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Role of copper chelating agents: between old applications and new perspectives in neuroscience

Neural Regeneration Research 2025年第3期20卷 751-762页

作者： Rosalba Leuci Leonardo Brunetti Vincenzo Tufarelli Marco Cerini Marco Paparella Nikola Puvača Luca Piemontese Department of Pharmacy-Pharmaceutical Science University of Bari Aldo MoroBariItaly Department of Precision and Regenerative Medicine and Jonian Area(DiMePRe-J) Section of Veterinary Science and Animal ProductionUniversity of Bari Aldo MoroBariItaly Department of Engineering Management in Biotechnology Faculty of Economics and Engineering Management in Novi SadUniversity Business Academy in Novi SadNovi SadSerbia

The role of copper element has been an increasingly relevant topic in recent years in the fields of human and animal health, for both the study of new drugs and innovative food and feed supplements. This metal plays an important role in the central nervous system, where it is associated with glutamatergic signaling, and it is widely involved in inflammatory processes. Thus, diseases involving copper(Ⅱ) dyshomeostasis often have neurological symptoms, as exemplified by Alzheimer's and other diseases(such as Parkinson's and Wilson's diseases). Moreover, imbalanced copper ion concentrations have also been associated with diabetes and certain types of cancer, including glioma. In this paper, we propose a comprehensive overview of recent results that show the importance of these metal ions in several pathologies, mainly Alzheimer's disease, through the lens of the development and use of copper chelators as research compounds and potential therapeutics if included in multi-target hybrid drugs. Seeing how copper homeostasis is important for the well-being of animals as well as humans, we shortly describe the state of the art regarding the effects of copper and its chelators in agriculture, livestock rearing, and aquaculture, as ingredients for the formulation of feed supplements as well as to prevent the effects of pollution on animal productions.

关键词： agriculture Alzheimer's disease chelators copper feed supplements multi-target

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Role of copper in central nervous system physiology and pathology

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Neural Regeneration Research 2025年第4期20卷 1058-1068页

作者： Martina Locatelli Cinthia Farina Institute of Experimental Neurology Division of NeuroscienceIstituto di Ricovero e Cura a Carattere Scientifico(IRCCS)San Raffaele Scientific InstituteMilanItaly Vita-Salute San Raffaele University MilanItaly

copper is a transition metal and an essential element for the organism,as alterations in its homeostasis leading to metal accumulation or deficiency have pathological effects in several organs,including the central nervous *** copper dysregulations have been evidenced in two genetic disorders characterized by mutations in the copper-ATPases ATP7A and ATP7B,Menkes disease and Wilson’s disease,respectively,and also in multifactorial neurological disorders such as Alzheimer’s disease,Parkinson’s disease,amyotrophic lateral sclerosis,and multiple *** review summarizes current knowledge about the role of copper in central nervous system physiology and pathology,reports about unbalances in copper levels and/or distribution under disease,describes relevant animal models for human disorders where copper metabolism genes are dysregulated,and discusses relevant therapeutic approaches modulating copper ***,alterations in copper metabolism may contribute to the etiology of central nervous system disorders and represent relevant therapeutic targets to restore tissue homeostasis.

关键词： astrocytes central nervous system copper cuprizone multiple sclerosis myelin neurodegenerative disorders

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copper

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China Nonferrous Metals Monthly 1995年第11期 12-14页

Chinese copper prices rose sharplyin mid-October 1993 synchronizedwith international market ***

关键词： over copper

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copper-comprising nanocrystals as well-defined electrocatalysts to advance electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2021年第11期30卷 71-102,I0002页

作者： Jianfeng Huang Tianyi Yang Ke Zhao Shuangqun Chen Qin Huang Yu Han Multi-scale Porous Materials Center Institute of Advanced Interdisciplinary StudiesSchool of Chemistry and Chemical EngineeringChongqing UniversityChongqing 400044ChinaAdvanced Membranes and Porous Materials CenterKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia

