Copper interactions with DNA of chromatin and its role in neurodegenerative disorders
Copper interactions with DNA of chromatin and its role in neurodegenerative disorders作者机构：Molecular Biophysics Unit Indian Institute of Science Department of Pharmacy Practice KIMS Hospital and Research CenterVIPS Department of Pharmaceutics Acharya & B.M.Reddy College of Pharmacy Department of Neuroscience Medical University of South Carolina Department of Biotechnology Acharya Nagarjuna University Centre for Neuroscience Institute for Scientifc Research and Technological services INDICASAT-AIP Department of Pharmacognosy KLEU's College of Pharmacy
出 版 物：《Journal of Pharmaceutical Analysis》 (药物分析学报（英文版）)
年 卷 期：2013年第3卷第5期
页 面：354-359页
学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学]
主 题：Human brain Chromatin DNA Copper Neurodegenerative disorders
摘 要：In this study, we have demonstrated the conformational changes to DNA induced by abnormal interactions of copper using circular dichroism, in combination with UV-absorbance and fluorescence spectroscopy. Results confirm that binding of copper to bases of DNA in chromatin is concentration dependent. Binding efficiency of Cu2~ ions to DNA is increased in proportion to the degree of unwinding of the double helix induced by denaturation. Altered B-DNA conformation will alter the integrity of DNA which may affect the normal process of DNA replication and transcription. Copper induced DNA damage in the brain may cause neurotoxicity and the neuronal cell death and is implicated in Alzheimer＇s disease and other neurological disorders.
维普期刊数据库
同方期刊数据库