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ginsenoside rb1 improves brain,lung,and intestinal barrier damage in middle cerebral artery occlusion/reperfusion(MCAO/R)micevia the PPARγsignaling pathway

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Chinese Journal of Natural Medicines 2022年第8期20卷 561-571页

作者： SU Lin-Jie REN Yu-Chuan CHEN Zhuo MA Hui-Fen ZHENG Fan LI Fang ZHANG Yuan-Yuan GONG Shuai-Shuai KOU Jun-Ping Jiangsu Key Laboratory of TCM Evaluation and Translational Research Department of Pharmacology of Chinese Materia MedicaSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Ischemic stroke causes brain inflammation and multi-organ injury,which is closely associated with the peroxisome proliferator-activated receptor-gamma(PPARγ)signaling *** studies have indicated that ginsenoside rb1(Grb1)can protect the integrity of the blood-brain barrier after *** the current study,a mouse model of middle cerebral artery occlusion/reperfusion(MCAO/R)was established to determine whether Grb1 can ameliorate brain/lung/intestinal barrier damage via the PPARγsignaling ***(2,3,5-triphenyltetrazolium chloride,hematoxylin,and eosin)and Doppler ultrasonography were employed to detect pathological *** breakdown was investigated with the leakage of Evans Blue dye and the expression of TJs(tight junctions)and AJs(adherent junctions).Western blot and immunofluorescence were used to determine the levels of cell junction proteins,PPARγand NF-κ*** showed that Grb1 significantly mitigated multi-organ injury and increased the expression of cerebral microvascular,pulmonary vascular,and intestinal epithelial *** brain,lung,and intestinal tissues,Grb1 activated PPARγ,decreased the levels of phospho-NF-κB p65,and inhibited the production of proinflammatory cytokines,thereby maintaining barrier ***,co-treatment with Grb1 and the PPARγantagonist GW9662 reversed the barrier-protective effect of *** findings indicated that Grb1 can improve stroke-induced brain/lung/intestinal barrier damagevia the PPARγpathway.

关键词： Focal ischemic stroke Brain/lung/intestinal barriers ginsenoside rb1 PPARγ

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ginsenoside rb1 improves energy metabolism after spinal cord injury

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Neural Regeneration Research 2023年第6期18卷 1332-1338页

作者： Shan Wen Zhi-Ru Zou Shuai Cheng Hui Guo Heng-Shuo Hu Fan-Zhuo Zeng Xi-Fan Mei Department of Orthopedics Third Affiliated Hospital of Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina Key Laboratory of Medical Tissue Engineering of Liaoning Province Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina Pharmacy School Jinzhou Medical UniversityJinzhouLiaoning ProvinceChina

Mitochondrial damage caused by oxidative stress and energy deficiency induced by focal ischemia and hypoxia are important factors that aggravate *** have shown that ginsenoside rb1 has neurotrophic and neuroprotective ***,whether it influences energy metabolism after spinal cord injury remains *** this study,we treated mouse and cell models of spinal cord injury with ginsenoside *** found that ginsenoside rb1 remarkably inhibited neuronal oxidative stress,protected mitochondria,promoted neuronal metabolic reprogramming,increased glycolytic activity and ATP production,and promoted the survival of motor neurons in the anterior horn and the recovery of motor function in the hind *** sirtuin 3 regulates glycolysis and oxidative stress,mouse and cell models of spinal cord injury were treated with the sirtuin 3 inhibitor *** Sirt3 expression was suppressed,we found that the therapeutic effects of ginsenoside rb1 on spinal cord injury were remarkably ***,ginsenoside rb1 is considered a potential drug for the treatment of spinal cord injury,and its therapeutic effects are closely related to sirtuin 3.

