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Photon penetration depth in human brain for light stimulation and treatment:A realistic Monte Carlo simulation study

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Journal of Innovative Optical Health Sciences 2017年第5期10卷 59-68页

作者： Ting Li Chang Xue Pengbo Wang Yan Li Lanhui Wu Institute of Biomedical Engineering Chinese Academy of Medical Science and Peking Union Medical College 300192 TianjinP.R.China State Key Lab Elect Thin Film&Integrated Device and Department of Biomedical Engineering University of Electronic Science&Technology of China Chengdu 610054 P.R.China Design Center Avic Beijing Keeven Aviation Instrument Co. Ltd China Aviation Industry Corporation Beijing 100098P.R.China

Light has been clinically utilized as a stimulation in medical treatment,such as Low-level laser therapy and photodynamic thenapy,which has been more and more widely accepted in *** penetration depth of the treatment light is important for precision treatment and safety *** isue of light penetration has been highlighted in biomedical optics field for ***,quantitative research is sparse and even there are conflicts of view on the capability of near-infrared light penet ration into brain *** study attempts to quantitatively revisit this issue by innovative high-realistic 3D Monte Caro modeling of stimulated light penetnation within high precision Visible Chinese human *** properties of light,such as its wave-length,ilumination profle and size are concern in this *** made stra ightforward and quantitative comparisons among the ffects by the light properties(i.e.,wavelengths:660,810 and 980 nn;beam types:Gaussi an and flat beamn;bear dianeters:0,2,4 and 6 cm)which are in the range of light *** findings include about 3%of light dosage within brain tisue;the combination of Gaussian beam and 810nm light make the max imum light penetration(>5cm),which allows light to cross through gray matter into white *** study offered us,the first time as we know,quantitative guide for light stimulation parameter optimization in medical treatment.

关键词： Penetration depth light therapy light propagation MCVM human brain

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Combined spatial frequency spectroscopy analysis with visible resonance Raman for optical biopsy of human brain metastases of lung cancers

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Journal of Innovative Optical Health Sciences 2019年第2期12卷 93-104页

作者： Yan Zhou Cheng-Hui Liu Yang Pu Binlin Wu Thien An Nguyen Gangge Cheng Lixin Zhou Ke Zhu Jun Chen Qingbo Li Robert R.Alfano The Air Force Medical Center PLANo.30 FuchengluHaidian DistrictBeijing 100142P.R.China Department of Physics The City College of the City University of New York Institute of Ultrafast Spectroscopy and Lasers NY 10031USA Physics Department and CSCU Center for Nanotechnology Southern Connecticut State University 501 Crescent Street New HavenCT 06515USA Beijing Cancer Hospital No.52Fuchenglu Haidian DistrictBeijing 100142P.R.China Institute of Physics Chinese Academy of Sciences(CAS)Beijing 100190P.R.China Department of Cardiology Tianjin Medical University General Hospital Tianjin 300052P.R.China Beihang University Xueyuan Road No.37Haidian DistrictBeijing 100191P.R.China

The purpose of this study is to examine optical spatial frequency spectroscopy analysis(SFSA)combined with visible resonance Raman(VRR)spectroscopic method,for thefirst time,to discriminate human brain metastases of lung cancers adenocarcinoma(ADC)and squamous cell carcinoma(SCC)from normal tissues.A total of 31 label-free micrographic images of three type of brain tissues were obtained using a confocal micro-Raman spectroscopic *** spectra of the corresponding samples were synchronously collected using excitation wavelength of 532 nm from the same sites of the *** SFSA method,the difference in the randomness of spatial frequency structures in the micrograph images was analyzed using Gaussian *** standard deviations,calculated from the spatial frequencies of the micrograph images were then analyzed using support vector machine(SVM)*** key VRR biomolecularfingerprints of carotenoids,tryptophan,amide II,lipids and proteins(methylene/methyl groups)were also analyzed using SVM *** three types of brain tissues were identified with high accuracy in the two approaches with high *** results show that SFSA–VRR can potentially be a dual-modal method to provide new criteria for identifying the three types of human brain tissues,which are on-site,real-time and label-free and may improve the accuracy of brain biopsy.

