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epidemiological survey and genetic characterization of type 3 vaccine-derived poliovirus isolated from a patient with four doses of inactivated polio vaccine in Henan Province,China

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Infectious Diseases of Poverty 2022年第6期11卷 99-100页

作者： Mingyu Zhang Jianhui Yang Yiran Bai Hui Zhu Changshuang Wang Lu Zhang Jin Xu Mingxia Lu Xiaoxiao Zhang Zhanpei Xiao Yating Ma Yan Wang Xiaolei Li Dongyan Wang Shuangli Zhu Dongmei Yan Wenbo Xu Yong Zhang Yanyang Zhang Henan Center for Disease Control and Prevention ZhengzhouHenanPeople’s Republic of China WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingPeople’s Republic of China

Background:Vaccine-derived poliovirus(VDPV)is a potential threat to polio eradication because they can reintroduce into the general population and cause paralytic polio outbreaks,a phenomenon that has recently emerged as a prominent public health concern at the end of global polio *** study aimed to describe the epidemiology and genetic characteristics of the frst VDPV identifed from a patient with acute faccid paralysis(AFP),with four doses of inactivated polio vaccine immunization in Henan Province,China in ***:The patient was diagnosed with type 3 ***,a series of epidemiological approaches was implemented,including a retrospective search of AFP cases,rate of vaccination assessment,study of contacts,and supplementary immunization *** samples were collected,viral isolation was performed,and the viral isolates were characterized using full-length genomic sequencing and bioinformatic ***:Phylogenetic analysis showed that the viral isolates from the patient were diferent from other reported genetic clusters of type 3 VDPV *** were identifed as a Sabin 3/Sabin 1 recombinant VDPV with a crossover site in the P2 *** substitutions,including U→C(472)and C→U(2493),have been identifed,both of which are frequently observed as reversion mutations in neurovirulent type 3 poliovirus.A unique aspect of this case is that the patient had been vaccinated with four doses of inactive polio vaccine,and the serum neutralizing antibody for Sabin types 1 and 3 were 1∶16 and 1∶512,***,the patient was speculated to have been infected with type 3 VDPV,and the virus continued to replicate and be excreted for at least 41 ***:The existence of this kind of virus in human population is a serious risk and poses a severe challenge in maintaining a polio-free status in *** the best of our knowledge,this is the frst report of VDPV identifed in the Henan province of *** results hig

关键词： epidemiological survey Genetic characterization Type 3 vaccine-derived poliovirus Recombination Henan China

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epidemiological survey and Risk Factor Analysis of Recurrent Spontaneous Miscarriages in Infertile Women at Large Infertility Centers

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Chinese Medical Journal 2017年第17期130卷 2056-2062页

作者： Hai-Yan Wang Jie Qiao Xiao-Xi Sun Shu-Yu Wang Xiao-Yan Liang Yun Sun Feng-Hua Liu Reproductive Medical Center Department of Obstetrics and Gynecology Peking University Third Hospital Beijing 100191 China Shanghai Ji Ai Diagnosis and Treatment Center for Genetics and Infertility Shanghai 200011 China Reproductive Medical Center Beijing Obstetrics and Gynecology Hospital Beijing 100006 China Reproductive Medical Center The Sixth Affiliated Hospital Sun Yat-sen University Guangzhou Guangdong 510665 China Reproductive Medical Center Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Shanghai 200011 China Reproductive Medical Center Maternal and Child Health Hospital of Guangdong Province Guangzhou Guangdong 511400 China

Background：A higher frequency of spontaneous miscarriage has been observed in infertile couples,and there is a higher prevalence of infertility among patients with a history of recurrent spontaneous miscarriages （RSMs;〉2 miscarriages）.This study aimed to determine the proportion of infertile patients with RSM and examine risk factors associated in patients with RSM being treated with assisted reproductive ***：This cross-sectional observational study was conducted at six reproductive medicine centers in three cities of *** of 751 patients with at least one spontaneous miscarriage were *** data and etiological factors associated with infertility were compiled and compared between patients with a single spontaneous miscarriage （SSM） and those with ***：Two hundred （26.6%,95% confidence interval [CI]：23.50-29.95%） patients experienced RSMs and 551 （73.4%） had a single *** odds of RSM increased with increasing age （odds ratio [OR] =1.06）,uterine disorders （OR =2.09）,endocrine disorders （OR =2.48）,and immune disorders （OR =2.98）.Higher education level,masters or above,and a pelvic cavity disorder were associated with lower risk of RSM （OR =0.27 and 0.46,respectively）.Late spontaneous miscarriages were more frequent in patients with RSM than in those with a SSM （31.5% vs.14.2%,respectively,P 〈 0.001） and were associated with a history of uterine cavity procedures （OR =2.095） and cervical factors related to infertility （OR =4.136,95% CI：1.012-16.90）.Conclusions：Compared to patients with only a SSM,the conditions of patients with RSM are more *** increase the success rate of assisted reproductive technology,factors including uterus cavity adhesion,cervical relaxation,endocrine disorders,and immune disorders should be treated before assisted reproduction is *** data may provide treatment guidance for infertile patients with a history of RSM.

