Regulatory functions and mechanisms of human microbiota in infectious diseases

作     者：Yingxu Fang Zehui Lei Lingqiang Zhang Cui Hua Liu Qiyao Chai 

作者机构：CAS Key Laboratory of Pathogen Microbiology and ImmunologyInstitute of MicrobiologyChinese Academy of SciencesBeijingChina Savaid Medical SchoolUniversity of Chinese Academy of SciencesBeijingChina State Key Laboratory of Medical ProteomicsBeijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijingChina 

出 版 物：《hLife》 (健康科学（英文）)

年 卷 期：2024年第2卷第10期

页      面：496-513页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(2022YFC2302900 to C.H.L.,2021YFA1300200 to C.H.L.and L.Z.,and 2022YFC2303201 to Q.C.) the National Natural Science Foundation of China(82330069,81825014,and 31830003 to C.H.L.and 82171744 to Q.C.) the State Key Laboratory of Proteomics(SKLP-K202001 to C.H.L.and L.Z.) 

主　　题：human microbiota infectious diseases co-morbidities microbiota-host-pathogen interactions environ-mental factors 

摘      要：The human microbiota,a diverse community of microorganisms living on or within their hosts,play an irreplaceable role in maintaining human *** of the microbiota is associated with the pathogenesis of diverse human *** recent years,growing evidence has been presented to support the substantial effect of human microbiota on the progression of infectious *** this review,we describe the functional role of human microbiota in infec-tious diseases by highlighting their Janus-faced effects in the regulation of acute and chronic infections as well as their related ***,we review the latest advances elucidating the mechanisms underlying tri-directional interactions between the microbiota,hosts,and invading pathogens,with a further discussion on external environ-mental factors that shape this interconnected regulatory network.A better understanding of the regulatory functions and mechanisms of human microbiota in infectious diseases will facilitate the development of new diagnostic,preven-tive,and therapeutic approaches for infectious diseases.