检索结果-南通市图书馆

Impacts of prenatal nutrition on animal production and performance： a focus on growth and metabolic and endocrine function in sheep

引用

Journal of Animal Science and Biotechnology 2018年第1期9卷 10-23页

作者： Prabhat Khanal Mette Olaf Nielsen Department of Veterinary and Animal Sciences Faculty of Health and Medical SciencesUniversity of Copenhagen Gronnegardsvey 31st floorDK-1870 Frederiksberg CDenmark Department of Nutrition Faculty of MedicineTransgenic Animal and Lipid StorageNorwegian Transgenic Centre(NTS)University of OsloOsloNotway

The concept of foetal programming（FP） originated from human epidemiological studies, where foetal life nutrition was linked to health and disease status later in life. Since the proposal of this phenomenon, it has been evaluated in various animal models to gain further insights into the mechanisms underlying the foetal origins of health and disease in humans. In FP research, the sheep has been quite extensively used as a model for humans. In this paper we will review findings mainly from our Copenhagen sheep model, on the implications of late gestation malnutrition for growth, development, and metabolic and endocrine functions later in life, and discuss how these implications may depend on the diet fed to the animal in early postnatal life. Our results have indicated that negative implications of foetal malnutrition, both as a result of overnutrition and, particularly, late gestation undernutrition, can impair a wide range of endocrine functions regulating growth and presumably also reproductive traits. These implications are not readily observable early in postnatal life, but are increasingly manifested as the animal approaches adulthood. No intervention or cure is known that can reverse this programming in postnatal life. Our findings suggest that close to normal growth and slaughter results can be obtained at least until puberty in animals which have undergone adverse programming in foetal life, but manifestation of programming effects becomes increasingly evident in adult *** to the risk of transfer of the adverse programming effects to future generations, it is therefore recommended that animals that are suspected to have undergone adverse FP are not used for reproduction. Unfortunately, no reliable biomarkers have as yet been identified that allow accurate identification of adversely programmed offspring at birth,except for very low or high birth weights, and, in pigs, characteristic changes in head shape（dolphin head）. Future efforts should be therefo

关键词： Adipose tissue endocrine function Foetal programming Metabolic function Sheep

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Newly discovered endocrine functions of the liver

引用

World Journal of Hepatology 2021年第11期13卷 1611-1628页

作者： Jane Rhyu Run Yu Division of Endocrinology Diabetesand MetabolismUCLA David Geffen School of MedicineLos AngelesCA 90095United States

The liver,the largest solid visceral organ of the body,has numerous endocrine functions,such as direct hormone and hepatokine production,hormone metabolism,synthesis of binding proteins,and processing and redistribution of metabolic *** the last 10 years,many new endocrine functions of the liver have been *** in the classical endocrine functions include delineation of mechanisms of liver production of endocrine hormones[including 25-hydroxyvitamin D,insulin-like growth factor 1(IGF-1),and angiotensinogen],hepatic metabolism of hormones(including thyroid hormones,glucagon-like peptide-1,and steroid hormones),and actions of specific binding proteins to glucocorticoids,sex steroids,and thyroid *** studies have furthered insight into cirrhosis-associated endocrinopathies,such as hypogonadism,osteoporosis,IGF-1 deficiency,vitamin D deficiency,alterations in glucose and lipid homeostasis,and controversially relative adrenal *** novel endocrine functions of the liver have also been unraveled,elucidating the liver’s key negative feedback regulatory role in the pancreaticαcell-liver axis,which regulates pancreaticαcell mass,glucagon secretion,and circulating amino acid *** and other hepatokines,such as fetuin-A and fibroblast growth factor 21,have also been discovered to play important endocrine roles in modulating insulin sensitivity,lipid metabolism,and body *** is expected that more endocrine functions of the liver will be revealed in the near future.

