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A Bioorthogonal-Activated Fluorescence Turn-On Probe Based on Nitrone-Modified 1,8-Naphthalimide for Live-Cell imaging

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Chinese Journal of Chemistry 2022年第2期40卷 209-214页

作者： Yu Teng Hong Yang Xiang Li Yongcheng Wang Dali Yin Yulin Tian State Key Laboratory of Bioactive Substances and Function of Natural Medicine Beijing Key Laboratory of Active Substances Discovery and Drugability EvaluationInstitute of Materia MedicaPeking Union Medical College and Chinese Academy of Medical Sciences1st Xian Nong Tan StreetBeijing 100050China

A nitrone-modified 1,8-naphthalimide was desig ned as a novel bioorthog on alactivated turn-on probe based on strain-promoted alkyne-nitrone cycloadditio n(SPANC).The bioorthog onal cycloadducts were subseque ntly tran sformed into fluoresce nt rearra nge-ment products by photo-accelerati on,which exhibited sign ificant fluoresce nee enhan ceme nt,large stokes shift,and high fluores-cence qua ntum yield.DFT calculati ons were performed to elucidate the fluoresce nee OFF-ON mecha nism.This fluoroge nic strategy was successfully applied to labeling of proteins and visualizing mitochondria in live cells in real time.

关键词： Bioorthogonal reaction Fluorescence Naphthalimide imaging agents Cycloaddition

From Fluorescent Probes to the Theranostics Platform

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Chinese Journal of Chemistry 2022年第16期40卷 1964-1974页

作者： Peng Wei Qing Wang Tao Yi State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620 China Department of Chemistry Fudan UniversityShanghai200438 China

Since the advent of fluorescent probes,they have been widely used in the field of life sciences.Fluorescent probes can not only light up the cells,tissues and organs,but also be used to explore the bio-distribution of specific types of disease markers.Therefore,the development of new fluorescent probes capable of recognition of bio-markers is extremely important for the diagnosis of the related diseases.Herein,we focus on our recent works experienced the evolution from the beginning of simply fluorescent probes to the construction of theranostics platform.We have developed a series of new fluorescent probes for the detecting and imaging of reactive oxygen species(ROS)and specific enzymes in vitro and in living cells.With the shift of the fluorescence signal from visible to near-infrared region,we expanded the application of the fluorescent probes from in vitro to in vivo.Very recently,we further constructed theranostics platforms to combine the diagnosis immediately with the corresponding treatment.

关键词： Fluorescent probes imaging agents Prodrugs Theranostics platform Nanoparticles

Milk exosomes:Nature’s abundant nanoplatform for theranostic applications

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Bioactive Materials 2021年第8期6卷 2479-2490页

作者： Benilde Adriano Nycol M.Cotto Neeraj Chauhan Meena Jaggi Subhash C.Chauhan Murali M.Yallapu Department of Immunology and Microbiology School of MedicineThe University of Texas Rio Grande ValleyMcAllenTX78504USA South Texas Center of Excellence in Cancer Research School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles.Exosomes have proven to be excellent nanocarriers for carrying lipids,proteins,mRNAs,non-coding RNAs,and DNAs,and disseminating long-distance intercellular communications in various biological processes.Among various cell-line or biological fluid derived exosomes,milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications.To be an effective delivery carrier for their clinical translation,exosomes must inbuilt loading,release,targeting,and imaging/tracking characteristics.Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications.This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches.It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents.This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.

关键词： Milk exosomes Extracellular vesicles Drug delivery imaging agents Theranostic applications

A Reaction-based Two-photon Fluorescent imaging Probe for Mitochondrial Superoxide Anion in Vivo

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A Reaction-based Two-photon Fluorescent Imaging Probe for Mi...

Artificial Metalloenzymes for Biocatalysis,Biosensing and imaging

第八届全国化学生物学学术会议

作者： Ping Li Wen Zhang Xiao Liu Haibin Xiao Fan Yang Shan Zhang Xiufen Hu Lu Liu Wei Liu Wei Zhang Bo Tang College of Chemistry Chemical Engineering and Materials ScienceEngineering Research Center of Pesticide and Medicine Intermediate Clean ProductionMinistry of EducationKey Laboratory of Molecular and Nano ProbesMinistry of EducationShandong Normal University

Mitochondrial O

关键词： fluorescent probes imaging agents mitochondria superoxide anion two-photon

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Artificial Metalloenzymes for Biocatalysis,Biosensing and Im...