In the continuous development of electrochemical CO_(2) reduction (ECR), Cu-based electrocatalysts have received great attention, due to their unique ability to produce high value-added multicarbon products. Of particular interest are various Cu-comprising nanocrystals, not only because they usually show better catalytic properties than bulk materials, but also because their well-defined structures and highly tunable compositions facilitate in-depth mechanistic studies. This review aims to summarize the latest developments of electrocatalysts for ECR, with a focus on systems using Cu-comprising nanocrystals. We first give a general introduction to the field of ECR, covering the significance of this process, reaction mechanisms, catalyst evaluation criteria, and electrolytic cell configurations. Next, we discuss Cu-comprising nanocrystals developed for ECR by categorizing them into four groups: monometallic copper, copper-containing bimetals/multimetals, copper compounds, and copper–metal oxide hybrids;among these groups, we choose representative examples for detailed discussion on the synthetic methods, structural and compositional reaction sensitivities, and catalyst evolution during ECR. In the last section, we outline the challenges in this field from the fundamental and applicative aspects, and give perspectives on the expansion of catalyst varieties, the identification and preservation of active sites, and the exploration of industrially relevant operations for these nanocrystals. We hope the insights provided in this review will inspire the design and development of next-generation catalysts for ECR.

关键词： copper Nanocrystals Electrocatalysts Carbon-dioxide reduction Restructuring

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copper solvent extraction from alkaline cyanide solution with guanidine extractant LIX 7950

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Transactions of Nonferrous Metals Society of China 2010年第6期20卷 1136-1140页

作者： F.XIE D.B.DREISINGER Department of Materials Engineering University of British Columbia

The use of the guanidine extractant LIX 7950 extracting copper and cyanide from alkaline cyanide solution was *** extraction of copper and cyanide under different initial copper and extractant concentrations was examined and the stoichiometric extraction constant of Cu(CN)32- with LIX 7950 was *** the distribution coefficient and the stoichiometric extraction constant of Cu(CN)3 2-with LIX 7950 decrease when the temperature is varied from 25℃to 45℃, indicating the extraction process is *** calculated enthalpy change of the reaction(-HΘ)is about-190 kJ/*** copper extraction isotherms under different molar ratios of cyanide to copper are *** preferential extraction of Cu(CN)32- over Cu(CN)4 3-and CN -has been confirmed and a high cyanide-to-copper molar ratio tends to suppress copper loading. The loaded copper and cyanide can be stripped efficiently by the moderately strong NaOH solutions(0.5-1.0 mol/L)and the presence of NaCN in the stripping solution facilitates copper stripping.

关键词： copper cyanide solvent extraction guanidine

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copper-catalyzed direct acyloxylation of C(sp^2)–H bonds with Benzoic acids

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Science China Chemistry 2015年第8期58卷 1302-1309页

作者： Sheng Zhao Fa-Jie Chen Bin Liu Bing-Feng Shi Department of Chemistry Zhejiang University

A copper-catalyzed acyloxylation of C(sp2)–H bond with sterically bulky benzoic acids was *** protocol is compatible with a broad range of functional groups and could proceed in gram scale,providing an efficient and ... 详细信息

关键词： copper C-H activation acyloxylation ester bidentate

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copper-catalyzed 1,1-difunctionalization of terminal alkynes: a three-component reaction for the construction of vinyl sulfones

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Science China Chemistry 2019年第7期62卷 904-908页

作者： Qi Sun Linge Li Liyan Liu Yu Yang Zhenggen Zha Zhiyong Wang Hefei National Laboratory for Physical Sciences at Microscale CAS Key Laboratory of Soft Matter Chemistry & Center for Excellence in Molecular Synthesis of Chinese Academy of Sciences Collaborative Innovation Center of Suzhou Nano Science and Technology & School of Chemistry and Materials Science in University of Science and Technology of China

A copper-catalyzed 1,1-difunctionalization of terminal alkynes was achieved via a three-component reaction, providing a variety of vinyl sulfones with good yields and excellent chemo-and stereoselectivity. Preliminary mechanistic studies indicated that the reaction probably underwent a Cu-catalyzed formal C–H insertion to produce an allene intermediate, which was then trapped by a sulfonyl anion to give the corresponding product.