关键词： axon growth ginsenoside rb1 glycolysis metabolic reprogramming mitochondrion neuroprotection oxidative stress oxygen and glucose deprivation Sirt3 spinal cord injury

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ginsenoside rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction

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Science China(Life Sciences) 2022年第11期65卷 2301-2315页

作者： Ping Zhou Feng Deng Zi Yang Canhui Cao Hongcui Zhao Fenting Liu Ke Zhong Lin Fu Tianliu Peng Di Sun Hui Liu Rong Li Yang Yu Center for Reproductive Medicine Department of Obstetrics and GynecologyPeking University Third HospitalBeijing 100191China Key Laboratory of Assisted Reproduction(Peking University) Ministry of EducationBeijing 100191China Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology Beijing 100191China National Clinical Research Center for Obstetrics and Gynecology(Peking University Third Hospital) Beijing 100191China Clinical Stem Cell Research Center Peking University Third HospitalBeijing 100191China

ginsenoside rb1 shows a strong antioxidant effect and has potential activation effects on *** aim of the present study was to investigate the protective effect of rb1 on age-related ovarian granulosa cell *** granulosa cells(GCs)were obtained from 50 young women(≤30 years)and 50 aged women(≥38 years)at an IVF *** and aged ICR mice were administered with or without rb1(10 mg kg^(-1),i.p.)for 2 *** protective effects of rb1 were investigated and the role of rb1 on the modulation of Akt-FoxO1 interaction was determined with immunofluorescence,Western blotting,immunoprecipitation,si RNA silencing and pharmacological ***1 effectively decreased LDH and MDA,and reversed the apoptotic-related protein levels in h GL cells from old *** results were found in *** addition,the mitochondrial membrane potential was restored and the overaccumulation of ROS was reversed by ***1 preserved peroxide-impaired Akt activation,to some extent,by increasing phosphorylation at ***1 also facilitated p-Akt binding to FoxO1 and promoted the phosphorylation of *** RNA silencing of Akt,Akt inhibitor LY294002,and FoxO1 inhibitor AS1842856 attenuated the effects of *** rb1 inhibits age-related GCs oxidative damage by activating Akt phosphorylation at Ser473 and by further interaction with FoxO1.

关键词： ginsenoside rb1 oxidative stress aging granulosa cell Akt FoxO1

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ginsenoside rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 744-757页

作者： Lifan Lin Xinmiao Li Yifei Li Zhichao Lang Yeping Li Jianjian Zheng Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Department of Urology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China

Liver fibrosis is primarily driven by the activation of hepatic stellate cells(HSCs),a process associated with *** rb1(Grb1),a major active component extracted from Panax ginseng,inhibits HSC ***,the potential role of Grb1 in mediating HSC ferroptosis remains *** study examined the effect of Grb1 on liver fibrosis both in vivo and in vitro,using CCl4-induced liver fibrosis mouse model and primary HSCs,LX-2 *** findings revealed that Grb1 effectively inactivated HSCs in vitro,reducing alpha-smooth muscle actin(a-SMA)and type I collagen(Col1A1)***,Grb1 significantly alleviated CCl4-induced liver fibrosis in *** a mechanistic standpoint,the ferroptosis pathway appeared to be central to the antifibrotic effects of ***,Grb1 promoted HSC ferroptosis both in vivo and in vitro,characterized by increased glutathione depletion,malondialdehyde production,iron overload,and accumulation of reactive oxygen species(ROS).Intriguingly,Grb1 increased Beclin 1(BECN1)levels and decreased the System Xc-key subunit *** experiments showed that BECN1 silencing inhibited Grb1-induced effects on HSC ferroptosis and mitigated the reduction of SLC7A11 caused by ***,BECN1 could directly interact with SLC7A11,initiating HSC *** conclusion,the suppression of BECN1 counteracted the effects of Grb1 on HSC inactivation both in vivo and in ***,this study highlights the novel role of Grb1 in inducing HSC ferroptosis and promoting HSC inactivation,at least partly through its modulation of BECN1 and SLC7A11.

