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Assessment of immunization procedures for foot-and-mouth disease in large-scale pig farms in China based on actual data and dynamics

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Animal diseases 2022年第1期2卷 45-60页

作者： Huarong Ren Zhen Jin Xin Pei Mingtao Li You ming Wang Juan Zhang Complex Systems Research Center Shanxi University030006 ShanxiChina Shanxi Key Laboratory of Mathematical Techniques and Big Data Analysis on disease Control and Prevention 030006 ShanxiChina School of Mathematical Sciences Shanxi University030006 ShanxiChina College of Mathematics Taiyuan University ofTechnology030024 ShanxiChina The Laboratory of Animal Epidemiological Surveillance China Animal Health&Epidemiology Center266032 ShandongChina.

foot-and-mouth disease(FMD)is an acute,highly infectious and pathogenic animal *** recent years,with the rapid development of the swine breeding industry in China,pig farms have shown a trend of larger-scale ***-scale pig farms employ standardized management,a high level of automation,and a strict_***,these farms have a large trading volume,and increased transmission intensity of FMD is noted inside the *** present,the main control measure against FMD is pig ***,a standard for immunization procedures is not available,and currently adopted immunization procedures have not been effectively and systematically *** a typical large-scale pig farm in China as the research subject and considering the breeding pattern,piggery structure,age structure and immunization procedures,an individual-based state probability model is established to evaluate the effectiveness of the immune *** on numerical simulation,it is concluded that the optimal immunization program involves primary immunization at 40 days of age and secondary immunization at 80 days of age for commercial *** boars and breeding sows are immunized 4 times a year,and reserve pigs are immunized at 169 and 259 days of *** to the theoretical analysis,the average control reproduction number of individuals under the optimal immunization procedure in the farm is *** the absence of immunization,the average is 1.7498,indicating that the epidemic cannot be controlled without immunization procedures.

关键词： Pig farm foot-and-mouth disease Individual-based state probability model Immunization procedure Infection probability Individual-based control reproduction number

Molecular and Serological Epidemiology of foot-and-mouth disease Virus in North Region of Cameroon

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Advances in Microbiology 2022年第10期12卷 579-595页

作者： Simon Jumbo Dickmu Julius Awah-Ndukum Niba Tatanja Aziwo Silas Lendzele Sevidzem Mohamed Moctar Mouliom Mouiche Carla Bravo de Rueda Labib Bakkali Kassimi Abel Wade Rebecca Garabed Abdul-Dahiru El-Yuguda Luis Rodriguez Saka Saheed Baba Laboratoire National Vétérinaire LANAVET Garoua Cameroon Department of Animal Production Technology College of Technology The University of Bamenda Bamenda Cameroon Institute of Research in Tropical Ecology (IRET) Libreville Gabon Ecole des Sciences et de Médecine Vétérinaire Université de Ngaoundéré Ngaoundere Cameroon Foreign Animal disease Research Unit United States Department of Agriculture Agricultural Research Service Plum Island Animal Disease Centre Greenport USA Agence Nationale de Sécurité Sanitaire de l’Alimentation de l’Environnement et du Travail Pierre et Marie Curie Maisons-Alfort France Department of Veterinary Preventive Medicine The Ohio State University Columbus USA Department of Veterinary Microbiology and Parasitology Faculty of Veterinary Medicine University of Maiduguri Maiduguri Nigeria

