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hyperbaric oxygen therapy as a complementary treatment for radiation proctitis:Useless or useful?-A literature review

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World Journal of Gastroenterology 2021年第27期27卷 4413-4428页

作者： Diogo Alpuim Costa Carla Espiney Amaro Ana Nunes Joana Santos Cardoso Pedro Modas Daniel Isabel Rosa João Vieira Branco Department of Haematology and Oncology CUF OncologiaLisboa 1998-018Portugal Centro de Medicina Subaquática e Hiperbárica(CMSH) Portuguese NavyLisboa 1649-020Portugal Centro de Investigação Naval(CINAV) Portuguese NavyBase Naval do AlfeiteAlmada 2810-001Portugal OVA Medical School Faculdade de Ciências MédicasLisboa 1169-056Portugal Department of Otorhinolaryngology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Gastroenterology Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of Vascular Surgery Centro Hospitalar Universitário de Lisboa CentralHospital de Santa MartaLisboa 1169-024Portugal Department of Intensive Care Unit Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal Department of General Surgery Hospital das Forças Armadas(HFAR)Lisboa 1649-020Portugal

Radiotherapy(RT)is the backbone of multimodality treatment of more than half of cancer *** new modern RT techniques,late complications may occur such as radiation proctitis(RP).The natural history of RP is *** symptoms may resolve spontaneously or require conservative *** the other hand,for similar and uncomplicated clinical contexts,symptoms may persist and can even be refractory to the progressive increase in treatment *** the last decades,an enormous therapeutic armamentarium has been considered in RP,including hyperbaric oxygen therapy(HBOT).Currently,the evidence regarding the impact of HBOT on RP and its benefits is *** prospective and randomised studies are necessary to validate HBOT’s effectiveness in the‘real world’clinical *** article reviewed the relevant literature on pathophysiology,clinical presentation,different classifications and discuss RP management including a proposal for a therapeutic algorithm with a focus on HBOT.

关键词： Radiation proctitis Radiation proctopathy Radiotherapy Radio-induced lesion Late radiation tissue injury Delayed radiation injury Late sequelae hyperbaric oxygen therapy hyperbaric oxygen Review

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hyperbaric oxygen protects against PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of cell apoptosis and autophagy

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BIOCELL 2022年第1期46卷 137-148页

作者： JIANRONG YANG WAN CHEN XING ZHOU YAOXUAN LI ZHIHUANG NONG LIYUAN ZHOU XUAN WEI XIAORONG PAN CHUNXIA CHEN WENSHENG LU Hepatobiliary Surgery Guangxi Academy of Medical SciencesThe People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530021China Department of Emergency The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530021China Department of Endocrinology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530021China Department of Neurology The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530021China Department of Pharmacy The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530021China Department of hyperbaric oxygen The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530021China Department of Research Center of Medical Sciences The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning530021China

In this study,we investigated the protective effect of hyperbaric oxygen(HBO)on PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion and its possible ***12 and H9C2 cell oxygen-glucose deprivation/reperfusion model were *** were divided into a control group,model group,hyperbaric air(HBA)group and HBO *** cell viability was detected by the CCK8 *** 33342 and PI staining assays and mitochondrial membrane potential(MMP)assays were used to detect cell *** ultrastructure of cells,including autophagosomes,lysosomes,and apoptosis,were examined using a transmission electron *** expression of autophagy-related proteins was detected by cellular immunofluorescence and *** results showed that HBO can significantly improve the vitality of damaged PC12 and H9C2 cells caused by oxygen–glucose deprivation/*** can significantly inhibit apoptosis of PC12 and H9C2 cells caused by oxygenglucose deprivation/***,we found that the protective mechanism of PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion may be related to the inhibition of the autophagy *** this study,the results of cellular immunofluorescence and immunocytochemistry experiments showed that the 4E-BP1,p-AKt and mTOR levels of PC12 and H9C2 cells in the model group decreased,while the levels of LC3B,Atg5 and p53 ***,after HBO treatment,these autophagy-related indexes were *** addition,observation of the cell ultrastructure with transmission electron microscopy found that in the model group,a significant increase in the number of autophagic vesicles was *** the HBO group,a decrease in autophagic vesicles was *** study demonstrated that hyperbaric oxygen protects against PC12 and H9C2 cell damage caused by oxygen-glucose deprivation/reperfusion via the inhibition of cell apoptosis and autophagy.