关键词： Liver endocrine function Hormone Amino acids Hepatokine Fibroblast growth factor 21

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pancreatic necrosis and severity are independent risk factors for pancreatic endocrine insufficiency after acute pancreatitis: A long-term follow-up study

引用

World Journal of Gastroenterology 2020年第23期26卷 3260-3270页

作者： Bing-Jun Yu Nian-Shuang Li Wen-Hua He Cong He Jian-Hua Wan Yin Zhu Nong-Hua Lu Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUND Pancreatic endocrine insufficiency after acute pancreatitis(AP) has drawn increasing attention in recent *** To assess the impact of risk factors on the development of pancreatic endocrine insufficiency after *** This retrospective observational long-term follow-up study was conducted in a tertiary hospital. endocrine function was evaluated by the oral glucose tolerance test. The data, including age, sex, body mass index, APACHE II score, history of smoking and drinking, organ failure, pancreatic necrosis, debridement of necrosis(minimally invasive and/or open surgery), and time interval, were collected from the record *** A total of 361 patients were included in the study from January 1, 2012 to December 30, 2018. A total of 150(41.6%) patients were diagnosed with dysglycemia(including diabetes mellitus and impaired glucose tolerance), while211(58.4%) patients had normal endocrine function. The time intervals(mo) of the above two groups were 18.73 ± 19.10 mo and 31.53 ± 27.27 mo, respectively(P= 0.001). The morbidity rates of pancreatic endocrine insufficiency were 46.7%,28.0%, and 25.3%, respectively, in the groups with different follow-up times. The risk factors for pancreatic endocrine insufficiency after AP were severity(odds ratio [OR] = 3.489;95% confidence interval [CI]: 1.501-8.111;P = 0.004) and pancreatic necrosis(OR = 4.152;95%CI: 2.580-6.684;P = 0.001).CONCLUSION Pancreatic necrosis and severity are independent risk factors for pancreatic endocrine insufficiency after AP. The area of pancreatic necrosis can affect pancreatic endocrine function.

关键词： Acute pancreatitis Pancreatic necrosis Diabetes Pancreatic necrosis Pancreatic necrosis debridement endocrine function

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Central pancreatectomy for benign or low-grade malignant pancreatic tumors in the neck and body of the pancreas

引用

World Journal of Gastrointestinal Surgery 2022年第9期14卷 896-903页

作者： Yi-Wen Chen Jian Xu Xiang Li Wei Chen Shun-Liang Gao Yan Shen Min Zhang Jian Wu Ri-Sheng Que Jun Yu Ting-Bo Liang Xue-Li Bai Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Pancreatic Disease Zhejiang Provincial Key LaboratoryHangzhou 310000Zhejiang ProvinceChina The Study of Pancreatic Disease Zhejiang Provincial Innovation CenterHangzhou 310000Zhejiang ProvinceChina The Study of Hepatobiliary&Pancreatic Diseases Zhejiang Provincial Clinical Research CenterHangzhou 310003Zhejiang ProvinceChina Cancer Center Zhejiang UniversityHangzhou 310058Zhejiang ProvinceChina

BACKGROUND For tumors in the neck and body of the pancreas,distal pancreatectomy(DP)has been the standard surgical procedure for the last few decades and central pancreatectomy(CP)is an alternative surgical *** CP better preserves remnant pancreatic endocrine and exocrine functions after surgery remains a subject of *** To evaluate the safety and efficacy of CP compared with DP for benign or lowgrade malignant pancreatic tumors in the neck and body of the *** This retrospective study enrolled 296 patients who underwent CP or DP for benign and low-malignant neoplasms at the same hospital between January 2016 and March *** outcomes and long-term morbidity of endocrine/exocrine function were prospectively *** No significant difference was observed in overall morbidity or clinically relevant postoperative pancreatic fistula between the two groups(P=0.055).Delayed gastric emptying occurred more frequently in the CP group than in the DP group(29.4%vs 15.3%;Pendocrine function deficiency after surgery(Pendocrine and exocrine ***,CP might be a better option for treating benign or low-grade malignant neoplasms in suitable patients.

