Hyperbaric oxygen intervention on expression of hypoxia-inducible factor-1 α and vascular endothelial growth factor in spinal cord injury models in rats

作     者：Yi Zhou Xue-hua Liu Shao-dong Qu Jing Yang Zhi-wei Wang Chun-jin Gao Qing-jun Su 

作者机构：Department of Orthopedics Shenzhou Hospital Shenyang Medical College Shenyang Liaoning 110002 China. 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2013年第126卷第20期

页      面：3897-3903页

核心收录：

学科分类：10[医学] 

基　　金：This study was supported by a grant of Beijing Natural Science Foundation (No.7102062) 

主　　题：hyperbaric oxygen spinal cord injury hypoxia-inducible factor-1α vascular endothelial growth factor 

摘      要：Background Hyperbaric oxygen （HBO） intervention is a main therapeutic method and the curative effect has been certified for spinal cord injury （SCI）, but the mechanisms of the neuroprotective effect of HBO on SCI remain elusive. This study aimed to observe the change in expression of hypoxia-inducible factor-1α （HIF-1α） and vascular endothelial growth factor （VEGF） after SCI at different time points and to investigate the neuroprotective mechanism of HBO on SCI in rats.