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frontal lobe position after single-layer cadaveric dermal matrix repair of large anterior skull base defects

World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第1期8卷 36-41页

作者： Corinna G.Levine Abdullah N.Al-Rasheedi Alejandro Mantero Mohammad Al-Bar Roy R.Casiano Rhinology&Skull Base Surgery Department of OtolaryngologyUniversity of Miami Miller School of MedicineMiamiFloridaUSA Otolaryngology Head&Neck Surgery Jouf University-Medical CollegeSkakaSaudi Arabia Department of Public Health Sciences Biostatistics Collaboration and Consulting Core.MiamiFlorida.USA Otolaryngology King Fahad Hospital of the UniversityImam Abdulrahman Bin Faisal UniversityKhobarSaudi Arabia

Objective:Endoscopic repair of large anterior skull base(ASB)defects has excellent results when using multilayered repairs with a nasoseptal ***,in extensive intranasal tumors,a nasoseptal flap may not always be *** alternative option is a flexible single-layer ASB *** studies indicate low cerebrospinal fluid leak rates with a single-layer ***,the level of frontal lobe support,particularly the propensity for a significant inferior displacement of the frontal lobe,is not *** goal of this study is to determine the frontal lobe position after single-layer acellular dermal allograft repair in large ASB *** Design:Retrospective cohort ***:Tertiary care medical *** and Methods:This cohort study compares the frontal lobe position in adults who underwent endoscopic endonasal ASB tumor resection and single-layer cadaveric dermal matrix repair(ASB cohort)with control subjects without intracranial abnormalities(control cohort).The ASB cohort includes subjects with an ASB defect of≥5 cm anterior/posterior and≥1.5 cm wide and who had imaging at least 2 months after *** frontal lobe position is measured on sagittal CT/MRI using a reference line from the base of the sella to the nasion.A value of zero indicates that the inferior-most aspect of the frontal lobe is at the level of the nasion-sellar line.A positive value indicates that the frontal lobe is inferior to the nasion-sellar *** ASB cohort frontal lobe position is compared with the control cohort using the Mann-WhitneyU test.A priori we set an absolute difference of 5 mm as a clinically significant ***:The ASB cohort includes 47 subjects who are 57%male with an average age of 60 years(range:31-89 years).The most common ASB pathology is esthesioneuroblastoma(n=21)and 81%of the ASB cohort had postoperative *** control cohort includes 20 subjects who are 60%male,with a mean age of 45 years(range:19-74 years).The

关键词： anterior skull base cohort study frontal lobe skull base repair skull base tumor

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Electroacupuncture at the Wangu (GB 12) acupoint suppresses expression of inflammatory factors in the hippocampus and frontal lobe of rats with post-stroke depression

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Neural Regeneration Research 2011年第36期6卷 2839-2844页

作者： Rubo Sui Lei Zhang Department of Neurology First Affiliated Hospital of Liaoning Medical College Jinzhou 121001 Liaoning Province China Department of School of Nursing Liaoning Medical College Jinzhou 121001 Liaoning Province China

Electroacupuncture was performed at the Wangu （GB 12） acupoint, whose position is similar to the cerebellar fastigial nucleus in rats with post-stroke depression. Results showed that the expression of nuclear factor-κB and the levels of tumor necrosis factor-α and interleukin-1β decreased. Simultaneously, the extent of edema in the hippocampus and frontal lobe decreased, and the morphology of the nerve cells recovered to near normal. In addition, fluoxetine treatment displayed a similar effect on post-stroke depression as electroacupuncture at GB 12 acupoint. The results indicate that electroacupuncture at GB 12 acupoint can reduce the levels of cytokines in the hippocampus and frontal lobe of rats with post-stroke depression, and thus provide a neuroprotective effect on post-stroke depression.

关键词： post-stroke depression hippocampus frontal lobe cytokines electroacupuncture Wangu (GB 12) acupoint traditional Chinese medicine neural regeneration

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Combined effects of electroacupuncture and anti-depression drugs on the hippocampus and frontal lobe

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Neural Regeneration Research 2010年第22期5卷 1723-1727页

作者： Dongmei Duan Ya Tu Shuang Jiao Liping Chen Department of TCM of Nan Lou Chinese PLA General Hospital Beijing 100853 China School of Acupuncture and Moxibustion Beijing University of Chinese Medicine Beijing 100029 China

