family members

作     者：Lei Zhang Xiang Xiao Preston R.Arnold Xian C.Li 

作者机构：Immunobiology and Transplant Science Center and Department of SurgeryHouston Methodist HospitalHoustonTXUSA Department of SurgeryWeill Cornell Medical CollegeCornell UniversityNew YorkNYUSA 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2019年第16卷第4期

页      面：315-323页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 10[医学] 

基　　金：National Institute of Allergy and Infectious Diseases, NIAID, (R01AI129906) National Institute of Allergy and Infectious Diseases, NIAID Center for Scientific Review 

主　　题：Immune tolerance NF-κB chromatin modifiers 

摘      要：Immune tolerance is a highly regulated state and involves diverse mechanisms.Central to the induction of tolerance is the targeted modulation of T-cell activities(both effector and regulatory),in which transcription factors play a significant role.The nuclear factor kappa-B(NF-κB)family is a family of transcription factors that not only are critically involved in diverse T-cell responses but also are regulated by many mechanisms to maintain tolerance and T-cell homeostasis.NF-κB,as a transcription factor,has been extensively studied in recent decades,and the molecular mechanisms that regulate NF-κB activities have been well documented.However,recent studies have revealed exciting new roles for NF-κB;in addition to its transcriptional activity,NF-κB can also activate diverse epigenetic mechanisms that mediate extensive chromatin remodeling of target genes to regulate T-cell activities.In this review article,we highlight recent discoveries and emerging opportunities in targeting NF-κB family members as well as their associated chromatin modifiers in the induction of immune tolerance and in the clinical treatment of immune diseases.