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Genes & Diseases 2024年第5期11卷 236-251页

作者： Gui-e Xu Xuan Zhao Guoping Li Priyanka Gokulnath Lijun Wang Junjie Xiao Institute of Geriatrics(Shanghai University) Affiliated Nantong Hospital of Shanghai University(The Sixth People’s Hospital of Nantong)and School of Life SciencesShanghai UniversityNantongJiangsu 226011China Cardiac Regeneration and Ageing Lab Institute of Cardiovascular SciencesShanghai Engineering Research Center of Organ RepairSchool of Life ScienceShanghai UniversityShanghai 200444China Cardiovascular Division of the Massachusetts General Hospital and Harvard Medical School BostonMA 02114USA

RNA N^(6)-methyladenosine(m^(6)A)methylation is the most abundant and conserved RNA modification in *** participates in the regulation of RNA metabolism and various pathophysiological ***-coding RNAs(ncRNAs)are defined as small or long transcripts which do not encode proteins and display numerous biological regulatory *** to mRNAs,m^(6)A deposition is observed in *** RNA m^(6)A modifications on ncRNAs is of great importance specifically to deepen our understanding of their biological roles and clinical *** this review,we summarized the recent research findings regarding the mutual regulation between RNA m^(6)A modification and ncRNAs(with a specific focus on microRNAs,long non-coding RNAs,and circular RNAs)and their *** also discussed the challenges of m^(6)A-containing ncRNAs and RNA m^(6)A as therapeutic targets in human diseases and their future perspective in translational roles.

关键词： Circular RNA epigenetic regulation Long non-coding RNA MicroRNA Non-coding RNA RNA m^(6)A modification

epigenetic regulation by polycomb group complexes:focus on roles of CBX proteins

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2014年第5期15卷 412-428页

作者： Rong-gang MA Yang ZHANG Ting-ting SUN Bo CHENG School of Life Sciences Lanzhou University

Polycomb group （PCG） complexes are epigenetic regulatory complexes that conduct transcriptional repression of target genes via modifying the chromatin. The two best characterized forms of PCG complexes, polycomb repressive complexes 1 and 2 （PRC1 and PRC2）, are required for maintaining the sternness of embryonic stem cells and many types of adult stem cells. The spectra of target genes for PRCs are dynamically changing with cell differentiation, which is essential for proper decisions on cell fate during developmental processes, Chromobox （CBX） family proteins are canonical components in PRC1, responsible for targeting PRC1 to the chromatin. Recent studies highlight the function specifications among CBX family members in undifferentiated and differentiated stem cells, which reveal the interplay between compositional diversity and functional specificity of PRCI. In this review, we summarize the current knowledge about targeting and functional mechanisms of PRCs, emphasizing the recent breakthroughs related to CBX proteins under a number of physiological and pathological conditions.

关键词： Polycomb Polycomb repressive complex 1 (PRC1) Chromobox (CBX) protein epigenetic regulation Cancer

epigenetic regulation of adipocyte differentiation and adipogenesis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第10期11卷 784-791页

作者： Hong-xing LI Lei XIAO Cheng WANG Jia-li GAO Yong-gong ZHAI Key Laboratory for Cell Proliferation and regulation Biology of Ministry of Education College of Life Sciences Beo'ing Normal University Beijing 100875 China Reproductive Medicine Research Center the First Hospital of Lanzhou University Lanzhou 730000 China Beijing Key Laboratory of Engineered Drug and Biotechnology College of Life Sciences Beijing Normal University Beijing 100875 China Biomedicine Research Institute College of Life Sciences Beijing Normal University Beijing 100875 China Feed Research Institute Chinese Academy of Agricultural Sciences Beijing 100081 China

It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes:determination and *** the past decade,many factors associated with epigenetic signals have been proved to be pivotal for the appropriate timing of adipogenesis progression.A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation,histone acetylation and methylation,and nucleosome rearrangement,that act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis during *** this review,we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.