关键词： Spatial frequency spectroscopy analysis(SFSA) visible resonance Raman(VRR) human brain metastatic lung cancer photomicrograph image support vector machine(SVM)

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Bioinspired nanofluidic iontronics for brain-like computing

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Nano Research 2024年第2期17卷 503-514页

作者： Lejian Yu Xipeng Li Chunyi Luo Zhenkang Lei Yilan Wang Yaqi Hou Miao Wang Xu Hou State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Institute of Artificial Intelligence Xiamen UniversityXiamen 361005China Department of Physics Research Institute for Biomimetics and Soft MatterFujian Provincial Key Laboratory for Soft Functional Materials ResearchJiujiang Research InstituteCollege of Physical Science and TechnologyXiamen UniversityXiamen 361005China The Higher Educational Key Laboratory for Biomedical Engineering of Fujian Province Department of BiomaterialsResearch Center of Biomedical Engineering of XiamenCollege of MaterialsXiamen UniversityXiamen 361005China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China Binzhou Institute of Technology Binzhou 256600China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361102China Engineering Research Center of Electrochemical Technologies of Ministry of Education Xiamen UniversityXiamen 361005China

The human brain performs computations via a highly interconnected network of *** inspiration from the information delivery and processing mechanism of the human brain in central nervous systems,bioinspired nanofluidic iontronics has been proposed and gradually engineered to overcome the limitations of the conventional electron-based von Neumann architecture,which shows the promising potential to enable efficient brain-like *** and tunable nanofluidic ion transport behaviors and spatial confinement show promising controllability of charge carriers,and a wide range of structural and chemical modification paves new ways for realizing brain-like ***,a comprehensive framework of mechanisms and design strategy is summarized to enable the rational design of nanofluidic systems and facilitate the further development of bioinspired nanofluidic *** review provides recent advances and prospects of the bioinspired nanofluidic iontronics,including ion-based brain computing,comprehension of intrinsic mechanisms,design of artificial nanochannels,and the latest artificial neuromorphic functions ***,the challenges and opportunities of bioinspired nanofluidic iontronics in the pioneering and interdisciplinary research fields are proposed,including brain–computer interfaces and artificial neurons.

关键词： human brain ion transport nanofluidics brain-like computing memristive effect

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Identification and characterization of NBEAL1, a novel human neurobeachin-like 1 protein gene from fetal brain, which is up regulated in glioma

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第二军医大学学报 2005年第2期26卷 232-232页

作者： Chen J Lu Y Xu J Huang Y Cheng H Hu G Luo C Lou M Cao G Xie Y Ying K Department of Neurosurgery ChangZheng Hospital Second Military Medical University Shanghai 200003China

The Beige and Chediak-Higashi (BEACH) domain is highly conserved in a large family of eukaryotic proteins, and is crucial for their functions in vesicle trafficking, membrane dynamics and receptor signaling. From a fetal brain cDNA library, we isolated a cDNA of 3858 bp encoding a novel human BEACH protein, which was named as human neurobeachin-like 1 (NBEAL1) gene. The cDNA had an open reading frame (ORF) of 3006 bp encoding a putative 1001 amino acid protein. The NBEAL1 gene was located on human chromosome 2q33-2q34 and consisted of 25 exons spanning about 73 kb of the human genome. PSORT analysis indicated that the NBEAL1 protein contained a vacuolar-targeting motif ILPK, which suggested the protein might be located in the cell lysosome. The expression pattern was examined by reverse transcription/polymerase chain reaction (RT-PCR), which showed that the transcripts were highly expressed in the human brain, kidney, prostate, and testis while lowly in the ovary, small intestine, colon and peripheral blood leukocyte. In addition, the RT-PCR result of and Northern blot showed that the novel gene was highly expressed in the biopsies of different grade glioma, especially in that of lower grade ones, which suggested it might be correlative with the glioma.

关键词： reverse transcription expression pattern peripheral blood Northern blot human genome cDNA library human brain novel gene amino acid

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A review of functional MRI application for brain research of Chinese language processing

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Magnetic Resonance Letters 2023年第1期3卷 1-13,I0002页

作者： Jianqiao Ge Jia-Hong Gao Center for MRI Research Academy for Advanced Interdisciplinary StudiesPeking UniversityBeijing100871China McGovern Institute for brain Research Peking UniversityBeijing100871China Beijing City Key Laboratory for Medical Physics and Engineering Institute of Heavy Ion PhysicsSchool of PhysicsPeking UniversityBeijing100871China National Biomedical Imaging Center Peking UniversityBeijing100871China

As one of the most widely used languages in the world,Chinese language is distinct from most western languages in many properties,thus providing a unique opportunity for understanding the brain basis of human language and *** recent years,non-invasive neuroimaging techniques such as magnetic resonance imaging(MRI)blaze a new trail to comprehensively study specific neural correlates of Chinese language processing and Chinese *** reviewed the application of functional MRI(fMRI)in such studies and some essential findings on brain systems in processing ***,for example,the application of task fMRI and resting-state fMRI in observing the process of reading and writing the logographic characters and producing or listening to the tonal *** cognitive neuroscience and several potential research directions around brain and Chinese language were discussed,which may be informative for future research.

