检索结果-南通市图书馆

Identification of 3-ketocapnine reductase activity within the human microbiota

mLife 2024年第2期3卷 307-316页

作者： Xiaotong Wu Lukuan Hou Haili Zhang Yi Ma Jufang Wang Mingwei Cai Xiaoyu Tang School of Biology and Biological Engineering South China University of TechnologyGuangzhouChina Institute of Chemical Biology Shenzhen Bay LaboratoryShenzhenChina College of Chemistry and Pharmacy Northwest A&F UniversityYanglingChina

The microbial synthesis of sulfonolipids within the human body is likely involved in maintaining human health or causing ***,the enzymes responsible for their biosynthesis remain largely *** this study,we identified and verified the role of 3-ketocapnine reductase,the third-step enzyme,in the four-step conversion of L-phosphoserine into sulfobacin B both in vivo and in *** finding builds upon our previous research into sulfonolipid biosynthesis,which focused on the vaginal bacterium Chryseobacterium gleum DSM 16776 and the gut bacterium Alistipes finegoldii DSM *** comprehensive gene mapping,we demonstrate the widespread presence of potential sulfonolipid biosynthetic genes across diverse bacterial species inhabiting various regions of the human *** findings shed light on the prevalence of sulfonolipid-like metabolites within the human microbiota,suggesting a potential role for these lipid molecules in influencing the intricate biointeractions within the complex microbial ecosystem of the human body.

关键词： 3-ketocapnine reductase capnines human microbiota sulfonolipids

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regulatory functions and mechanisms of human microbiota in infectious diseases

引用

hLife 2024年第10期2卷 496-513页

作者： Yingxu Fang Zehui Lei Lingqiang Zhang Cui Hua Liu Qiyao Chai CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijingChina Savaid Medical School University of Chinese Academy of SciencesBeijingChina State Key Laboratory of Medical Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijingChina

The human microbiota,a diverse community of microorganisms living on or within their hosts,play an irreplaceable role in maintaining human *** of the microbiota is associated with the pathogenesis of diverse human *** recent years,growing evidence has been presented to support the substantial effect of human microbiota on the progression of infectious *** this review,we describe the functional role of human microbiota in infec-tious diseases by highlighting their Janus-faced effects in the regulation of acute and chronic infections as well as their related ***,we review the latest advances elucidating the mechanisms underlying tri-directional interactions between the microbiota,hosts,and invading pathogens,with a further discussion on external environ-mental factors that shape this interconnected regulatory network.A better understanding of the regulatory functions and mechanisms of human microbiota in infectious diseases will facilitate the development of new diagnostic,preven-tive,and therapeutic approaches for infectious diseases.

关键词： human microbiota infectious diseases co-morbidities microbiota-host-pathogen interactions environ-mental factors

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

microbiota revolution:How gut microbes regulate our lives

引用

World Journal of Gastroenterology 2023年第28期29卷 4368-4383页

作者： Marica Colella Ioannis Alexandros Charitos Andrea Ballini Concetta Cafiero Skender Topi Raffaele Palmirotta Luigi Santacroce Interdisciplinary Department of Medicine Section of Microbiology and VirologyUniversity of Bari“Aldo Moro”Bari 70124Italy Maugeri Clinical Scientific Research Institutes(IRCCS)of Pavia-Division of Pneumology and Respiratory Rehabilitation Scientific Institute of BariBari 70124Italy Department of Clinical and Experimental Medicine University of FoggiaFoggia 71122Italy Department of Precision Medicine University of Campania“Luigi Vanvitelli”Naples 80138Italy Area of Molecular Pathology Anatomic Pathology UnitFabrizio Spaziani HospitalFrosinone 03100Italy Department of Clinical Disciplines School of Technical Medical SciencesUniversity of Elbasan“A.Xhuvani”Elbasan 3001Albania

The human intestine is a natural environment ecosystem of a complex of diversified and dynamic microorganisms,determined through a process of competition and natural selection during *** intestinal microorganisms called microbiota and are involved in a variety of mechanisms of the organism,they interact with the host and therefore are in contact with the organs of the various ***,they play a crucial role in maintaining host homeostasis,also influencing its ***,microorganisms perform a series of biological functions important for human *** host provides the microorganisms with the environment and nutrients,simultaneously drawing many benefits such as their contribution to metabolic,trophic,immunological,and other *** these reasons it has been reported that its quantitative and qualitative composition can play a protective or harmful role on the host ***,a dysbiosis can lead to an association of unfavourable factors which lead to a dysregulation of the physiological processes of ***,it has previously noted that the gut microbiota can participate in the pathogenesis of autoimmune diseases,chronic intestinal inflammation,diabetes mellitus,obesity and atherosclerosis,neurological disorders(e.g.,neurological diseases,autism,etc.)colorectal cancer,and more.

关键词： Microbiology human microbiota Intestinal microbiota Immune system Metabolites Dysbiosis Probiotics Diseases Cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Prospective study of probiotic supplementation results in immune stimulation and improvement of upper respiratory infection rate

引用

Synthetic and Systems Biotechnology 2018年第2期3卷 113-120页

作者： Hong Zhang Chiajung Yeh Zonglian Jin Liwei Ding Bryan Y.Liu Li Zhang H.Kathleen Dannelly Beijing Chao-Yang Hospital affiliated to Capital Medical University 8 Gongti South RoadChaoyang DistrictBeijing10020China Hangzhou Weiquan Foods Co. LTD R&D Center1688 Wu Zhong RoadMinhang DistrictShanghai201100China College of Applied Arts and Science of Beijing Union University 197 Bei Tu Cheng West RoadHaitian DistrictBeijing100108China SPRIM China 100 Zunyi RoadChangning DistrictShanghai200336China Indiana State University Department of Biology600 Chestnut StreetTerre HauteIN 47809USA

The human gut microbiota is an important environmental factor for human health with evolutionarily conserved roles in immunity,metabolism,development,and behavior of the *** organisms are claimed to offer several functional properties including stimulation of immune *** purpose of this study is to investigate the effects of a probiotic supplementation on adult volunteers who have contracted the common cold four or more times in the past *** study is a single center,doubleblind,randomized,controlled,prospective *** received a probiotic drink containing Lactobacillus paracasei(at least 3×10^7 colony forming units(CFU)ml^-1),Lactobacillus casei 431®(at least 3×10^7 CFU ml1)and Lactobacillus fermentium PCC®(at least 3×10^6 CFU ml^-1)or an identical placebo without probiotics for a 12-week study *** consumption of probiotics significantly reduced the incidence of upper respiratory infection(p<0.023)and flu-like symptoms with an oral temperature higher than 38℃(p<0.034)as compared to the placebo *** that consumed probiotics demonstrated a significantly higher level of IFN-g in the serum(p<0.001)and sIgA in the gut(p<0.010)as compared to the placebo group and a significant higher level of serum IFN-g(p<0.001)and gut sIgA(p<0.001)as compared to their baseline test *** contrast,there were no significant differences in the serum IL-4,IL-10,IgA,IgG or IgM between the probiotics and the placebo *** of this study demonstrated that probiotics were safe and effective for fighting the common cold and influenza-like respiratory infections by boosting the immune system.

关键词： Probiotics Upper respiratory infections human microbiota IFN-g sIgA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：