Impaired Social Cognition in Patients with Interictal Epileptiform Discharges in the Frontal Lobe
作者单位：Department of Neurologythe First Affiliated Hospital of Anhui Medical University
会议名称：《华东六省一市第二十三次神经病学学术会议暨2016年浙江省神经病学学术年会》
会议日期：2016年
学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学]
关 键 词：Epilepsy Social cognition Theory of mind Empathy Frontal lobe
摘 要：Background:Patients with epilepsy frequently experience cognitive impairments,including impairments in social ***,there is a lack of direct examinations of the affective and cognitive aspects of social cognition in such *** neural correlates remain to be *** present study was designed to examine the degree of impairments in different aspects of social cognition including empathy,emotion recognition and theory of mind(ToM) in patients with *** addition,we further explored factors related to the impairments,highlighting the specific importance of the frontal *** and mGthods:After 24-hour EEG monitoring,53 patients with epilepsy were administered a neuropsychological battery of tests for basic intelligence assessment and then were tested with the Interpersonal Reactive Index,the Yoni’’ task,the Emotion Recognition Test,the Reading the Mind in the Eyes test,and other neuropsychological *** clinical variables potentially affecting the ability to accomplish these tests were taken into *** divided the patients into those having frontal lobe interictal epileptiform discharges(frontal IEDs group) and those with seizures originating outside the frontal or temporal lobes(extra-frontal IEDs group).Sixty healthy individuals served as ***:The frontal IEDs group achieved the most severe deficits in emotion recognition,ToM,and cognitive empathy,while the affective empathy was ***,the performance scores of empathy in frontal IEDs group were selectively correlated with their executive functions scores,which are believed to be associated with orbitofrontal *** contrast,patients with epilepsies not originating from the frontal or temporal lobes may also be at risk of impairments in social cognition,albeit to a lesser ***:The preliminary findings suggest that patients with epilepsy,especially those having frontal lobe interictal epileptiform discharges,are associated w