关键词： epigenetic regulation Histone modification DNA methylation Differentiation Adipogenesis

epigenetic regulation of B cells and its role in autoimmune pathogenesis

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Cellular & Molecular Immunology 2022年第11期19卷 1215-1234页

作者： Fan Xiao Ke Rui Xiaofei Shi Haijing Wu Xiaoyan Cai Kathy O.Lui Qianjin Lu Esteban Ballestar Jie Tian Hejian Zou Liwei Lu Department of Pathology Shenzhen Institute of Research and Innovation and Shenzhen HospitalThe University of Hong KongHong KongChongqing International Institute for ImmunologyChongqingChina Institute of Medical Immunology Affiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Rheumatology and Immunology The First Affiliated Hospital and School of MedicineHenan University of Science and TechnologyLuoyangChina Department of Dermatology Second Xiangya HospitalCentral South UniversityHunan Key Laboratory of Medical EpigenomicsChangshaHunanChina Department of Rheumatology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina Department of Chemical Pathology Faculty of MedicinePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina epigenetics and Immune Disease Group Josep Carreras Research InstituteBadalona08916 BarcelonaSpain epigenetics in Inflammatory and Metabolic Diseases Laboratory Health Science CenterEast China Normal UniversityShanghaiChina Department of Rheumatology Huashan HospitalFudan UniversityShanghaiChina Centre for Oncology and Immunology Hong Kong Science ParkHong KongChina

B cells play a pivotal role in the pathogenesis of autoimmune *** previous studies have shown many genetic polymorphisms associated with B-cell activation in patients with various autoimmune disorders,progress in epigenetic research has revealed new mechanisms leading to B-cell *** mechanisms,including those involving histone modifications,DNA methylation,and noncoding RNAs,regulate B-cell responses,and their dysregulation can contribute to the pathogenesis of autoimmune *** with autoimmune diseases show epigenetic alterations that lead to the initiation and perpetuation of autoimmune ***,many clinical and animal model studies have shown the promising potential of epigenetic therapies for *** this review,we present an up-to-date overview of epigenetic mechanisms with a focus on their roles in regulating functional B-cell ***,we discuss epigenetic dysregulation in B cells and highlight its contribution to the development of autoimmune *** on clinical and preclinical evidence,we discuss novel epigenetic biomarkers and therapies for patients with autoimmune disorders.

关键词： B cells epigenetic regulation Autoimmune disease Biomarker Therapy

epigenetic regulation of N-hydroxypipecolic acid biosynthesis by the AIPP3-PHD2-CPL2 complex

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Journal of Integrative Plant Biology 2023年第12期65卷 2660-2671页

作者： Jiameng Lan Siyu Chen Joana Pico Kevin Ao Shitou Xia Shucai Wang Xin Li Simone D.Castellarin Yuelin Zhang Department of Botany University of British ColumbiaVancouverV6T 1Z4 Canada Laboratory of Plant Molecular Genetics&Crop Gene Editing School of Life SciencesLinyi UniversityLinyi276005 China Wine Research Centre Faculty of Land and Food SystemsUniversity of British ColumbiaVancouver V6T 1Z4Canada Michael Smith Laboratories University of BritishColumbiaVancouverV6T1Z4Canada Hunan Provincial Key Laboratory of Phytohormones Hunan Agricultural UniversityChangsha 410125China College of Life Science Sichuan UniversityChengdu 610064China

N-Hydroxypipecolic acid(NHP)is a signaling molecule crucial for systemic acquired resistance(SAR),a systemic immune response in plants that provides long-lasting and broad-spectrum protection against secondary pathogen *** identify negative regulators of NHP biosynthesis,we performed a forward genetic screen to search for mutants with elevated expression of the NHP biosynthesis gene FLAVIN-DEPENDENT MONOOXYGENASE 1(FMO1).Analysis of two constitutive expression of FMO1(cef)and one induced expression of FMO1(ief)mutants revealed that the AIPP3–PHD2–CPL2 protein complex,which is involved in the recognition of the histone modification H3K27me3 and transcriptional repression,contributes to the negative regulation of FMO1 expression and NHP *** study suggests that epigenetic regulation plays a crucial role in controlling FMO1 expression and NHP levels in plants.