关键词： hyperbaric oxygen PC12 cells H9C2 cells Celoxygen-glucose deprivation/reperfusion Apoptosis Autophagy

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The mechanism by which hyperbaric oxygen treatment alleviates spinal cord injury: genome-wide transcriptome analysis

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Neural Regeneration Research 2022年第12期17卷 2737-2742页

作者： Zhen-Cheng Sun Fang Liang Jing Yang Yong Hai Qing-Jun Su Xue-Hua Liu Department of Orthopedic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Department of hyperbaric oxygen Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina

Accumulating studies have demonstrated that hyperbaric oxygen(HBO)treatment alleviates spinal cord injury(SCI).However,the underlying mechanism by which HBO alleviates SCI remains to be *** this study,we performed genome-wide transcriptional profiling of the spinal cord between SCI mice and mice that received HBO treatment by high-throughput RNA sequencing at 1 week after *** also compared genome-wide transcriptional profiles from SCI mice and sham-operated *** found 76 differentially co-expressed genes in sham-operated mice,SCI mice,and HBO-treated SCI *** Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis,we identified the biological characteristics of these differentially expressed genes from the perspectives of cell component,biological process,and molecular *** also found enriched functional pathways including ferroptosis,calcium signaling pathway,serotonergic synapse,hypoxia-inducible factor-1 signaling pathway,cholinergic synapse,and neuroactive ligand-receptor *** performed quantitative reverse transcription-polymerase chain reaction and validated that HBO treatment decreased the expression of Hspb1(heat shock protein beta 1),Hmox1(heme oxygenase 1),Ftl1(ferritin light polypeptide 1),Tnc(tenascin C)and Igfbp3(insulin-like growth factor binding protein 3)and increased the expression of Slc5a7(solute carrier family 5 choline transporter member 7)after *** results revealed the genome-wide transcriptional profile of the injured spinal cord after HBO *** findings contribute to a better understanding of the mechanism by which HBO treats SCI and may provide new targets for SCI intervention.

关键词： Ftl1 genome-wide transcriptome Hmox1 Hspb1 hyperbaric oxygen Igfbp3 Slc5a7 spinal cord injury Tnc

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hyperbaric oxygen and Ginkgo Biloba Extract Ameliorate Cognitive and Memory Impairment via Nuclear Factor Kappa-B Pathway in Rat Model of Alzheimer＇s Disease

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Chinese Medical Journal 2015年第22期128卷 3088-3093页

作者： Li-Da Zhang Li Ma Li Zhang Jian-Guo Dai Li-Gong Chang Pei-Lin Huang Xiao-Qiang Tian Department of hyperbaric oxygen Affiliated ZhongDa Hospital of Southeast University Nanjing Jiangsu 210009 China Department of Neurology Brain Hospital Affiliated of Nanjing Medical University Nanjing Jiangsu 210029 China Department of Pathology Nanjing University of Traditional Chinese Medicine Nanjing Jiangsu 210023 China Department of Pathology Medicine School of Southeast University Nanjing Jiangsu 210009 China Medical Oncology The Second Hospital of Nanjing Affiliated to Medical School of Southeast University Nanjing Jiangsu 210003 China

Background： hyperbaric oxygen （HBO） and Ginkgo biloba extract （e.g., EGB 761） were shown to ameliorate cognitive and memory impairment in Alzheimcr＇s disease （AD）. However, the exact mechanism remains elusive. The aim of the present study was to investigate the possible mechanisms of HBO and EGB 761 via the function of nuclear factor kappa-B （NF-κB） pathway. Methods： AD rats were induced by injecting β-amyloid 25-35 into the hippocampus. All animals were divided into six groups： Normal. sham. AD model, HBO （2 atmosphere absolute： 60 min/d）, EGB 761 （20 mg·kg^-1 ·d ^-1）, and HBO/EGB 761 groups. Morris water maze tests were used to assess cognitive, and memory capacities of rats： TdT-mediated dUTP Nick-End Labeling staining and Western blotting were used to analyze apoptosis and NF-κB pathway-related proteins in hippocampus tissues. Results： Morris water maze tests revealed that EGB 761 and HBO significantly improved the cognitive and memory ability of AD rats. In addition, the protective effect of combinational therapy （HBO/EGB 761 ） was superior to either HBO or EGB 761 alone. In line. redticed apoptosis with NF-κB pathway activation was observed in hippocampus neurons treated by HBO and EGB 761. Conclusions： Our results suggested that HBO and EGB 761 improve cognitive and memory capacity in a rat model of AD. The protective effects are associated with the reduced apoptosis with NF-κB pathway activation in hippocampus neurons.