The serological prevalence of foot and mouth disease virus (FMDV) among the cattle population in the North region of Cameroon was determined using ELISA (Enzyme Linked Immunosorbent Assays) serological tests for structural as well as non-structural proteins. In these cattle, FMDV RNA was identified, amplified, sequenced and the sequences were used to construct a phylogenetic tree. A sedentary cattle population randomly selected from six veterinary centres in the North region was sampled twice, six months apart. High prevalence of FMDV antibody was recorded in the first (402/466 (85.84%)) and second (358/411 (86.90%)) sampling periods. There was no significant difference (P > 0.05) in prevalence of FMDV antibody between the two sampling periods. Goudali and Peulh breeds of cattle and animals of three to five years old were the most infected with FMDV and mostly in the months of May and August. A seroprevalence of 100% (n = 14) of FMDV against serotypes A and O was observed in sera from convalescent animals in the study area. FMDV antigen detection ELISA showed a prevalence of 18/37 (48.65%) for serotypes SAT1 (8.1%), SAT2 (35.1%), A (10.8%) and O (2.7%) among the clinically infected animals. There was no significant difference (P > 0.05) in prevalence of FMDV RNA between the sampling periods. A prevalence of FMDV RNA (17.5% (n = 120) and 16.7% (n = 240)) was observed among the sedentary animals that were sampled four to five months apart. FMDV RNA prevalence of 28/37 (75.6%) among clinically infected animals was also observed, thus confirming all the 12 outbreaks investigated. Sequence analysis of VP1 coding gene of the SAT2 serotype showed that it was homologous to the Libyan isolates (that caused epidemics in northern Africa in 2012) and also clustered with the serotypes isolated from both Nigeria and Sudan in 2007.

关键词： foot-and-mouth disease Seroprevalence Non-Structural Protein Structural Protein ELISA Sedentary Cattle North Cameroon

Geographic Information System to Monitor and Forecast the Influence of foot-and-mouth disease of Poultry and Cattle

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Economics World 2019年第3期7卷 134-139页

作者： Le Vu Truong Huynh Tan Hoi Department of IT FPT UniversityHo Chi MinhcityVietnam Department of Japanese FPT UniversityHo Chi MinhcityVietnam

The paper introduces the origin,technical features,scale,application efficiency of geographic information system(GIS)to monitor the situation and forecast the spread of foot-and-mouth disease of poultry and cattle—a technological product of Vietnam Software Academy for *** of the system will help the producers and managers to quickly capture the situation of raising poultry and cattle,vaccination results in the related territory,flu outbreaks,epidemic foot-and-mouth disease,and the spread of these two dangers as they arise,resulting in appropriate decisions and solutions in order to prevent,minimize the risk effectively.

关键词： foot-and-mouth disease GIS poultry and cattle solutions

Space-Time Analysis of foot-and-mouth disease from 2005 to 2014 among Cattle Populations in Benin:A Retrospective Study

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Open Journal of Animal Sciences 2017年第1期7卷 30-44页

作者： Nestor Noudeke Evelyne Houndje Olivier Zannou Ignace Dotche Issaka Youssao Souaibou Farougou Departement de Production et Sante Animales Ecole Polytechnique d’Abomey-CalaviUniversite d’Abomey-CalaviCotonouRepublique du Benin Direction de la Production Animale Ministere de l’Agriculturede l’Elevage et de la PecheCotonouRepublique du Benin

Many cases of foot-and-mouth disease (FMD) are reported every year in Benin. In order to elucidate the epidemiology of this disease, a space-time analysis was carried out in all the 77 municipalities of the country aiming to identify high risk areas as well as risk factors such as season and transhumance on the period of 2005 to 2014. Data were collected retrospectively from the Directory of Animal Production of Benin. The method of Kulldorff was used with the software SaTScanTM for the space-time analysis while a script was designed in the software R to generate new sizes with three different models of transhumance. From 2005 to 2014, 434 foci were recorded. Many outbreaks occurred in August, September and October. This period corresponds to the small rainy season in the South and the rainy season of the North. The municipality of Parakou was regarded as the source FMD outbreaks in Benin because it hosts one of the largest livestock markets in the country and many rivers. It was the municipality at the highest risk. The other municipalities at risk were Nikki, Pèrèrè and Kalaléas well as Karimama (hosting the national parkW), Kouandé and Toucountouna located nearby Pendjari’s national park. This study revealed that the space-time configuration is real and the main factors of persistence and dissemination of FMD virus were national parks, classified forests and the livestock market of Parakou all located in the North. The variation of the number of cattle due to their transhumance from the North to the South did not influence the zones at risk. Therefore, Northern Benin is probably at high risk of FMD.