Electroacupuncture （EA） has been clinically used to treat depression and has resulted in favorable effects in China. However, results from animal studies and pathology do not reflect the influence of electroacupuncture treatment on in vivo physiological functions. To thoroughly and dynamically observe pathological changes during depression, the present study established EA ＋ fluoxetine and fluoxetine groups to observe depression in patients. 1H-magnetic resonance spectroscopy was utilized to determine the correlation between hippocampal frontal lobe metabolite changes and mental disorder scale. Results revealed significantly increased N-acetylaspartate （NAA）/creatine （Cr） in the bilateral hippocampus and right frontal lobe of depression patients treated with EA compared with fluoxetine. Changes in NAA/Cr in bilateral hippocampus and right frontal lobe in both groups, before and after treatment, negatively correlated with severity and curative effects. Choline/Cr changes in the bilateral frontal lobes of both groups were significant before and after treatment, but negatively correlated with curative effects. Choline/Cr changes in the bilateral hippocampus were significant in the EA ＋ fluoxetine group before and after treatment, but negatively correlated with severity and the curative effects of depression. These results demonstrate abnormal biochemical metabolism in bilateral frontal lobes and hippocampus of depression patients, and show that EA significantly altered biochemical indices in the frontal lobes and hippocampus compared with fluoxetine.

关键词： depression electroacupuncture fluoxetine hippocampus frontal lobe traditional Chinese medicine magnetic resonance spectroscopy neural regeneration

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Topographical Analysis of frontal lobe Executive Functions in Patients Following a Stroke

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World Journal of Neuroscience 2016年第2期6卷 143-150页

作者： Roberta Márcia Torres Kristiana Cerqueira Mousinho Liércio Pinheiro Nathália Costa Toledo Pacheco Piatti Taise Almeida Cavalcante Aline da Silva Amorim Ana Karolina Barros de Jesus Maria Wylianna Oliveira dos Santos Euclides Maurício Trindade Filho University Center CESMAC Maceió Brazil

Objective: This study aimed to carry out a topographical analysis of frontal lobe executive function components in post-stroke patients. Methods: A descriptive, cross-sectional study. The assessment using the WCST (Wisconsin Card Sorting Test) included sixteen patients with a clinical diagnosis of CVA and frontal lobe impairment. Results from the two groups were compared (patients with right frontal lobe impairment and patients with left frontal lobe impairment). Statistical analysis was performed using the program “Statistical Package for Social Sciences” (SPSS) Version 20.0. For comparison between groups was used Mann-Whitney test and considered the alpha level of 0.05 on the statistically significant results. Results: There was no statistically significant difference between the groups, thus showing that executive functions are symmetrically distributed across the frontal lobes. Conclusion: Executive functions are symmetrically organized across the two frontal lobes, since the comparison between the groups did not demonstrate a statistically significant difference for any of the variables of WSCT.

关键词： Executive Function Stroke frontal lobe Neuropsychology

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Intracranial pressure monitoring for special patterns of frontal lobe contusions

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Chinese Journal of Traumatology 2010年第1期13卷 51-54页

作者：董吉荣蔡学见王标王玉海时忠华刘斌蔡桑徐勤义 Neurosurgical Department of 101 Hospital of PLA Rescue Center of Craniocerebral Injuries in Army Wuxi 214044 China

Objective： To study the effect and indications ofintracranial pressure （ICP） monitoring for frontal lobe contusion patients. Methods： During January 2005-December 2008, 34 cases of frontal lobe contusion received ICP monitoring in our department （monitoring group）. Different treatment protocols were adopted according to the results of ICP. Mean-while 46 cases of same type of head-injured patients who did not undergo ICP monitoring served as control group. Results： We found that ICP elevated dramatically within 24 hours after head injury if the contusions were located in frontal longitudinal dehiscence, bilateral undersurface of frontal lobe or dispersed in bilateral lobe. After half a year follow-up and on the basis of Glasgow Coma Scale assessment, the monitoring group showed better outcome than the control group with good recovery in 24 cases （70.6%）, moderate disability in 7 cases （20.6%）, severe disability in 2 （5.88%） and death in 1 （2.94%）. The outcome of control group displayed good condition in 25 cases （54.3%）, moderate disabilities in 8 （17.4%）, severe disability in 7 （15.2%）, and death in 6 （13.0%）. Conclusions： frontal lobe contusions are vulnerable and complex head injuries, especially when the contusions are located in frontal longitudinal dehiscence, bilateral undersurface of frontal lobe or diffused in bilateral lobes. These patients should undergo ICP monitoring regardless of their consciousness status. IflCP elevates over 25 mm Hg, the craniotomy is mandatory and will markedly reduce the mortality and disability of these patients.