关键词： copper terminal alkynes germinal difunctionalization multicomponent reaction vinyl sulfones

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copper Adsorption on Olivine

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International Journal of Minerals,Metallurgy and Materials 2000年第4期14卷 237-241页

作者： Lei Shao, Rolf A. Kleiv, Kunt L. Sandvik, Cunyi Song, Shouci Lu ( Resources Engineering School, University of Science and Technology Beijing, Beijing 100083, China Department of Geology and Mineral Resources Engineering, Norwegian University of Science a Resources Engineering School University of Science and Technology Beijing Beijing 100083 China Department of Geology and Mineral Resources Engineering Norwegian University of Science and Technology 7034 Trondheim Norway

copper adsorption on olivine supplied by the A/S Olivine Production Plant at Aheim in western Norway was studied. The factors were evaluated which affect the uptake of copper. It is shown that the equilibrium pH of aqueous solution has the greatest influence on copper adsorption thanks to the competitive adsorption between proton and copper ions, and the adsorption of copper to olivine increases rapidly with pH increasing from 4 to 6. Moreover, initial copper concentration and olivine dose possess significant effect on copper adsorption, for the adsorption rate of copper increases with olivine dose increasing or initial copper concentration decreasing at the same pH. In addition, the ionic strength effect on the adsorption was also investigated, but it owns little effect on the adsorption process of copper due to the formation of inner sphere adsorption of copper on olivine. The experimental data show that olivine has a high acid buffer capacity and is an effective adsorbent for copper.

关键词： copper adsorption olivine, ionic strength acid mine drainage

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copper smelter slag treatment by ammonia solution:Leaching process optimization

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Journal of Central South University 2017年第12期24卷 2799-2804页

作者： R. Nadirov L. Syzdykova A. Zhussupova Department of General and Inorganic Chemistry al-Farabi Kazakh National University Almaty 050040 Kazakhstan Department of Physical Chemistry Catalysis and Petrochemistry al-Farabi Kazakh National UniversityAlmaty 050040 Kazakhstan

The feasibility of copper smelter slag processing by ammonia solution treatment was investigated. The central composite rotatable design(CCRD) and approximation method were used to determine the optimum conditions of zinc and copper recovery to a solution. The experimental design was done at five levels of the four operating parameters which were the initial concentration of NH–3, the initial Cl ions concentration, leaching time and solid/liquid ratio. Two mathematical models describing dependence of metal recovery on the operating parameters were obtained. The models are successful in predicting the responses. It was found that optimal parameters for zinc and copper recovery are as follows(values for copper are given in brackets): initial CNH3 17.1%(19.9%), initial CCl– 160 g/L(160 g/L), leaching process duration 4.56 h(4.13 h), solid/liquid ratio 0.39(0.53). The maximum Zn and Cu recoveries to solution, obtained experimentally under the conditions, are 81.16% and 56.48%, respectively.

关键词： copper slag ammonia solution metal recovery central composite design optimization

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copper Catalyzed Enantioconvergent Nucleophilic Substitutions

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Chinese Journal of Chemistry 2024年第10期42卷 1161-1174页

作者： Chunxi Huang Zilong Wan Aoping Zhu Caiyou Chen College of Chemistry and Molecular Sciences Wuhan UniversityWuhanHubei 430072China Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering Hubei UniversityWuhanHubei 430062China

As a versatile earth-abundant transition metal,Cu has long been widely applied in the C—C and C—X bond forming *** for now,low-valent Cu(Ⅰ)is known to reduce the redox active electrophiles via an SET pathway to give the corresponding radical and Cu(Ⅱ)*** resulting Cu(Ⅱ)species can interact with the radical via the out-sphere pathway,affording the coupling ***,Cu(Ⅱ)can trap the radical through the inner-sphere process to generate Cu(Ⅲ)species and then realize challenging bond formations due to the facile reductive elimination of Cu(Ⅲ)*** copper catalysis has been widely applied in arylations of various nucleophiles,copper-catalyzed enantioconvergent nucleophilic substitutions of racemic alkyl electrophiles have been less explored,likely due to the difficulties in overcoming the reduction potential of alkyl electrophiles,elimination of side reactions,and enantiomeric *** order to overcome the high reduction potential of alkyl electrophiles,the photo-induced strategy has been developed under mild *** alternative strategy with new anionic tridentate ligands has also been reported in this *** review summarizes recent developments in copper-catalyzed enantioconvergent nucleophilic substitutions of alkyl electrophiles by various nucleophiles to realize C—N,C—C,C—B,C—P and C—O bond formations and their brief mechanistic studies.

关键词： Enantioconvergent Nucleophilic substitution copper Radical reactions Photocatalysis Asymmetric catalysis

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