关键词： plant immunity SAR epigenetic regulation NHP FMO1 H3K27me3 transcriptional repression AIPP3 PHD2 CPL2

epigenetic regulation of dental pulp stem cells and its potential in regenerative endodontics

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World Journal of Stem Cells 2021年第11期13卷 1647-1666页

作者： Ying Liu Lu Gan Di-Xin Cui Si-Han Yu Yue Pan Li-Wei Zheng Mian Wan State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Pediatric DentistryWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina State Key Laboratory of Oral Diseases National Clinical Research Center for Oral DiseasesDepartment of Cariology and EndodonticsWest China Hospital of StomatologySichuan UniversityChengdu 610041Sichuan ProvinceChina

Regenerative endodontics(RE)therapy means physiologically replacing damaged pulp tissue and regaining functional dentin–pulp *** clinical RE procedures recruit endogenous stem cells from the apical papilla,periodontal tissue,bone marrow and peripheral blood,with or without application of scaffolds and growth factors in the root canal space,resulting in cementum-like and bone-like tissue *** the involvement of dental pulp stem cells(DPSCs),it is unlikely that functional pulp regeneration can be achieved,even though acceptable repair can be ***,due to their specific odontogenic potential,high proliferation,neurovascular property,and easy accessibility,are considered as the most eligible cell source for dentin–pulp *** regenerative potential of DPSCs has been demonstrated by recent clinical *** transplantation following pulpectomy has successfully reconstructed neurovascularized pulp that simulates the physiological structure of natural *** self-renewal,proliferation,and odontogenic differentiation of DPSCs are under the control of a cascade of transcription *** recent decades,epigenetic modulations implicating histone modifications,DNA methylation,and noncoding(nc)RNAs have manifested as a new layer of gene *** modulations exhibit a profound effect on the cellular activities of *** this review,we offer an overview about epigenetic regulation of the fate of DPSCs;in particular,on the proliferation,odontogenic differentiation,angiogenesis,and *** emphasize recent discoveries of epigenetic molecules that can alter DPSC status and promote pulp regeneration through manipulation over epigenetic profiles.

关键词： Dental pulp stem cells Regenerative endodontics epigenetic regulation Noncoding RNAs Histone deacetylase inhibitor DNA methyltransferase inhibitor

epigenetic regulation of covalently closed circular DNA minichromosome in hepatitis B virus infection

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Biophysics Reports 2020年第4期6卷 115-126页

作者： Zhaoning Wang Weiwei Wang Lanfeng Wang School of Life Sciences Shanghai University The Center for Microbes Development and Health CAS Key Laboratory of Molecular Virology & ImmunologyInstitut Pasteur of Shanghai Chinese Academy of Sciences

Hepatitis B is caused by hepatitis B virus(HBV), and persistent HBV infection is a global public health problem, with 257 million people as HBV chronic carriers. Viral covalently closed circular DNA(cccDNA) is a key factor to establish persistent infection in infected hepatocytes. Current antiviral therapies have no direct impact on pre-existing cccDNA reservoir, which can be assembled into minichromosome by hijacking host factors. Understanding the mechanisms of epigenetic regulation in cccDNA minichromosome is crucial to develop new therapy on cccDNA, an attractive target for HBV cure. This review summarizes the current advances in epigenetic regulation of cccDNA minichromosome, which might provide clues to novel druggable targets to cure hepatitis B by either silencing or eliminating cccDNA reservoir.

