Central pancreatectomy for benign or low-grade malignant pancreatic tumors in the neck and body of the pancreas

作     者：Yi-Wen Chen Jian Xu Xiang Li Wei Chen Shun-Liang Gao Yan Shen Min Zhang Jian Wu Ri-Sheng Que Jun Yu Ting-Bo Liang Xue-Li Bai 

作者机构：Department of Hepatobiliary and Pancreatic SurgeryThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Pancreatic DiseaseZhejiang Provincial Key LaboratoryHangzhou 310000Zhejiang ProvinceChina The Study of Pancreatic DiseaseZhejiang Provincial Innovation CenterHangzhou 310000Zhejiang ProvinceChina The Study of Hepatobiliary&Pancreatic DiseasesZhejiang Provincial Clinical Research CenterHangzhou 310003Zhejiang ProvinceChina Cancer CenterZhejiang UniversityHangzhou 310058Zhejiang ProvinceChina 

出 版 物：《World Journal of Gastrointestinal Surgery》 (世界胃肠外科杂志（英文版）（电子版）)

年 卷 期：2022年第14卷第9期

页      面：896-903页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the National Natural Science Foundation of China,No.82172859,81801566,and 82071867 the National Key Research and Development Program of China,No.2019YFC1316000 

主　　题：Central pancreatectomy Distal pancreatectomy Endocrine function Exocrine function Morbidity 

摘      要：BACKGROUND For tumors in the neck and body of the pancreas,distal pancreatectomy(DP)has been the standard surgical procedure for the last few decades and central pancreatectomy(CP)is an alternative surgical *** CP better preserves remnant pancreatic endocrine and exocrine functions after surgery remains a subject of *** To evaluate the safety and efficacy of CP compared with DP for benign or lowgrade malignant pancreatic tumors in the neck and body of the *** This retrospective study enrolled 296 patients who underwent CP or DP for benign and low-malignant neoplasms at the same hospital between January 2016 and March *** outcomes and long-term morbidity of endocrine/exocrine function were prospectively *** No significant difference was observed in overall morbidity or clinically relevant postoperative pancreatic fistula between the two groups(P=0.055).Delayed gastric emptying occurred more frequently in the CP group than in the DP group(29.4%vs 15.3%;P0.005).None of the patients in the CP group had new-onset or aggravated distal metastasis,whereas 40 patients in the DP group had endocrine function deficiency after surgery(P0.05).There was no significant difference in the incidence of diarrhea immediately after surgery,but at postoperative 12 mo,a significantly higher number of patients had diarrhea in the DP group than in the CP group(0%vs 9.5%;P0.05).CONCLUSION CP is a generally safe procedure and is better than DP in preserving long-term pancreatic endocrine and exocrine ***,CP might be a better option for treating benign or low-grade malignant neoplasms in suitable patients.