关键词： Benin foot-and-mouth disease Zone at Risk Space-Time Analysis Transhumance

Engineering foot-and-mouth disease viruses with increased growth properties and antigenic match for the development of improved vaccine

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Engineering Foot-and-Mouth disease viruses with increased gr...

Immune Potential of a Novel Multiple-epitope Vaccine to FMDV Type Asia 1 in Guinea Pigs and Sheep

中国畜牧兽医学会畜牧兽医生物技术学分会暨中国免疫学会兽医免疫分会第八次学术研讨会

作者： ZHENG Hai-xue~*,GUO Jian-hong,JIN Ye,YANG Fan,HE Ji-jun,ZHANG Ke-san, LIU Xiang-tao~*,CAI Xue-peng (State Key Laboratory of Veterinary Etiological Biology,Key Laboratory of Animal Virology of Ministry of Agricultural, Lanzhou Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Lanzhou 730046,China)

A licensed vaccine is currently not available against serotype A foot-and-mouth disease(FMD) in China since A/WH/CHA/09 was isolated in 2009,partly because it does not replicate well in BHK *** this end,a novel plasmid-based reverse genetics system was employed to construct a chimeric strain by replacing the nearly complete P1 gene in the vaccine strain O/CHA/99 with that in the epidemic stain A/WH/CHA/*** chimeric vius displayed similar growth kinetics with its parental strains and was chosen as the vaccine candidate strain after 12 passages in BHK cells. Subsequently,immunization with the inactivated vaccine was conducted in cattle and humoral immune responses in most of vaccinated cattle were induced at day *** result of virus challenge by A/WH/CHA/09 at day 28 indicates that the group vaccinated by a 10μg dose was fully protected without sub-clinic *** together,our data demonstrate the chimeric vius with O/CHA/99 not only breaks through the bottleneck of propagation in BHK cells compared with A/WH/CHA/09,provides excellent antigenic matching against serotype A FMD,but also is also a potential marker vaccine to distinguish infection and vaccination,which suggests reverse genetics technology is a potential tool to engineer a vaccine candidate for FMD prevention and control.

关键词： foot-and-mouth disease Vaccine Protection Reverse genetics

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Virologica Sinica 2011年第3期26卷 190-197页

作者： Jun-jun Shao Jing-feng Wang Hui-yun Chang Ji-xing Liu College of Veterinary Medicine Gansu Agricultural University Lanzhou 730070 China＂ State key Laboratory of Veterinary Etiological Biology Key Laboratory of Animal Virology of Ministry of AgricultureLanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences Lanzhou 730046 China）

To develop a safe and efficient recombinant subunit vaccine to foot-and-mouth disease virus (FMDV) type Asia 1 in sheep, a tandem repeated multiple-epitope gene consisting of residues 137-160 and 197-211 of the VP1 gene of FMDV was designed and artificially synthesized. The biologically functional molecule, the ovine IgG heavy constant region (oIgG) as a protein carrier was introduced for design of the multiple-epitope recombinant vaccine and recombinant expression plasmids pET-30a-RE and pET-30a-RE-oIgG were successfully constructed. The recombinant proteins, RE and RE-oIgG, were expressed as a formation of inclusion bodies in E. coli. The immune potential of this vaccine regime in guinea pigs and sheep was evaluated. The results showed that IgG could significantly enhance the immune potential of antigenic epitopes. The recombinant protein RE-oIgG could not only elicit the high levels of neutralizing antibodies and lymphocytes proliferation responses in the vaccinated guinea pigs, but confer complete protection in guinea pigs against virus challenge. Although the recombinant protein RE could not confer protection in the vaccinated animals, it could delay the appearance of the clinical signs and reduce the severity of disease. Inspiringly, the titers of anti-FMDV neutralizing antibodies elicited in sheep vaccinated with RE-oIgG was significantly higher than that for the RE vaccination. Therefore, we speculated that this vaccine formulation may be a promising strategy for designing a novel vaccine against FMDV in the future.

关键词： Vaccine foot-and-mouth disease Guinea pigs Epitope

The measurement of pigs median infected dose（PID50） and regulation of live virus challenge dose for FMD vaccines in swine

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The measurement of pigs median infected dose（PID50） and re...