Epigenetic regulation of B cells and its role in autoimmune pathogenesis

作     者：Fan Xiao Ke Rui Xiaofei Shi Haijing Wu Xiaoyan Cai Kathy O.Lui Qianjin Lu Esteban Ballestar Jie Tian Hejian Zou Liwei Lu 

作者机构：Department of PathologyShenzhen Institute of Research and Innovation and Shenzhen HospitalThe University of Hong KongHong KongChongqing International Institute for ImmunologyChongqingChina Institute of Medical ImmunologyAffiliated Hospital of Jiangsu UniversityZhenjiangChina Department of Rheumatology and ImmunologyThe First Affiliated Hospital and School of MedicineHenan University of Science and TechnologyLuoyangChina Department of DermatologySecond Xiangya HospitalCentral South UniversityHunan Key Laboratory of Medical EpigenomicsChangshaHunanChina Department of RheumatologyGuangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina Department of Chemical PathologyFaculty of MedicinePrince of Wales HospitalThe Chinese University of Hong KongHong KongChina Epigenetics and Immune Disease GroupJosep Carreras Research InstituteBadalona08916 BarcelonaSpain Epigenetics in Inflammatory and Metabolic Diseases LaboratoryHealth Science CenterEast China Normal UniversityShanghaiChina Department of RheumatologyHuashan HospitalFudan UniversityShanghaiChina Centre for Oncology and ImmunologyHong Kong Science ParkHong KongChina 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2022年第19卷第11期

页      面：1215-1234页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：This work was supported by Chongqing International Institute for Immunology(2020YJC10) National Natural Science Foundation of China(82071817,91842304,82171771,and 82271854) Shenzhen Science and Technology Program(JCYJ20210324114602008) Hong Kong Research Grants Council(17113319 and 17103821),RGC Theme-based Research Scheme(TRS)(T12-703/19-R) the Centre for Oncology and Immunology under the Health@InnoHK Initiative funded by the Innovation and Technology Commission,Hong Kong,China.The figures were created with BioRender.com. 

主　　题：B cells Epigenetic regulation Autoimmune disease Biomarker Therapy 

摘      要：B cells play a pivotal role in the pathogenesis of autoimmune diseases.Although previous studies have shown many genetic polymorphisms associated with B-cell activation in patients with various autoimmune disorders,progress in epigenetic research has revealed new mechanisms leading to B-cell hyperactivation.Epigenetic mechanisms,including those involving histone modifications,DNA methylation,and noncoding RNAs,regulate B-cell responses,and their dysregulation can contribute to the pathogenesis of autoimmune diseases.Patients with autoimmune diseases show epigenetic alterations that lead to the initiation and perpetuation of autoimmune inflammation.Moreover,many clinical and animal model studies have shown the promising potential of epigenetic therapies for patients.In this review,we present an up-to-date overview of epigenetic mechanisms with a focus on their roles in regulating functional B-cell subsets.Furthermore,we discuss epigenetic dysregulation in B cells and highlight its contribution to the development of autoimmune diseases.Based on clinical and preclinical evidence,we discuss novel epigenetic biomarkers and therapies for patients with autoimmune disorders.