关键词： Assisted Reproductive Technology epidemiological survey Infertility Recurrent Spontaneous Miscarriage Risk Factor

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epidemiological survey of primary palmar hyperhidrosis in adolescents

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Chinese Medical Journal 2007年第24期120卷 2215-2217页

作者： LI Xu CHEN Rong TU Yuan-rong LIN Min LAI Fan-cai LI Yue-ping CHEN Jian-feng YE Jian-gang Department of Thoracic Surgery First Afliliated Hospital FujianMedical University Fuzhou 350005 China Department of Cardiothoracic Surgery Fuzhou General MilitaryHospital Fuzhou 350002 China School of Public Health Fujian Medical University Fuzhou350004 China

Background Despite recent advances in recognition and treatment of primary palmar hyperhidrosis （PPH）, the epidemiological survey has hardly been conducted. The aim of this study was to investigate the prevalence and epidemiological characteristics of primary PPH among adolescents in three cities of southeast China. Methods Stratified-cluster sampling was carried out and cross-sectional epidemiological survey by questionnaire was applied among 33 000 college and high school students. Results The prevalence rate of PPH was 4.36% affecting both sexes equally. Prevalence rate of severe PPH was 0.27%. The average age of onset was 12.27±2,12 years. The peak age of onset was 6-16 years, accounting for 97.2% of PPH population. Positive family history was found in 17.9% PPH cases. Besides palms, axillae and soles can be also affected. Conclusions PPH affects a larger group of individual than previously reported. More measures should be taken to enhance the recoanition, diaanosis, and treatment of PPH.

关键词： hyperhidrosis prevalence epidemiological survey

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epidemiological-survey-based multidimensional modeling for understanding daily mobility during the COVID-19 pandemic across urban-rural gradient in the Chinese mainland

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Geo-Spatial Information Science 2023年第4期26卷 603-615页

作者： Feng Zhao Zixuan Dai Wenyu Zhang Yiting Shan Cheng Fu Key Laboratory of Geographical Process Analysis&Simulation of Hubei Province Central China Normal UniversityWuhanChina College of Urban and Environmental Sciences Central China Normal UniversityWuhanChina Department of Geography University of ZurichZurichSwitzerland

Human mobility survey data usually suffer from a lack of resources for *** survey records,which are released to the public as a containment measure by local authorities,provide place visitation details validated by the *** study collected and analyzed the epidemiological survey reports published by local governments in the Chinese mainland,between January 2020 and November *** reveal the mobility patterns during the COVID-19 pandemic across the urban-rural gradient in China’s mainland,we derived key mobility indicators from the epidemiological survey data from rural to *** then applied exploratory factor analysis to identify latent factors that affected people’s *** found that the pandemic poses varying impacts across the urban-rural gradient in the Chinese mainland,and the mobility patterns of middle and small cities are more *** results also showed that the pandemic did not enlarge gender gap in people’s mobility,as gender was not a significant driving factor for explaining people’s quantity of out-of-home activities as well as extent of life space,while age group and city levels were ***,we argue that the epidemiological survey data are valuable data sources for daily mobility modeling,especially for relevant studies to understand human mobility patterns during the pandemic.

关键词： Human mobility epidemiological survey exploratory factor analysis gender gap urban-rural gap COVID-19 pandemic

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Identification of tick species and epidemiological survey of Tick-borne theileriosis infection in Qinghai province

Identification of tick species and epidemiological survey of...