关键词： frontal lobe Contusions Intracranial pressure Craniotomy

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Impaired Social Cognition in Patients with Interictal Epileptiform Discharges in the frontal lobe

Impaired Social Cognition in Patients with Interictal Epilep...

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华东六省一市第二十三次神经病学学术会议暨2016年浙江省神经病学学术年会

作者： Ying Hu Yubao Jiang Panpan Hu Huijuan Ma Kai Wang Department of Neurology the First Affiliated Hospital of Anhui Medical University

Background:Patients with epilepsy frequently experience cognitive impairments,including impairments in social ***,there is a lack of direct examinations of the affective and cognitive aspects of social cognition in such *** neural correlates remain to be *** present study was designed to examine the degree of impairments in different aspects of social cognition including empathy,emotion recognition and theory of mind(ToM) in patients with *** addition,we further explored factors related to the impairments,highlighting the specific importance of the frontal *** and mGthods:After 24-hour EEG monitoring,53 patients with epilepsy were administered a neuropsychological battery of tests for basic intelligence assessment and then were tested with the Interpersonal Reactive Index,the "Yoni’’ task,the Emotion Recognition Test,the Reading the Mind in the Eyes test,and other neuropsychological *** clinical variables potentially affecting the ability to accomplish these tests were taken into *** divided the patients into those having frontal lobe interictal epileptiform discharges(frontal IEDs group) and those with seizures originating outside the frontal or temporal lobes(extra-frontal IEDs group).Sixty healthy individuals served as ***:The frontal IEDs group achieved the most severe deficits in emotion recognition,ToM,and cognitive empathy,while the affective empathy was ***,the performance scores of empathy in frontal IEDs group were selectively correlated with their executive functions scores,which are believed to be associated with orbitofrontal *** contrast,patients with epilepsies not originating from the frontal or temporal lobes may also be at risk of impairments in social cognition,albeit to a lesser ***:The preliminary findings suggest that patients with epilepsy,especially those having frontal lobe interictal epileptiform discharges,are associated w

关键词： Epilepsy Social cognition Theory of mind Empathy frontal lobe

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Cerebral tuberculoma located in left frontal lobe

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Chinese Medical Journal 2013年第3期126卷 600-600页

作者： Yan Hua Han Tong Wang Jin-huan Tianjin Huanhu Hosp Dept Neurosurg Tianjin 300060 Peoples R China Tianjin Med Univ Dept Radiol Gen Hosp Tianjin 300060 Peoples R China

To the editor： Tuberculosis of the central nervous system （CNS） is not commonly encountered compared to the involvement of other systems. Radiological diagnosis of a brain tuberculoma is difficult because the imaging presentation is varied and can be non-specific. We present a case of tuberculoma mimicking a high-grade glial tumor on magnetic resonance imaging （MRI） and clinical presentation.

关键词： Cerebra tuberculoma located frontal lobe

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Effect of acoustic stimuli in patients with disorders of consciousness: a quantitative electroencephalography study

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Neural Regeneration Research 2018年第11期13卷 1900-1906页

作者： Min Wu Wang-Xiao Bao Jie Zhang Yang-Fan Hu Jian Gao Ben-Yan Luo Department of Neurology&Brain Medical Centre First Affiliated HospitalSchool of MedicineZhejiang University Department of Computer Science Zhejiang University Department of Rehabilitation Hangzhou Hospital of Zhejiang Armed Police Corps

Auditory stimuli are proposed as beneficial neurorehabilitation methods in patients with disorders of consciousness. However, precise and accurate quantitative indices to estimate their potential effect remain scarce. Fourteen patients were recruited from the Neuro-Rehabilitation Unit of Hangzhou Hospital of Zhejiang Armed Police Corps of China. Altogether, there were seven cases of unresponsive wakefulness syndrome（five males and two females, aged 45.7 ± 16.8 years） and seven cases of minimally conscious state（six males and one female, aged 42.3 ± 20.8 years）. Simultaneously, fourteen healthy controls（10 males and 4 females, aged 51.7 ± 9.7 years） also participated in this case-control experiment. Brain response to music, subjects＇ own name, and noise was monitored by quantitative electroencephalography（QEEG） in the resting state and with acoustic stimulation. Predictive QEEG values in various brain regions were investigated. Our results show that cerebral activation was high in subjects stimulated by their own name, especially in the temporal lobe in patients with disorders of consciousness, and the frontal lobe in the control group. Further, during resting and stimulation, QEEG index（δ ＋ θ/α ＋ β ratio） negatively correlated with the Coma Recovery Scale-Revised score in traumatic disorders of consciousness patients. Hence, we speculate that a subject＇s own name might be an effective awakening therapy for patients with disorders of consciousness. Moreover, QEEG index in specific stimulation states may be used as a prognostic indicator for disorders of consciousness patients（sensitivity, 75%; specificity, 50%）.

