检索结果-南通市图书馆

Efficacy and safety of modified medium-chain triglyceride ketogenic diet in patients with drug-resistant epilepsy

Acta Epileptologica 2024年第1期7卷 44-52页

作者： Hua Li Yao Wang Jing Guo Peiqi Zhang Zheng Xu Kai Peng Xiaoli Dong Liming Zhao Department of Neurology Guangdong Sanjiu Brain HospitalGuangzhou510510China

Background Medium-chain triglyceride ketogenic diet(MCTKD)is previously less commonly used in *** study was aimed to assess the efficacy and safety of the modified MCTKD in the treatment of drug-resistant epilepsy in Chinese *** Patients with drug-resistant epilepsy were enrolled to receive treatment with modified MCTKD in Guangdong Sanjiu Brain Hospital during December 2020 and September *** modified MCTKD contained fat that provided 50–70%of the total energy,as well as proteins and carbohydrates that provided 20–30%and 20%of energy,*** fat component was composed of 20–30%medium-chain triglycerides(MCTs)and 30–40%long-chain *** efficacy and safety of the diet were assessed at 1,3 and 6 *** A total of 123 patients aged 2.5 to 65 years,were included in this *** response rates at 1,3 and 6 months were 49.6%,43.1%,and 30.9%,*** seizure freedom rates at 1,3 and 6 months were 12.2%,10.6%,and 6.5%,*** retention rates at 1,3 and 6 months were 98.4%,65.0%and 33.3%*** effects occurred in 21.14%of patients,which were predominantly gastrointestinal symptoms such as abdominal pain,diarrhea,vomiting,and constipation,and most of them resolved after dietary adjustments.A total of 82 patients(66.7%)discontinued the treatment with the reason of refusing to eat(8.1%),poor efficacy(35.0%),poor compliance(4.9%),and inability to follow-up(9.8%).Only 4 patients(3.3%)withdrew the diet due to side *** The modified MCTKD with MCTs providing 20–30%of energy has a good safety in patients with drug-resistant epilepsy,but its effectiveness needs to be *** modifications of MCTKD with an optimal energy ratio are required to achieve a better efficacy and safety.

关键词： Medium-chain triglyceride ketogenic diet Ketogenic diet drug-resistant epilepsy Efficacy Safety

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Arterial spin labeling perfusion MRI applications in drug‑resistant epilepsy and epileptic emergency

引用

Acta Epileptologica 2023年第3期6卷 139-147页

作者： Yingchun Xu Ge Tan Deng Chen Jiao Liu Zixian Zhou Ling Liu Department Neurology Sichuan UniversityWest China HospitalGuo Xue Lane 37Chengdu 610041SichuanPR China

epilepsy affects all age groups and is one of the most common and disabling neurological disorders ***-resistant epilepsy(DRE),status epilepticus(SE),and sudden unexpected death in epilepsy(SUDEP),which are associated with considerable healthcare costs and mortality,have always been difficult to address and become the focus of clinical *** rapid identification of seizure onset and accurate localization of epileptic foci are crucial for the treatment and prognosis of people with DRE,SE,or ***,most of the conventional neuroimaging techniques for assessing cerebral blood flow of people with epilepsy are restricted by time consumption,limited resolution,and ionizing *** spin labeling(ASL)is a newly powerful non-contrast magnetic resonance imaging technique that enables the quantitative evaluation of brain perfusion,characterized by its unique advantages of reproducibility and easy *** studies have demonstrated the potential advantages of ASL for the diagnosis and evaluation of ***,in this review,we discussed the complementary value of ASL in evaluating and characterizing the basic substrates underlying refractory epilepsy and epileptic emergencies.

关键词： Arterial spin labeling Cerebral blood flow drug-resistant epilepsy Epileptic emergency Status epilepticus SUDEP

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Review of the Surgical Procedures for the Treatment of drug-resistant epilepsy and Their Seizure Control Outcomes

引用

Surgical Science 2023年第8期14卷 533-549页

作者： Talal Salem Cohen Chetty Ochran Chetty Faculty of Medicine Masaryk University Brno Czech Republic

Background: drug-resistant epilepsy can be defined as the existence of seizures within 6 months, despite adequate therapy regimens with one or more antiepileptic drugs. epilepsy surgery has been the standard therapy to help those patients who suffer from drug-resistant epilepsy. The goal of this surgery is to halt or reduce the intensity of seizures. This literature review aims to provide an overview of existing surgical procedures for the treatment of drug-resistant epilepsy and the degree of seizure control they provide based on available literature. Methods: Data were collected from medical journal databases, aggregators, and individual publications. The most used databases were PubMed, Medline and NCBI. Some of the keywords used to search these databases include: “drug resistant epilepsy”, “seizure control”, and “neurosurgery”. Results: Epileptic surgery is divided into resective and non-resective procedures. Studies have shown that a full resection of the epileptogenic brain area increases the probability of seizure eradication, however, the risks of postoperative impairments grow as the resection area is extended. On the other hand, patients who are unsuitable for seizure focus removal by resective surgery, such as those with multifocal seizures or overlapping epileptogenic zone with a functional cortex, may benefit from non-resective surgical options such as Vagus Nerve Stimulation and Responsive Neurostimulation. Conclusion: This literature review discusses the comprehensive treatment of epilepsy, especially the surgical treatment of drug-resistant epilepsy. The reviewed studies have shown that epilepsy surgery has promising outcomes in achieving seizure freedom/reducing seizure frequency with minimal adverse effects when performed correctly with the appropriate choice of surgical candidates.