关键词： Ginkgo Biloba Extract 761 hyperbaric oxygen Nuclear Factor Kappa-B Rats Alzheimer's Disease

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Key Genes Involved in the Beneficial Mechanism of hyperbaric oxygen for Glioblastoma and Predictive Indicators of hyperbaric oxygen Prolonging Survival in Glioblastoma Patients

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Current Medical Science 2024年第5期44卷 1036-1046页

作者： Zi-qi REN Ren-dong WANG Cong WANG Xiao-hui REN Dong-guo LI Ya-ling LIU Qiu-hong YU Department of hyperbaric oxygen Beijing Tiantan HospitalCapital Medical UniversityBeijing100070China School of Biomedical Engineering Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical ApplicationCapital Medical UniversityBeijing100069China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing100070China

Objective The prognosis of glioblastoma is poor,and therapy-resistance is largely attributed to intratumor *** oxygen(HBO)effectively alleviates ***,the sole role of HBO in glioblastoma remains *** previously reported that HBO can promote apoptosis,shorten protrusions,and delay growth of glioblastoma,but the molecular mechanism is *** aimed to test candidate genes in HBO-exposed glioblastoma cells and to analyze their correlation with the survival of glioblastoma *** Glioblastoma cell lines exposed to repetitive HBO or normobaric air(NBA)were collected for RNA isolation and microarray data *** analysis,KEGG pathway analysis and survival analysis of the differentially expressed genes(DEGs)were *** HBO not only inhibited hypoxia-inducing genes including CA9,FGF11,PPFIA4,TCAF2 and SLC2A12,but also regulated vascularization by downregulating the expression of COL1A1,COL8A1,COL12A1,RHOJ and FILIP1L,ultimately attenuated hypoxic microenvironment of *** attenuated inflammatory microenvironment by reducing the expression of NLRP2,CARD8,MYD88 and *** prevented metastasis by downregulating the expression of NTM,CXCL12,CXCL13,CXCR4,CXCR5,CDC42,IGFBP3,IGFBP5,GPC6,MMP19,ADAMTS1,EFEMP1,PTBP3,NF1 and *** upregulated the expression of BAK1,PPIF,DDIT3,TP53I11 and FAS,whereas downregulated the expression of MDM4 and SIVA1,thus promoting *** upregulated the expression of CDC25A,MCM2,PCNA,RFC33,DSCC1 and CDC14A,whereas downregulated the expression of ASNS,CDK6,CDKN1B,PTBP3 and MAD2L1,thus inhibiting cell cycle *** these DEGs,17 indicator-genes of HBO prolonging survival were *** HBO is beneficial for *** patients with these predictive indicators may prolong survival with HBO *** potential therapeutic targets especially COL1A1,ADAMTS1 and PTBP3 deserve further validation.

关键词： glioblastoma hyperbaric oxygen differentially expressed gene gene enrichment analysis survival analysis

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hyperbaric oxygen treatment promotes neural stem cell proliferation in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage

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Neural Regeneration Research 2013年第13期8卷 1220-1227页

作者： Zhichun Feng Jing Liu Rong Ju Department of Neonatology & Neonatal Intensive Care Unit Bayi Children's Hospital Affiliated to General Hospital of Beijing Military Command Department of Neonatology Chengdu Women's & Children's Central Hospital