关键词： nerve regeneration auditory stimulation disorders of consciousness frontal lobe neuroplasticity quantitative electroencephalography Coma Recovery Scale-Revised awakening music subjects own name white noise neural regeneration

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Regional volume changes of the brain in migraine chronification

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Neural Regeneration Research 2020年第9期15卷 1701-1708页

作者： Xiao-Yan Chen Zhi-Ye Chen Zhao Dong Meng-Qi Liu Sheng-Yuan Yu Department of Neurology First Medical Center of Chinese PLA General HospitalBeijingChina Department of Radiology First Medical Center of Chinese PLA General HospitalBeijingChina Department of Radiology Hainan Hospital of First Medical Center of Chinese PLA General HospitalSanyaHainan ProvinceChina

The pathophysiology of migraine is *** studies reveal functional and structural changes in the brains of migraine *** sought to explore regional volume differences in intracranial structures in patients with episodic and chronic *** episodic migraine patients,16 chronic migraine patients,and 24 normal controls were recruited and underwent 3.0 T MRI *** volumes of 142 brain regions were calculated by an automatic volumetric algorithm and compared with clinical *** demonstrated that the volumes of specific regions in the frontal and occipital lobes,and the right putamen,were increased and the volume of the fourth ventricle was decreased in the episodic migraine patients compared with *** volumes of the left basal forebrain,optic chiasm,and,the fourth ventricle were decreased in the chronic migraine patients,while the occipital cortex and the right putamen were *** to episodic migraine patiants,chronic migraine patients displayed larger left thalamus and smaller frontal *** analysis showed that headache frequency was negatively correlated with the volume of the right frontal pole,right lateral orbital gyrus,and medial frontal lobes and positively correlated with the volume of the left *** sleep disturbance score was negatively correlated with the volume of the left basal *** suggests that migraine patients have structural changes in regions associated with pain processing and modulation,affective and cognitive processing,and visual *** remodeling of selective intracranial structures may be involved in migraine *** study was approved by the Ethics Committee of Chinese PLA General Hospital(approval No.S2018-027-02)on May 31,2018.

关键词： brain volume chronic migraine frontal lobe magnetic resonance imaging migraine remodeling thalamus visual processing system

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Effects of special brain area regional cerebral blood flow abnormal perfusion on learning and memory function and its molecular mechanism in rats

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Frontiers in Biology 2008年第2期3卷 147-153页

作者： Lingbin KONG Zhiyin YANG Rui AN Shouhua DING Jining Medical College Shandong Institute of Behavioral Medical ScienceJining 272000China Department of Nuclear Medicine Union HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan 430030China

To study the effect of special brain area regional cerebral blood flow(rCBF)abnormal perfusion on learning and memory function and its molecular mechanism,64 adult male healthy Sprague-Dawley(SD)rats were randomly divided into two groups,the false operation group(control group)and the operation group(model group).After surgical operation,the operation group undertook bilateral common carotid artery permanent ligation,while the other group did *** and memory function were measured by Y-maze at 4 h,8 h,24 h and 3 d after surgical operation,*** rCBF of the right frontal lobe and hippocampus was also detected by the PerifluxPF model laser Doppler flowmetry,and the expressions of c-fos or c-jun or Bcl-2 and Bax were also measured by immune histochemistry S-P method *** showed that the rCBF of the right frontal lobe and hippocampus in the operation group was significantly lower than that in the false operation group(P,0.05).The learning indexes,error number(EN),day of reach standard and total reaction time(TRT)in the operation group,were significantly higher than that in the false operation group(P,0.05).However,the initiative evasion rate in the operation group was significantly lower than that in the false operation *** study also found that the rCBF was relatively more,the indexes(EN,the day of reach standard and TRT)relatively fewer,but the initiative evasion rate and the memory keeping rate were relatively *** positive expression and the average absorbency of Fos and Jun in the operation group were significantly higher than that in the false operation group(P<0.05).Furthermore,Bax and Bcl-2 positive cells were all increased over time in the operation group,and the expression ratio of Bax/Bcl-2 in the operation group was significantly higher than that in the false operation group(P<0.01).In conclusion,rCBF decrease can impair the learning and memory function in rats,which may be related to the increase of the expression

关键词： rCBF learning memory function correlation frontal lobe hippocampus molecular mechanism

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