关键词： Central pancreatectomy Distal pancreatectomy endocrine function Exocrine function Morbidity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone functions as a novel endocrine organ in energy metabolism

引用

Chinese Medical Journal 2012年第22期125卷 4117-4121页

作者： CHEN Xiang TIAN Hao-ming PEI Fu-xing YU Xi-jie Sichuan Univ Lab Endocrinol & Metab W China Hosp Chengdu 610041 Sichuan Peoples R China Sichuan Univ Dept Endocrinol W China Hosp Chengdu 610041 Sichuan Peoples R China Sichuan Univ Dept Orthoped W China Hosp Chengdu 610041 Sichuan Peoples R China

The classic endocrine concept is a matter of dispute. The term ＂endocrine＂ denotes internal secretion of bioactive substances, in contrast to ＂exocrine,＂ which denotes secretion outside the body. Traditionally, the endocrine organs refer to classic organs, such as the thyroid, gonadal, or adrenal glands; however, some non-classic endocrine organs have been shown to have endocrine functions. For example,

关键词： bone osteocalcin endocrine function energy metabolism feedback loop

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Spleen:A new role ffoorr an old player?

引用

World Journal of Gastroenterology 2011年第33期17卷 3776-3784页

作者： Giovanni Tarantino Silvia Savastano Domenico Capone Annamaria Colao Department of Clinical and Experimental Medicine Federico Ⅱ University Medical School of NaplesVia S.Pansini 580131 NaplesItaly Department of Molecular and Clinical Endocrinology and Oncology Division of EndocrinologyFederico Ⅱ University Medical School of NaplesVia S.Pansini 580131 NaplesItaly Department of Neurosciences Unit of Clinical PharmacologyFederico Ⅱ University Medical School of Naples80131 NaplesItaly

The spleen could be considered a neglected *** date,it has been deemed an ancillary organ in portal hypertension or an organ localization in lymphoproliferative diseases,even though it has had significant attention in infectious diseases for some ***,it is thought to be central in regulating the immune system,a metabolic asset and involved in endocrine function with regard to nonalcoholic fatty liver *** main mechanisms involved in this complex network will be critically discussed in this article.

关键词： endocrine function Immune system Metabolic asset Nonalcoholic fatty liver disease Spleen

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Resistin-binding peptide antagonizes role of resistin on white adipose tissue

引用

Acta Pharmacologica Sinica 2007年第2期28卷 221-226页

作者： Nan GU~(2,3,4) Shu-ping HAN~(2,4) Li FEI~3 Xiao-qin PAN~3 Mei GUO~3 Rong-hua CHEN~3 Xi-rong GUO~(2,3,5)2 Department of Pediatrics,Nanjing Maternal and Child Health Hospital of Nanjing Medical University,Nanjing 210029,China 3 Pediatric Research Institute of Nanjing Medical University,Nanjing 210029,China DepartmentofPediatrics NanjingMaternalandChildHealthHospitalofNanjingMedicalUniversityNanjing210029China PediatricResearchInstituteofNanjingMedicalUniversity Nanjing210029China

Aim:To investigate the direct effects of resistin and resistin-binding peptide（RBP）on lipid metabolism and endocrine function in adipose ***:Ratwhite adipose tissue was cultured in vitro and incubated for 24 h with 30 ng/mLrecombinant rat resistin protein（rResistin）or combined with RBP of varyingconcentrations(1×1-12mol/L,1×10-10mol/L,1×10-8mol/L).Free fatty acids（FFA）released into medium was measured by a colorimetric *** levels of proteinsecretion and mRNA expression of TNF-α and adiponectin were detected by ELISAkit and RT-PCR ***:The levels of FFA released into mediumwere significantly increased after 24 h of exposure to rResistin,but significantlydecreased after RBP was applied,although there was no difference between the *** protein level and gene expression of TNF-αin adipose tissuewere significantly increased after 24 h of exposure to rResistin,but only obviouslydecreased after incubated with 1×10-8mol/L *** levels of protein secretionand mRNA expression of adiponectin in adipose tissue were significantly de-creased after 24 h of exposure to rResistin,but increased after incubated with RBPwith the higher ***:RBP can effectively antagonize therole of resistin on the lipid metabolism and endocrine function of adipose tissue.

关键词： resistin resistin-binding peptide white adipose tissue lipid metabolism endocrine function

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：