Improvement of myocardial injury and gut microbiota disturbance in type 2 diabetic mice by inulin with various degrees of polymerization

作     者：Siqiang Jia Jianpeng Li Bin Yu Mengjie Li Bo Cui 

作者机构：State Key Laboratory of Biobased Material and Green PapermakingQilu University of TechnologyShandong Academy of SciencesJinan250353China School of Food Science and EngineeringQilu University of TechnologyShandong Academy of SciencesJinanShandong250353China 

出 版 物：《Food Bioscience》 (食品生物科学（英文）)

年 卷 期：2023年第51卷第1期

页      面：995-1004页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by the National Key Research&Development Program in China(Grant No.2019YFD1002704) Shandong Major Projects of Independent Innovation(2019JZZY010722) Funds for Innovation Team of Jinan(2018GXRC004) Bohai Sea Granary Science and Technology Demonstration Project(2019BHLC002) Special Funds for Taishan Scholars Project are acknowledged 

主　　题：Inulin Myocardial injury Type 2 diabetic mice Gut microbiota Fecal metabolome 

摘      要：This study is to explore the effects of low-performance inulin(SI,DP10)on myocardial injury in type 2 diabetic mice fed a high-fat diet(HFD)and its underlying *** weeks of supplementation of type 2 diabetic mice with HI significantly improved blood glucose,insulin,and triglyceride levels in comparison with SI(p0.05).HI had more advantageous effects in ameliorating myocardial injury by suppressing TNF-α,IL-1β,and CK-MB and promoting SDF-1βthan *** to SI,HI more significantly reduced the abundance of Firmicutes from 60.5%to 36.3%in type 2 diabetic mice fed a HFD and increased the abundance of Muribaculum,Blautia and Ruminococcaceae UCG-011 at the genus level(p0.05).Metabolomics revealed that both SI and HI supplementation regulated tryptophan metabolism,bile acid metabolism,sphingolipid metabolism,and arachidonic acid metabolism,whereas HI supplementation increased prostaglandin h2 compared to *** summary,HI exhibited superior positive regulation of myocardial injury and gut microbiota dysfunction compared to SI.