Epidemiological survey and genetic characterization of type 3 vaccine-derived poliovirus isolated from a patient with four doses of inactivated polio vaccine in Henan Province,China

作     者：Mingyu Zhang Jianhui Yang Yiran Bai Hui Zhu Changshuang Wang Lu Zhang Jin Xu Mingxia Lu Xiaoxiao Zhang Zhanpei Xiao Yating Ma Yan Wang Xiaolei Li Dongyan Wang Shuangli Zhu Dongmei Yan Wenbo Xu Yong Zhang Yanyang Zhang 

作者机构：Henan Center for Disease Control and PreventionZhengzhouHenanPeople’s Republic of China WHO WPRO Regional Polio Reference Laboratory and National Health Commission Key Laboratory for BiosafetyNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingPeople’s Republic of China 

出 版 物：《Infectious Diseases of Poverty》 (贫困所致传染病（英文）)

年 卷 期：2022年第11卷第6期

页      面：99-100页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100705[医学-微生物与生化药学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：Henan Province Key R&D and Promotion, (182102310226) Henan Province Medical Science and Technology Joint construction Project, (LHGJ20190711) Natural Science Foundation of Beijing Municipality, (L192014) Natural Science Foundation of Beijing Municipality National Key Research and Development Program of China, NKRDPC, (2021YFC2302003) National Key Research and Development Program of China, NKRDPC 

主　　题：Epidemiological Survey Genetic characterization Type 3 vaccine-derived poliovirus Recombination Henan China 

摘      要：Background:Vaccine-derived poliovirus(VDPV)is a potential threat to polio eradication because they can reintroduce into the general population and cause paralytic polio outbreaks,a phenomenon that has recently emerged as a prominent public health concern at the end of global polio *** study aimed to describe the epidemiology and genetic characteristics of the frst VDPV identifed from a patient with acute faccid paralysis(AFP),with four doses of inactivated polio vaccine immunization in Henan Province,China in ***:The patient was diagnosed with type 3 ***,a series of epidemiological approaches was implemented,including a retrospective search of AFP cases,rate of vaccination assessment,study of contacts,and supplementary immunization *** samples were collected,viral isolation was performed,and the viral isolates were characterized using full-length genomic sequencing and bioinformatic ***:Phylogenetic analysis showed that the viral isolates from the patient were diferent from other reported genetic clusters of type 3 VDPV *** were identifed as a Sabin 3/Sabin 1 recombinant VDPV with a crossover site in the P2 *** substitutions,including U→C(472)and C→U(2493),have been identifed,both of which are frequently observed as reversion mutations in neurovirulent type 3 poliovirus.A unique aspect of this case is that the patient had been vaccinated with four doses of inactive polio vaccine,and the serum neutralizing antibody for Sabin types 1 and 3 were 1∶16 and 1∶512,***,the patient was speculated to have been infected with type 3 VDPV,and the virus continued to replicate and be excreted for at least 41 ***:The existence of this kind of virus in human population is a serious risk and poses a severe challenge in maintaining a polio-free status in *** the best of our knowledge,this is the frst report of VDPV identifed in the Henan province of *** results hig