关键词： Functional MRI Language task Chinese language processing human brain Resting-state

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brain-Inspired Artificial Intelligence:Advances and Applications

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Aerospace China 2021年第1期22卷 12-19页

作者： IA Tianyuan FAN Chaoqiong WANG Lina WANG Liya WU Xia School of Artificial Intelligence Beijing Normal UniversityBeijing 100875 Administration for Research and Development Beijing Normal UniversityBeijing 100875 National Key Laboratory of Science and Technology on Aerospace Intelligence Control Beijing 100854 Beijing Aerospace Automatic Control Institute Beijing 100070

Recent advances in Artificial Intelligence(AI)have indicated that inspirations from the brain can effectively improve the level of intelligence for AI computational models,even if just local and partial ***,realizing and exceeding intelligence at a human level still needs a deeper investigation and inspirations from the *** goal of brain-inspired intelligence is to achieve human intelligence inspired from brain neural mechanism and cognitive behavior *** this end,in this paper we introduce the relationship between AI and neuroscience,the current status of brain-inspired intelligence,the future work in intelligent control systems,and its profound influence in other fields.

关键词： artificial intelligence brain-inspired intelligence neuroscience human brain

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Astrocytic clasmatodendrosis in the cerebral cortex of methamphetamine abusers

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Forensic Sciences Research 2017年第3期2卷 139-144页

作者： Zhiyong Zhang Qingjin Gong Xueying Feng Dongchuan Zhang Li Quan Department of Forensic Pathology Zhongshan School of MedicineSun Yat-Sen UniversityGuangzhouChina Forensic Science Center Shunde Branch of Foshan Public Security BureauFoshanChina Shanghai Key Laboratory of Crime Scene Evidence Shanghai Institute of Forensic ScienceShanghaiChina

Postmortem investigation of methamphetamine(MA)abuse is an important task in forensic *** present study investigated morphological changes in the astrocytes in the parietal cerebral cortex of MA *** fibrillary acidic protein immunoreactivity in the cerebral cortex was examined in forensic autopsy cases for MA-detected group and control *** astrocytes(including those with swollen cell bodies and disintegrating distal processes)were frequently observed in the cerebral cortex of MA *** analysis using a colour image processor showed a concomitant increase in the astrocyte area and astrocyte-to-vessel area ratio(size and number of astrocytes)in the grey matter in acute MA fatality and other MA-involved cases,although the astrocyte area(size)was also increased in cases of *** total astrocyte area(size)in the white matter was significantly higher in MA fatalities and asphyxia than in the other groups involving MA *** indices were independent of blood MA level,age,sex,survival or postmortem *** observations suggest the increasing number and hypertrophic changes of astrocytes in the grey matter in MA abusers can be the outcome of long-term abuse,while disintegrating distal processes may exist only in acute fatal MA intoxication.

关键词： Forensic science forensic pathology immunohistochemistry methamphetamine human brain astrocyte clasmatodendrosis

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Copper interactions with DNA of chromatin and its role in neurodegenerative disorders

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Journal of Pharmaceutical Analysis 2013年第5期3卷 354-359页

作者： M.Govindaraju H.S.Shekar S.B.Sateesha P.Vasudeva Raju K.R.Sambasiva Rao K.S.J.Rao A.J.Rajamma Molecular Biophysics Unit Indian Institute of Science Department of Pharmacy Practice KIMS Hospital and Research CenterVIPS Department of Pharmaceutics Acharya & B.M.Reddy College of Pharmacy Department of Neuroscience Medical University of South Carolina Department of Biotechnology Acharya Nagarjuna University Centre for Neuroscience Institute for Scientifc Research and Technological services INDICASAT-AIP Department of Pharmacognosy KLEU's College of Pharmacy

In this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm that binding of copper to bases of DNA in chromatin is concentration dependent. Binding efficiency of Cu2~ ions to DNA is increased in proportion to the degree of unwinding of the double helix induced by denaturation. Altered B-DNA conformation will alter the integrity of DNA which may affect the normal process of DNA replication and transcription. Copper induced DNA damage in the brain may cause neurotoxicity and the neuronal cell death and is implicated in Alzheimer＇s disease and other neurological disorders.