关键词： HBV cccDNA Minichromosome epigenetic regulation

Genome-wide distribution and functions of the AAE complex in epigenetic regulation in Arabidopsis

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Journal of Integrative Plant Biology 2021年第4期63卷 707-722页

作者： Yi-Zhe Zhang Juncheng Lin Zhizhong Ren Chun-Xiang Chen Daisuke Miki Si-Si Xie Jian Zhang Ya-Nan Chang Jing Jiang Jun Yan Qingshun Q.Li Jian-Kang Zhu Cheng-Guo Duan Shanghai Center for Plant Stress Biology and CAS Center of Excellence for Molecular Plant Sciences Chinese Academy of SciencesShanghai 201602China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of the Ministry of Education for Coastal and Wetland Ecosystems College of the Environment and EcologyXiamen UniversityXiamen 361102China State Key Laboratory of Crop Stress Adaptation and Improvement School of Life SciencesHenan UniversityKaifeng 475004China School of Life Sciences East China Normal UniversityShanghai 200241China Graduate College of Biomedical Sciences Western University of Health SciencesPomona 91766USA Department of Horticulture and Landscape Architecture Purdue UniversityWest Lafayette 47907USA

Heterochromatin is widespread in eukaryotic genomes and has diverse impacts depending on its genomic *** studies have shown that a protein complex,the ASI1-AIPP1-EDM2(AAE)complex,participates in polyadenylation regulation of several intronic heterochromatin-containing ***,the genome-wide functions of AAE are still ***,we show that the ASI1 and EDM2 mostly target the common genomic regions on a genome-wide level and preferentially interacts with genetic ***(poly(A)sequencing reveals that AAE complex has a substantial influence on poly(A)site usage of heterochromatin-containing genes,includingnotonlyintronicheterochromatincontaining genes but also the genes showing overlap with ***,AAE is also involved in the alternative splicing regulation of a number of heterochromatin-overlapping genes,such as the disease resistance gene *** provided evidence that genic heterochromatin is indispensable for the recruitment of AAE in polyadenylation and splicing *** addition to conferring RNA processing regulation at genic heterochromatin-containing genes,AAE also targets some transposable elements(TEs)outside of genes(including TEs sandwiched by genes and island TEs)for epigenetic *** results reveal new functions of AAE in RNA processing and epigenetic silencing,and thus representimportantadvancesinepigenetic regulation.

关键词： alternative polyadenylation alternative splicing epigenetic regulation heterochromatin transcription

Recent advances in understanding of the epigenetic regulation of plant regeneration

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aBIOTECH 2023年第1期4卷 31-46页

作者： Xuemei Liu Kehui Zhu Jun Xiao Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China CAS-JIC Centre of Excellence for Plant and Microbial Science(CEPAMS) Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

Ever since the concept of"plant cell totipotency"was first proposed in the early twentieth century,plant regeneration has been a major focus of ***-mediated organogenesis and genetic transformation are important topics in both basic research and modern *** studies in the model plant Arabidopsis thaliana and other species have expanded our understanding of the molecular regulation of plant *** hierarchy of transcriptional regulation driven by phytohormone signaling during regeneration is associated with changes in chromatin dynamics and DNA ***,we summarize how various aspects of epigenetic regulation,including histone modifications and variants,chromatin accessibility dynamics,DNA methylation,and microRNAs,modulate plant *** the mechanisms of epigenetic regulation are conserved in many plants,research in this field has potential applications in boosting crop breeding,especially if coupled with emerging single-cell omics technologies.

关键词： Plant regeneration epigenetic regulation Arabidopsis Crop breeding

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene

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Protein & Cell 2010年第1期1卷 22-32页

作者： Jiyue Zhu Yuanjun Zhao Shuwen Wang Department of Cellular and Molecular Physiology Pennsylvania State University College of MedicineHersheyPA 17033USA

Telomerase expression and telomere maintenance are critical for long-term cell proliferation and survival,and they play important roles in development,aging,and *** evidence has indicated that regulation of the rate-limiting subunit of human telomerase reverse transcriptase gene(hTERT)is a complex process in normal cells and many cancer *** addition to a number of transcriptional activators and repressors,the chromatin environment and epigenetic status of the endogenous hTERT locus are also pivotal for its regulation in normal human somatic cells and in tumorigenesis.

关键词： telomerase transcriptional regulation chromatin epigenetic regulation cancer