关键词： ginsenoside rb1 Ferroptosis Liver fibrosis Hepatic stellate cells

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ginsenoside rb1,a Panoxadiol Saponin against Oxidative Damage and Renal Interstitial Fibrosis in Rats with Unilateral Ureteral Obstruction

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Chinese Journal of Integrative Medicine 2009年第2期15卷 133-140页

作者：谢席胜刘衡川杨满左川邓尧樊均明 Department of Nephrology West China HospitalSichuan University Department of Medicine Technology West China School of Public HealthSichuan University State Key Laboratory of Biotherapy of Human Disease West China HospitalSichuan University

Objective:To investigate the possible protective effect and mechanism of ginsenoside rb1 against oxidative damage and renal interstitial fibrosis on rats with unilateral ureteral obstruction(UUO). Methods:In total,80 male rats were randomly divided into 4 groups,20 in each group:the sham operated group (SOR),UUO group,UUO with ginsenoside rb1 treatment group(treated with intraperitoneal injection of 50 mg/ kg daily) and UUO with Losartan treatment group(as the positive control,treated with 20 mg/kg by gastr...

关键词： ginsenoside rb1 unilateral ureteral obstruction oxidative stress transforming growth factor beta1 p47phox

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ginsenoside rb1 Protects Human Umbilical Vein Endothelial Cells against High Glucose-Induced Mitochondria-Related Apoptosis through Activating SIRT3 Signalling Pathway

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Chinese Journal of Integrative Medicine 2021年第5期27卷 336-344页

作者： KE Shi-ye YU Shu-jie LIU Ding-hui SHI Guang-yao WANG Min ZHOU Bin WU Lin SONG Zhi-ming ZHU Jie-ming WU Chao-dong QIAN Xiao-xian Department of Cardiology the Third Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510630China Department of Cardiology the Eighth Affiliated Hospital of Sun Yat-Sen UniversityShenzhenGuangdong Province 518033China Department of Cardiology the First Affiliated Hospital of Henan UniversityKaifengHenan Province 475001China Department of Nutrition and Food Science Texas A&M UniversityCollege StationTX 77843United States of America Institute of Integrated Traditional Chinese and Western Medicine Sun Yat-Sen UniversityGuangzhou 510630China

Objective:To investigate whether ginsenoside rb1(rb1)can protect human umbilical vein endothelial cells(HUVECs)against high glucose-induced apoptosis and examine the underlying ***:HUVECs were divided into 5 groups:control group(5.5 mmol/L glucose),high glucose(HG,40 mmol/L)treatment group,rb1(50μmol/L)treatment group,rb1 plus HG treatment group,and rb1 and 3-(1 H-1,2,3-triazol-4-yl)pyridine(3-TYP,16μmol/L)plus HG treatment *** viability was evaluated by cell counting kit-8 *** and intracellular reactive oxygen species were detected by Mito Sox Red mitochondrial superoxide indicator and dichloro-dihydro-fluorescein diacetate assay,*** V/propidium iodide staining and fluorescent dye staining were used to measure the apoptosis and the mitochondrial membrane potential of HUVECs,*** protein expressions of apoptosis-related proteins[Bcl-2,Bax,cleaved caspase-3 and cytochrome c(Cyt-c)],mitochondrial biogenesis-related proteins[proliferator-activated receptor gamma coactivator 1-alpha,nuclear respiratory factor-1 and mitochondrial transcription factor A],acetylation levels of forkhead box O3 a and SOD2,and sirtuin-3(SIRT3)signalling pathway were measured by immunoblotting and ***:rb1 ameliorated survival in cells in which apoptosis was induced by high glucose(Prb1,mitochondrial and intracellular reactive oxygen species generation and malondialdehyde levels were decreased(Prb1 preserved the mitochondrial membrane potential and reduced the release of Cyt-c from the mitochondria into the cytosol(Prb1 upregulated mitochondrial biogenesis-associated proteins(Prb1 were correlated with SIRT3 signalling pathway activation(Prb1 against high glucose-induced mitochondria-related apoptosis wa

关键词： ginsenoside rb1 high glucose human umbilical vein endothelial cells apoptosis mitochondria SIRT3 signalling pathway

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ginsenoside rb1 attenuates lipopolysaccharide-induced chronic neuroinflammation in mice by tuning glial cell polarization