hyperbaric oxygen therapy for the treatment of neonatal hypoxic-ischemic brain damage has been used clinically for many years, but its effectiveness remains controversial. In addition, the mechanism of this potential neuroprotective effect remains unclear. This study aimed to investigate the influence of hyperbaric oxygen on the proliferation of neural stem cells in the subventricular zone of neonatal Sprague-Dawley rats （7 days old） subjected to hypoxic-ischemic brain damage. Six hours after modeling, rats were treated with hyperbaric oxygen once daily for 7 days. Immunohistochemistry revealed that the number of 5-bromo-2＇-deoxyuridine positive and nestin positive cells in the subventricular zone of neonatal rats increased at day 3 after hypoxic-ischemic brain damage and peaked at day 5. After hyperbaric oxygen treatment, the number of 5-bromo-2＇- deoxyuddine positive and nestin positive cells began to increase at day 1, and was significantly higher than that in normal rats and model rats until day 21. Hematoxylin-eosin staining showed that hyperbaric oxygen treatment could attenuate pathological changes to brain tissue in neonatal rats, and reduce the number of degenerating and necrotic nerve cells. Our experimental findings indicate that hyperbaric oxygen treatment enhances the proliferation of neural stem cells in the subventricular zone of neonatal rats with hypoxic-ischemic brain damage, and has therapeutic potential for promoting neurological recovery following brain injury.

关键词： neural regeneration brain injury neonatal hypoxic-ischemic encephalopathy hypoxic-ischemicbrain damage hyperbaric oxygen neural stem cells neurons proliferation subventricular zone neonatal rats nestin grants-supported paper neuroregeneration

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hyperbaric oxygen therapy improves cognitive functioning after brain injury

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Neural Regeneration Research 2013年第35期8卷 3334-3343页

作者： Su Liu Guangyu Shen Shukun Deng Xiubin Wang Qinfeng Wu Aisong Guo Department of Rehabilitation Medicine Affiliated Hospital of Nantong University Department of Imaging Affiliated Hospital of Nantong University

hyperbaric oxygen therapy has been widely applied and recognized in the treatment of brain injury; however, the correlation between the protective effect of hyperbaric oxygen therapy and changes of metabolites in the brain remains unclear. To investigate the effect and potential mechanism of hy- perbaric oxygen therapy on cognitive functioning in rats, we established traumatic brain injury models using Feeney＇s free falling method. We treated rat models with hyperbaric oxygen therapy at 0.2 MPa for 60 minutes per day. The Morris water maze test for spatial navigation showed that the average escape latency was significantly prolonged and cognitive function decreased in rats with brain injury. After treatment with hyperbaric oxygen therapy for 1 and 2 weeks, the rats＇ spatial learning and memory abilities were improved. Hydrogen proton magnetic resonance spectroscopy analysis showed that the N-acetylaspartate/creatine ratio in the hippocampal CA3 region was sig- nificantly increased at 1 week, and the N-acetylaspartate/choline ratio was significantly increased at 2 weeks after hyperbaric oxygen therapy. Nissl staining and immunohistochemical staining showed that the number of nerve cells and Nissl bodies in the hippocampal CA3 region was significantly increased, and glial fibrillary acidic protein positive cells were decreased after a 2-week hyperbaric oxygen therapy treatment. Our findings indicate that hyperbaric oxygen therapy significantly im- proves cognitive functioning in rats with traumatic brain injury, and the potential mechanism is me- diated by metabolic changes and nerve cell restoration in the hippocampal CA3 region.

关键词： neural regeneration brain injury hyperbaric oxygen magnetic resonance spectroscopy astrocytes immunohistochemistry choline creatine N-acetylaspartate CA3 region Morris water maze hippocampus neuroregeneration

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hyperbaric oxygen intervention on expression of hypoxia-inducible factor-1 α and vascular endothelial growth factor in spinal cord injury models in rats

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Chinese Medical Journal 2013年第20期126卷 3897-3903页

作者： Yi Zhou Xue-hua Liu Shao-dong Qu Jing Yang Zhi-wei Wang Chun-jin Gao Qing-jun Su Department of Orthopedics Shenzhou Hospital Shenyang Medical College Shenyang Liaoning 110002 China.

Background hyperbaric oxygen （HBO） intervention is a main therapeutic method and the curative effect has been certified for spinal cord injury （SCI）, but the mechanisms of the neuroprotective effect of HBO on SCI remain elusive. This study aimed to observe the change in expression of hypoxia-inducible factor-1α （HIF-1α） and vascular endothelial growth factor （VEGF） after SCI at different time points and to investigate the neuroprotective mechanism of HBO on SCI in rats.