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第十一届全国寄生虫学青年工作者学术研讨会

作者： Hu Guangwei Li Jing Shen Yanli Zhao Quanbang Wang Xiaorun Wang Yongzhou Ma Zhanquan Yang Yiqing Cai Jinshan Qinghai Animal Disease Control Center

To investigate the species of ticks and infection rate of Tick-borne theileriosis from March to October 2017 in part of Qinghai *** of 1936 ticks were identified by morphological methods,1936 ticks were detected by PCR with universal primers of Babesia and Theileria parasite,and phylogenetic analysis were conducted based on 18 S r RNA of positive samples;dynamic amount of ticks and infection rate of Theileria parasites in different months in Shandong province were also *** results of tick species identification showed that Haemaphysalis qinghaiensis,Derruacenlor nullalli and Dermacentor *** identified in the presented study,and accounted for 52.09%,35.7% and 12.21%,respectively,Haemaphysalis qinghaiensis predominated in Qinghai province;PCR results showed infection rates of Theileria parasites were17.54%,and infectionrates of Theileria 1 uwenshuni,Theileria uilenberqi and Theileria ovis were 14.49%,2.08%and 0.52%.In addition,the correlativity was observed between dynamic amount of ticks and infection rate of Theileria parsrtes in different months in Qinghai *** results indicated that Heamaphysal is Haemaphysalis qinghaiensis in Qinghai province,infection rates of Theileria 1 uwenshuni,Theileria uilenberqi and Theileria ovis were high,and provided scientific data for prevention and control of theilerios is in Qinghai province.

关键词： tick T.1uwenshuni T.uilenberqi T.ovis epidemiological survey

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牡丹江地区十五年再生障碍性贫血流行病学调查

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牡丹江医学院学报 1988年第2期 86-90页

作者：殷德厚刘长林赵秀兰米丰年郭庆兰曲贵海白俊士邢锋魏哲成宋玉平康真浩周允和朱云亭景华太穆景轩杨柏林金真淑王洪奎赵国良毛桂芹牡丹江医学院血液病研究室牡丹江地区宁安县卫生局牡丹地区穆棱县卫生局牡丹江地区东宁县卫生局牡丹江市一院牡丹江市一院牡丹江地区宁安县医院牡丹地区穆棱县医院牡丹江地区东宁县医院

本院自1970年1月至1984年12月在牡丹江地区五个市县共调查了13,328,339人的再生障碍性贫血的发病情况;二次调查平均患病率3.23/10万,死亡率0.75/10万,10年间平均发病率为1.02/10万;男女之比为1.32:1;发病因素与服药有关者占55.2％、其... 详细信息

本院自1970年1月至1984年12月在牡丹江地区五个市县共调查了13,328,339人的再生障碍性贫血的发病情况;二次调查平均患病率3.23/10万,死亡率0.75/10万,10年间平均发病率为1.02/10万;男女之比为1.32:1;发病因素与服药有关者占55.2％、其中与氯霉素有关者占36.10％;与接触放射线、病毒感染有一定关系。

关键词： Aplastic anemia epidemiological survey

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Quality metrics and outcomes among critically ill patients in China:results of the national clinical quality control indicators for critical care medicine survey 2015-2019

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Chinese Medical Journal 2022年第9期135卷 1064-1075页

作者： Xi Rui Fen Dong Xudong Ma Longxiang Su Guangliang Shan Yanhong Guo Yun Long Dawei Liu Xiang Zhou Department of Critical Care Medicine Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical SciencesBeijing 100029China Institute of Clinical Medical Sciences China-Japan Friendship HospitalBeijing 100029China Department of Medical Administration National Health Commission of the People's Republic of ChinaBeijing 100044China Department of Epidemiology and Biostatistics Institute of Basic Medicine SciencesChinese Academy of Medical Sciences(CAMS)&School of Basic MedicinePeking Union Medical CollegeBeijing 100005China

Background:It is crucial to improve the quality of care provided to ICU patient,therefore a national survey of the medical quality of intensive care units(ICUs)was conducted to analyze adherence to quality metrics and outcomes among critically ill patients in China from 2015 to ***:This was an ICU-level study based on a 15-indicator online survey conducted in *** that ICU care quality may vary between secondary and tertiary hospitals,direct standardization was adopted to compare the rates of ICU quality indicators among provinces/*** analysis was performed to identify potential factors for in-hospital mortality and factors related to ventilator-associated pneumonia(VAP),catheter-related bloodstream infections(CRBSIs),and catheter-associated urinary tract infections(CAUTIs).Results:From the survey,the proportions of structural indicators were 1.83%for the number of ICU inpatients relative to the total number of inpatients,1.44%for ICU bed occupancy relative to the total inpatient bed occupancy,and 51.08%for inpatients with Acute Physiology and Chronic Health Evaluation II scores≥*** proportions of procedural indicators were 74.37%and 76.60%for 3-hour and 6-hour surviving sepsis campaign bundle compliance,respectively,62.93%for microbiology detection,58.24%for deep vein thrombosis prophylaxis,1.49%for unplanned endotracheal extubations,1.99%for extubated inpatients reintubated within 48 hours,6.38%for unplanned transfer to the ICU,and 1.20%for 48-hour ICU *** proportions of outcome indicators were 1.28‰for VAP,3.06‰for CRBSI,3.65‰for CAUTI,and 10.19%for in-hospital *** the indicators varied greatly across provinces and regions,the treatment level of ICUs in China has been stable and improved based on various quality control indicators in the past 5 *** overall mortality rate has dropped from 10.19%to approximately 8%.Conclusions:The quality indicators of medical care in China’s ICUs are hetero