关键词： human brain Chromatin DNA Copper Neurodegenerative disorders

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Lagged Coherence of Photon Emissions and Spectral Power Densities between the Cerebral Hemispheres of human Subjects during Rest Conditions: Phase Shift and Quantum Possibilities

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World Journal of Neuroscience 2016年第2期6卷 119-125页

作者： J. N. Costa B. T. Dotta M. A. Persinger Behavioural Neuroscience Program Laurentian University Sudbury Canada Biology Department Laurentian University Sudbury Canada Psychology Department Laurentian University Sudbury Canada Biomolecular Sciences Program Laurentian University Sudbury Canada

Photon counts about 15 cm from the left and right sides of the head while subjects sat quietly during baseline conditions within a hyper-dark chamber were measured by photomultiplier units. Lag/lead analyses for photon emissions between the two hemispheres indicated a weak but statistically significant correlation between the amplitude fluctuations that were separated by about 800 to 900 ms. Analyses of the spectral power densities of photon amplitude variations from the left and right hemispheres revealed peak values between 2 and 3 Hz which were equivalent to a difference of about 900 ms. The radiant flux densities were estimated to be in the order of 10?12 W?m?2 and to include the equivalence of about 107 neurons. Our calculations, which accounted for the small magnitude of the strength of the interhemispheric coefficients, suggest that the coherence could be strongly correlated with processes associated with the unmyelinated axons with diameters between 400 to 800 nm, the visible wavelengths, within the corpus callosum. When the ratio of the phase shift was applied to the Aharanov-Bohm equation, the time required for a photon-related electron to be within a cerebral magnetic field was the same duration as a single orbit of an electron and a photon’s traversal latency across a neuronal plasma membrane. We suggest that the peak photon decoherence between the two cerebral hemispheres may reveal a neuronal-quanta substrate to the conditions associated with consciousness.

关键词： Biophotons Interhemispheric Correlations Imagination human brain Quantitative EEG (QEEG) Visualization Corpus Callosum Aharanov-Bohm Effect

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Comparative study of the sectional slice of the anterior commissure and the internal capsule with its MRI images

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中国民康医学 2015年第14期 180-181页

作者：王单单 MA Wenyi Zhang Xiaoyang YUAN Lixiang YUAN Wu LI Yunsheng Department of Anatomy and Histo - embryology Tianjin Medical University Department of Medical Imaging and Nuclear Medicine Tianjin First Center Hospital

Objective:The brain of 100 normal persons were performed MRI scan and image analysis.12adult female brain specimens fixed by formalin,were made into the thickness of 0.5mm by celloidin embedding *** analyzed the anatomical position of the relationship about the anterior limb of internal capsule and the anterior commissure in eollodion-embedded plans,and then compared with the brain MRI of normal *** also further compared the statistical differences of the internal capsule’s *** research aimed to provide a reliable sectional anatomic basis for the study of the central nervous system and deep brain stimulation to treat the mental neurological ***:*** observation of celloid in brain slices horizontal section:Approximately 130 slices of each specimen,from the parietal lobe,the internal capsule was the typical structure"><"on the level of about 35 *** the level of about 41mm,the anterior commissure was"arc"through the bottom head of the caudate nucleus connecting the bilateral anterior limb,which located between the caudate nucleus and the lentiform *** posterior limb of internal capsule situated between the dorsal thalamus and the lentiform nucleus on the level of about 46 *** section:about 150 slices of per specimen,from the former lateral ventricle horn back,on the level of about 16 mm the anterior commissure was"arch"connecting the anterior *** 28 mm dimension,the interior capsule fore limb located between the caudate nucleus and the putamen,the posterior limb of internal capsule located between the globus pallidus and the dorsal thalamus,extending down to the cerebral *** section:about 180 slices of per specimen,from the outside to the inside at the beginning of the temporal lobe,the corona radia taextends between the putamen and dorsal thalamus,and then formsthe posterior limb of the internal capsule at the level of about 21 *** 25 mm level,fore limb located between the caudate n

关键词： human brain Anterior commissure Internal capsule Celloid in MRI three-dimensional reconstruction Volumetric analysis

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