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Journal of Traditional Chinese Medical Sciences 2022年第4期9卷 383-391页

作者： Yushu Liu Juan Li Xi Wang Ying Liu Chao Zhang Hlupheka Chabalala Minke Tang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing102488China IK-Based Technology Innovation Department of Science and TechnologyPretoria0001South Africa

Objective:To evaluate whether ginsenoside rb1(rb1) can attenuate lipopolysaccharide(LPS)-induced chronic neuroinflammation in mice and to explore its relationship with glial cell ***:Intraperitoneal injection with an escalating dose of LPS was used to establish a chronic neuroinflammation model in *** LPS was initiated,10 or 20 mg/kg rbl,or sterile saline,was administered for 14 consecutive *** field test and beam walking test were used to monitor the changes in *** concentration of cytokines in the serum and brain were used to monitor the systemic inflammation and neuroinflammation,*** specific to each glial cell phenotype were used to investigate glial cell ***:Mice in the LPS group had reduced spontaneous activities and impaired beam walking *** obviously eased LPS-induced behavior distu *** the levels of serum cytokines,both tumor necrosis factor-α(TNF-α) and interleukin-1β(IL-1β) were significantly increased,while interleukin-10(IL-10) and transforming growth factor β(TGF-β) remarkably decreased after LPS treatment(all P rb1 treatment significantly attenuated LPS-induced serum cytokine changes(all P rbl treatment significantly inhibited LPS-induced inflammation in the brain(all P rb1 can attenuate chronic neuroinflammation induced by LPS in mice,which may be partially attributable to its fine tuning of microglia and astrocyte ***1 has potentia

关键词： Astrocytes Chronic neuroinflammation ginsenoside rb1 Glial cell polarization Lipopolysaccharide Microglia Neurodegenerative diseases

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ginsenoside rb1 Pretreatment Attenuates Myocardial Ischemia by Reducing Calcium/Calmodulin-Dependent Protein Kinase Ⅱ-Medicated Calcium Release

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World Journal of Traditional Chinese Medicine 2020年第3期6卷 284-294页

作者： Wen-Jun Zhou Juan-Li Li Qian-Mei Zhou Fei-Fei Cai Xiao-Le Chen Yi-Yu Lu Ming Zhao Shi-Bing Su Research Center for Traditional Chinese Medicine Complexity System Institute of Interdisciplinary Integrative Medicine ResearchShanghai University of Traditional Chinese MedicineShanghaiChina AntiCancer Inc.San DiegoUSA

Objective:The aim of this study was to investigate the protective effects of ginsenoside rb1 and assess whether these protective effects are related to calcium/calmodulin-dependent protein kinaseⅡ(Ca MKⅡ).Methods:A myocardial ischemia(IS)*** and a myocardial H9 C2 cell hypoxia model were *** was induced by occluding the left anterior descending artery for 120 *** rb1(10 mg/kg)was administered 30 min before ischemia induction,and the treatment continued for 7 ***:In the rat IS injury model,ginsenoside rb1 reduced myocardial infarct size,mean left ventricular diastolic pressure,incidence of arrhythmia,and levels of serum creatine kinase,lactate dehydrogenase,and ***,the mean left ventricular systolic pressure,and maximal rising and falling rates of ventricular pressure(±dp/dtmax)*** the myocardial H9 C2 cell hypoxia model,ginsenoside rb1 reduced intracellular calcium concentrations([Ca2+]i)during hypoxia,and markedly reversed the hypoxia-induced decrease in cell *** rb1 was involved in the downregulation of CaMKⅡand the ryanodine receptor,as well as hypoxia-induced H9 C2 cell ***:The findings of the present study suggest that ginsenoside rb1 attenuates MI injury in rats,partially through the downregulation of CaMKⅡexpression.