关键词： Medical quality ICU China epidemiological survey

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Outbreak of Mycoplasma pneumoniae at a military academy

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Military Medical Research 2021年第3期8卷 447-449页

作者： Xin Zhang Min-Na Han Jing-Hui Dong Xiao-Xi Li Xian-Yun Hu Zhi Wang En-Qiang Qin Jing Li Jun-Yuan Tan Fu-Sheng Wang Lei Huang Center for Infectious Disease the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Southern Distract Health Service of Chinese PLA General Hospital Beijing 100039China Radiology Department the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Clinical Lab Center the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China Medical Service Department the Fifth Medical Center of Chinese PLA General HospitalBeijing 100039China

In 2019, an outbreak of Mycoplasma pneumoniae(M. pneumoniae) occurred at a military academy in China. The attack rate(10.08%, 60/595) was significantly different among the units. High-intensity training and crowded environments to which cadets are exposed are the high risk factors for the outbreak of M. pneumoniae. In-time prevention and control measures effectively controlled the spread of the epidemic.

关键词： Mycoplasma pneumoniae epidemiological survey Disease control and prevention

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Activities of daily living and lesion position among multiple sclerosis patients by Bayes network

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Neural Regeneration Research 2013年第14期8卷 1327-1336页

作者： Zhifang Pan Hongtao Lu Qi Cheng Department of Computer Science and Engineering Shanghai Jiao Tong University School of Information & Engineering Wenzhou Medical College School of Public Health Shanghai Jiao Tong University Department of Neurology Ruijin HospitalShanghai Jiao Tong University School of Medicine

Magnetic resonance imaging is a highly sensitive approach for diagnosis of multiple sclerosis, and T2-weighted images can reveal lesions in the cerebral white matter, gray matter, and spinal cord. However, the lesions have a poor correlation with measurable clinical disability. In this study, we performed a large-scale epidemiological survey of 238 patients with multiple sclerosis in eleven districts by network member hospitals in Shanghai, China within 1 year. The involved patients were scanned for position and size of lesions by MRI. Results showed that lesions in the cerebrum, spina cord, or supratentorial position had an impact on the activities of daily living in multiple sclerosis patients, as assessed by the Bayes network. On the other hand, brainstem lesions were very unlikely to influence the activities of daily living, and were not associated with the position of lesion, patient＇s gender, and patient＇s living place.

关键词： neural regeneration neurodegenerative diseases multiple sclerosis magnetic resonance imaging Bayes network activities of daily living epidemiological survey grants-supported paper neuroregeneration

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Allergic Constitution Theory of Chinese Medicine and its Assessment Criterion and Related Studies

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Chinese Journal of Integrative Medicine 2015年第9期21卷 716-720页

作者：王济王停李英帅李玲孺郑燕飞王琦 Center for Studies in Constitution Research of Traditional Chinese Medicine Basic Medical SchoolBeijing University of Chinese Medicine

Constitution factor plays an important role in the occurrence, development, and transformation of diseases. The occurrence of allergic diseases is mainly caused by the disorganized physiological function and suitability regulation of patients, except for their exposure to outside allergens. Moreover, it represents susceptibility and hypersensitivity to allergens. The currant study expresses the concept of allergic constitution from the perspective of Chinese medicine （CM） and presents the criterion of allergic constitution. In addition, the distribution of allergic constitution in population, its factors, and its relation to health-related quality of life （HRQOL） were investigated. The HRQOL scores of allergic constitution were found to be lower than those of the Pinghe constitution. After making a study on the gene expression profile of allergic constitution, the characteristics of up-regulated or down-regulated genes were found. Finally, CM drug was researched and developed to improve allergic constitution. Based on clinical trials and animal experiments, CM is found to have good regulatory effects on allergic constitution.

关键词： allergic constitution criterion epidemiological survey gene expression prevention and cure

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