关键词： hyperbaric oxygen spinal cord injury hypoxia-inducible factor-1α vascular endothelial growth factor

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hyperbaric oxygen therapy improves local microenvironment after spinal cord injury

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Neural Regeneration Research 2014年第24期9卷 2182-2188页

作者： Yang Wang Shuquan Zhang Min Luo Yajun Li Department of Orthopedics China-Japan Union Hospital Jilin University Department of Orthopedics Nankai Hospital School of Mathematics Jilin University

Clinical studies have shown that hyperbaric oxygen therapy improves motor function in patients with spinal cord injury. In the present study, we explored the mechanisms associated with the recovery of neurological function after hyperbaric oxygen therapy in a rat model of spinal cord injury. We established an acute spinal cord injury model using a modification of the free-falling object method, and treated the animals with oxygen at 0.2 MPa for 45 minutes, 4 hours after injury. The treatment was administered four times per day, for 3 days. Compared with model rats that did not receive the treatment, rats exposed to hyperbaric oxygen had fewer apoptotic cells in spinal cord tissue, lower expression levels of aquaporin 4/9 mRNA and protein, and more NF-200 positive nerve fibers. Furthermore, they had smaller spinal cord cavities, rapid recovery of somatosensory and motor evoked potentials, and notably better recovery of hindlimb motor function than model rats. Our findings indicate that hyperbaric oxygen therapy reduces apoptosis, downregulates aquaporin 4/9 mRNA and protein expression in injured spinal cord tissue, improves the local microenvironment for nerve regeneration, and protects and repairs the spinal cord after injury.

关键词： nerve regeneration spinal cord injury hyperbaric oxygen motor function rats microenvironment aquaporin 4 aquaporin 9 neural regeneration

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hyperbaric oxygen treatment induces dynamic ATPase activity changes in the rat brain following transient global cerebral ischemia-reperfusion

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Neural Regeneration Research 2008年第9期3卷 1018-1021页

作者： Shiming Xu Hongjuan Wang Tongnan Gu Xiuyan Zhou Rui Chen Department of Biochemistry Yanjing Medical College Capital Medical University Beijing 101300 China Department of Biochemistry and Molecular Biology Capital Medical University Beijing 100069 China

BACKGROUND： Energy depletion, induced by ischemia or hypoxia, is one of the first events in neuronal injury. OBJECTIVE： To investigate the dynamic changes of Na^＋-K^＋-ATPase and Ca^2＋-ATPase activity in the rat brain following transient global cerebral ischemia-reperfusion （IR）, as well as the effects of hyperbaric oxygen （HBO） treatment. DESIGN, TIME AND SETTING： A randomized and controlled animal study was performed in the Department of Biochemistry and Molecular Biology, Capital Medical University between February and December 2006. MATERIALS： Clean-grade, female, Sprague Dawley rats were provided by the Animal Research Department of Capital Medical University （License number： SYXK11-00-0047）. Na^＋-K^＋-ATPase and Ca^2＋-ATPase kits were provided by Nanjing Jiancheng Bioengineering Institute （Nanjing, China）. A hyperbaric oxygen chamber （DWC150-300） was supplied by Shanghai 701 Medical oxygen Chamber Factory （Shanghai, China）. METHODS： Sixty-three rats were randomly divided into nine groups： sham operated group （sham-O） as control, groups of IR, and groups treated with hyperbaric oxygen （HBO） after IR. Animal from the IR and HBO groups were sacrificed after four different survival intervals of 6, 24, 48 and 96 hours, respectively. Each group consisted of seven rats. The rats of HBO groups were placed into the hyperbaric chamber. The HBO chamber was flushed with pure oxygen for 5 minutes, followed by a gradual rise in pressure over 5 minutes and stabilization at 0.2 MPa. Then, pure oxygen was supplied for 45 minutes in stabilized pressure, followed by gradually reduced pressure over 15 minutes. The rats of the 6-h HBO group were placed into the HBO chamber following reperfusion for 3 hours on the first day, which was repeated on three consecutive days, always at the same time. Rats in the sham-O group and IR group remained under normal atmospheric pressure. MAIN OUTCOME MEASURES： The Na^＋-K^＋-ATPase and Ca^2＋-ATPase activity in rat brain homogenate was detected by t

关键词： ATPase cerebral ischemia-reperfusion hyperbaric oxygen Sprague Dawley rats

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