关键词： Calcium/calmodulin-dependent protein kinaseⅡ ginsenoside rb1 myocardial ischemia ryanodine receptor

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GPCR-Gs mediates the protective effects of ginsenoside rb1 against oxygen-glucose deprivation/re-oxygenation-induced astrocyte injury

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Journal of Traditional Chinese Medical Sciences 2024年第1期11卷 33-43页

作者： Xi Wang Ying Liu Juan Li Jiayu Xie Yi Dai Minke Tang School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Taihe Hospital Hubei University of MedicineShiyan 442000China School of Medicine Hyogo Medical UniversityNishinomiya 663-8501Japan

Objectives:To investigate whether the protective actions of ginsenoside rb1(rb1)on astrocytes are mediated through the G_(s)-type G-protein-coupled receptor(GPCR-G_(s)).Methods:Primary astrocyte cultures derived from neonatal mouse brain were *** injury was induced via oxygen-glucose deprivation/re-oxygenation(OGD/R).Cell morphology,viability,lactate dehydrogenase(LDH)leakage,apoptosis,glutamate uptake,and brain-derived neurotrophic factor(BDNF)secretion were assessed to gauge cell survival and *** blot was used to investigate the cyclic adenosine monophosphate(cAMP)and protein kinase B(Akt)signaling ***-G_(s)-specific inhibitors and molecular docking were used to identify target ***:rb1 at concentrations ranging from 0.8 to 5μM did not significantly affect the viability,glutamate uptake,or BDNF secretion in normal ***/R reduced astrocyte viability,increasing their LDH leakage and apoptosis *** also decreased glutamate uptake and BDNF secretion by these ***1 had protective effects of astrocytes challenged by OGD/R,by improving viability,reducing apoptosis,and enhancing glutamate uptake and BDNF ***,rb1 activated the cAMP and Akt pathways in these *** the GPCR-G_(s) inhibitor NF449 was introduced,the protective effects of rb1 completely disappeared,and its activation of cAMP and Akt signaling pathways was significantly ***:rb1 protects against astrocytes from OGD/R-induced injury through GPCR-G_(s) mediation.

关键词： Ginseng ginsenoside rb1 Receptor GPCR Astrocytes Neuroprotective effects

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ginsenoside rb1 improves postoperative fatigue syndrome by reducing skeletal muscle oxidative stress through activation of the PI3K/Akt/Nrf2 pathway in aged rats

Ginsenoside Rb1 improves postoperative fatigue syndrome by r...

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2014浙江省医学会肠外肠内营养学学术年会

作者：庄成乐毛翔宇刘舒陈伟哲黄冬冬张昌静陈必成沈贤余震温州医科大学附属第一医院胃肠外科

ginsenoside rb1 is reported to possess anti-fatigue activity,but the mechanisms remain *** aim of this study was to investigate the molecular mechanisms responsible for the anti-fatigue effect of ginsenoside rb1 on postoperative fatigue syndrome induced by major small intestinal resection(MSIR)in aged *** rats with MSIR were administrated with ginsenoside rb1(15 mg/kg)once a day from 3 days before surgery to the day of sacrifice,or with saline as corresponding *** without MSIR but going through the same surgery procedure were administrated with saline as blank ***-fatigue effect was assessed by open field test;superoxide dismutase,reactive oxygen species and malondialdehyde in skeletal muscle were *** mRNA levels of Akt2 and Nrf2 in skeletal muscle were measured by real-time quantitative *** activation of Akt and Nrf2 were examined by western blot and *** results revealed that ginsenoside rbl significantly increased the journey and the rearing frequency,decreased the time of rest in aged rats with *** addition,ginsenoside rbl significantly reduced reactive oxygen species and malondialdehyde release and increased the superoxide dismutase activity of skeletal muscle in aged rats with *** rbl also increased the expression of Akt2 and Nrf2 mRNA,up-regulated Akt phosphorylation and Nrf2 nuclear *** findings indicate that ginsenoside rbl has an anti-fatigue effect on postoperative fatigue syndrome in aged rat,and the mechanism possibly involves activation of the PI3K/Akt pathway with subsequent Nrf2 nuclear translocation and induction of antioxidant enzymes.

关键词： ginsenoside rb1 Postoperative fatigue syndrome Oxidative stress PI3K/Akt Nrf2

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