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Variability in fecal metabolome depending on age, PFBS pollutant, and fecal transplantation in zebrafish: A non-invasive diagnosis of health

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Journal of Environmental Sciences 2023年第5期127卷 530-540页

作者： Baili Sun Mengyuan Liu Lizhu Tang Xiangzhen Zhou Chenyan Hu Lianguo Chen State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhan 430072China University of Chinese Academy of Sciences Beijing 100049China School of Chemistry and Environmental Engineering Wuhan Institute of TechnologyWuhan 430072China

To protect the wellbeing of research animals,certain non-invasive measures are in increasing need to facilitate an early diagnosis of health and *** this study,feces specimen was collected from adult zebrafish to profile the metabolome *** in fecal metabolite composition was also distinguished as a result of aging,perfluorobutanesulfonate(PFBS)toxicant,and fecal *** results showed that zebrafish feces was very rich in a diversity of metabolites that belonged to several major classes,including lipid,amino acid,carbohydrate,vitamin,steroid hormone,and *** metabolites had functional implications to multiple physiological activities,which were characterized by the enrichment of digestion,absorption,endocrine,and neurotransmission *** high richness and functional involvement of fecal metabolites pinpointed feces as an abundant source of diagnostic *** comparison between young and aged zebrafish,fundamental modifications of fecal metabolomes were caused by aging progression,centering on the neuroactive ligand-receptor interaction *** of aged zebrafish to PFBS pollutant also significantly disrupted the metabolomic structure in *** special concern were the changes in fecal hormone intermediates after PFBS exposure,which was concordant with the in vivo endocrine disrupting effects of ***,itwas intriguing that transplantation of young zebrafish feces efficientlymitigated the metabolic perturbation of PFBS in aged recipients,highlighting the health benefits of therapeutic strategies based on gut microbiota *** summary,the present study provides preliminary clues to evidence the non-invasive advantage of fecal metabolomics in the early diagnosis and prediction of physiology and toxicology.

关键词： fecal metabolome Aging microbiota Perfluorobutanesulfonate(PFBS) fecal transplantation Non-invasive diagnosis Zebrafish

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Gut microbiota affects the estrus return of sows by regulating the metabolism of sex steroid hormones

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Journal of Animal Science and Biotechnology 2024年第2期15卷 578-599页

作者： Min Liu Jia Zhang Yunyan Zhou Shuqi Xiong Mengqing Zhou Lin Wu Qin Liu Zhe Chen Hui Jiang Jiawen Yang Yuxin Liu Yaxiang Wang Congying Chen Lusheng Huang National Key Laboratory of Swine Genetic Improvement and Germplasm Innovation Jiangxi Agricultural UniversityNanchang 330045China

Background Sex hormones play important roles in the estrus return of post-weaning *** studies have demonstrated a complex and bi-directional regulation between sex hormones and gut ***,the extent to which the gut microbiota affects estrus return of post-weaning sows is largely *** In this study,we first screened 207 fecal samples from well-phenotyped sows by 16S rRNA gene sequencing and identified significant associations between microbes and estrus return of post-weaning *** metagenomic sequencing data from 85 fecal samples,we identified 37 bacterial species that were significantly associated with estrus *** returning sows were characterized by increased abundances of *** and *** and decreased abundances of ***,***,and *** changes in gut microbial composition significantly altered the functional capacity of steroid hormone biosynthesis in the gut *** results were confirmed in a validation *** changes in sex steroid hormones and related compounds were found between normal and non-return sows via metabolome *** integrated analysis of differential bacterial species,metagenome,and fecal metabolome provided evidence that normal return-associated bacterial species *** and Prevotella *** in the degradation of pregnenolone,progesterone,and testosterone,thereby promoting estrogen ***,the microbial metabolites related to sow energy and nutrient supply or metabolic disorders also showed relationships with sow estrus *** An integrated analysis of differentially abundant bacterial species,metagenome,and fecal metabolome revealed the involvement of *** and Prevotella *** sow estrus *** findings provide deep insight into the role of gut microbiota in the estrus return of post-weaning sows and the complex cross-talk between gut microbiota and sex hormones,suggesting that the manipulatio

关键词： Estrus return fecal metabolome Gut microbiota Metagenomics Sex steroid hormones Sow

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Improvement of myocardial injury and gut microbiota disturbance in type 2 diabetic mice by inulin with various degrees of polymerization

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Food Bioscience 2023年第1期51卷 995-1004页

作者： Siqiang Jia Jianpeng Li Bin Yu Mengjie Li Bo Cui State Key Laboratory of Biobased Material and Green Papermaking Qilu University of TechnologyShandong Academy of SciencesJinan250353China School of Food Science and Engineering Qilu University of TechnologyShandong Academy of SciencesJinanShandong250353China

This study is to explore the effects of low-performance inulin(SI,DP10)on myocardial injury in type 2 diabetic mice fed a high-fat diet(HFD)and its underlying *** weeks of supplementation of type 2 diabetic mice with HI significantly improved blood glucose,insulin,and triglyceride levels in comparison with SI(p<0.05).HI had more advantageous effects in ameliorating myocardial injury by suppressing TNF-α,IL-1β,and CK-MB and promoting SDF-1βthan *** to SI,HI more significantly reduced the abundance of Firmicutes from 60.5%to 36.3%in type 2 diabetic mice fed a HFD and increased the abundance of Muribaculum,Blautia and Ruminococcaceae UCG-011 at the genus level(p<0.05).Metabolomics revealed that both SI and HI supplementation regulated tryptophan metabolism,bile acid metabolism,sphingolipid metabolism,and arachidonic acid metabolism,whereas HI supplementation increased prostaglandin h2 compared to *** summary,HI exhibited superior positive regulation of myocardial injury and gut microbiota dysfunction compared to SI.

关键词： Inulin Myocardial injury Type 2 diabetic mice Gut microbiota fecal metabolome

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