Immune tolerance induced by immune-homeostatic particles
作者机构：Institute of Translational MedicineThe Affiliated Drum Tower Hospital of NanjingUniversity Medical SchoolNanjing210008China Department of DermatologyZhongda HospitalSoutheast UniversityNanjing210009China The Eighth Affiliated Hospital of Sun Yat-sen UniversityShenzhen518033China
出 版 物：《Engineered Regeneration》 (再生工程(英文))
年 卷 期：2021年第2卷第1期
页 面：133-136页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：supported by Jiangsu science and technology project(BK20190353) the Guangdong Basic and Applied Basic Research Foun-dation(Grant Nos.2019A1515111155) the Shenzhen Fundamental Research Program(JCYJ20190808120405672).
主 题：Autoimmune disease Immune tolerance Immune-homeostatic particle Regulatory T cell Immunomodulator
摘 要：Autoimmune diseases,induced by dysfunction of the adaptive immune system,are the common disease categories worldwide.Recently,regulatory T cells(Tregs)enhancing therapies have been demonstrated to treat autoimmune diseases,which could induce immune tolerance to protect cells and tissues from self-attacking of the immune system.However,their widespread application is limited by complex manufacturing process,long production period and high cost.Herein,we give a perspective of immune-homeostatic particles as immune regulators to induce antigen-specific Tregs for treating autoimmune diseases.Disease-specific autoantigen is loaded into the particle to induce Tregs differentiation after release.In addition,the surface of the particles is decorated by specific ligands that could bind and trigger apoptosis of activated T cells,thereby impressing the overreacted immune system.Furthermore,liver sinusoidal endothelial cells(LSEC)-targeting particles are developed to stimulate CD4^(+)T cells differentiation into Tregs.We believe that the immune-homeostatic particles have great potential in autoimmune diseases treatment and are valuable in various immune-related disease treatments.
维普期刊数据库