关键词： drug-resistant epilepsy Vagus Nerve Stimulation Seizure Control Neurostimulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pharmacokinetic, pharmacodynamic, and neurochemical investigations of lamotrigine-pentylenetetrazole kindled mice to ascertain it as a reliable model for clinical drug-resistant epilepsy

引用

Animal Models and Experimental Medicine 2020年第3期3卷 245-255页

作者： Sandeep Kumar Rajesh K.Goel Department of Pharmaceutical Sciences&drug Research Punjabi UniversityPatialaPunjabIndia

Background:Pentylenetetrazole kindling has long been used for the screening of investigational antiseizure *** presence of lamotrigine,at a very low dose,does not hamper kindling in mice;rather it modifies this epileptogenesis process into drug-resistant *** lamotrigine-pentylenetetrazole kindled mice show resistance to lamotrigine,phenytoin,and *** may also be possible that other licensed antiseizure drugs,like the mentioned drugs,remain ineffective in this model;therefore,this was the subject of this ***:Swiss albino mice were kindled with pentylenetetrazole for 35 days in the presence of either methylcellulose vehicle or lamotrigine(subtherapeutic dose,ie,5 mg/kg).Vehicle vs lamotrigine-kindled mice were compared in terms of(a)resistance/response toward nine antiseizure drugs applied as monotherapies and two drug combinations;(b)lamotrigine bioavailability in blood and brain;(c)blood-brain barrier integrity;and(d)amino acids and monoamines in the cerebral cortex and ***:Lamotrigine vs vehicle-kindled mice are similar(or not significantly different P>.05 from each other)in terms of(a)response toward drug combinations;(b)lamotrigine bioavailability;and(c)blood-brain barrier integrity except for,significantly(Presistant to lamotrigine(15 mg/kg),levetiracetam(40 mg/kg);carbamazepine(40 mg/kg),zonisamide(100 mg/kg),gabapentin(224 mg/kg),pregabalin(30 mg/kg),phenytoin(35 mg/kg),and topiramate(300 mg/kg).Conclusion:Lamotrigine-pentylenetetrazole kindling takes longer to develop(~5 weeks)in comparison to lamotrigine-amygdale(~4 weeks)and lamotriginecorneal(~2 weeks)kindling ***,drug screening through this model may yield superior drugs with novel antiseizure mechanisms.

关键词： animal models drug-resistant epilepsy kindling lamotrigine refractory epilepsy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The role of axon guidance molecules in the pathogenesis of epilepsy

引用

Neural Regeneration Research 2025年第5期20卷 1244-1257页

作者： Zheng Liu Chunhua Pan Hao Huang Department of Neurology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Current treatments for epilepsy can only manage the symptoms of the condition but cannot alter the initial onset or halt the progression of the disease. Consequently, it is crucial to identify drugs that can target novel cellular and molecular mechanisms and mechanisms of action. Increasing evidence suggests that axon guidance molecules play a role in the structural and functional modifications of neural networks and that the dysregulation of these molecules is associated with epilepsy susceptibility. In this review, we discuss the essential role of axon guidance molecules in neuronal activity in patients with epilepsy as well as the impact of these molecules on synaptic plasticity and brain tissue remodeling. Furthermore, we examine the relationship between axon guidance molecules and neuroinflammation, as well as the structural changes in specific brain regions that contribute to the development of epilepsy. Ample evidence indicates that axon guidance molecules, including semaphorins and ephrins, play a fundamental role in guiding axon growth and the establishment of synaptic connections. Deviations in their expression or function can disrupt neuronal connections, ultimately leading to epileptic seizures. The remodeling of neural networks is a significant characteristic of epilepsy, with axon guidance molecules playing a role in the dynamic reorganization of neural circuits. This, in turn, affects synapse formation and elimination. Dysregulation of these molecules can upset the delicate balance between excitation and inhibition within a neural network, thereby increasing the risk of overexcitation and the development of epilepsy. Inflammatory signals can regulate the expression and function of axon guidance molecules, thus influencing axonal growth, axon orientation, and synaptic plasticity. The dysregulation of neuroinflammation can intensify neuronal dysfunction and contribute to the occurrence of epilepsy. This review delves into the mechanisms associated with

关键词： axon guidance drug-resistant epilepsy epilepsy nerve regeneration nervous system diseases neural pathways neuroinflammatory diseases neuronal plasticity neurons synaptic remodeling

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Young children with multidrug-resistant epilepsy and vagus nerve stimulation responding to perampanel: A case report

引用

World Journal of Clinical Cases 2022年第11期10卷 3511-3517页

作者： Hua Yang Dan Yu Department of Pediatrics West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina

BACKGROUND Perampanel(PER),a third-generation antiepileptic drug,is a selective and noncompetitiveα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist,and has been approved for the treatment of adults and adolescents with focal ***,there are only a few studies about the efficacy and tolerability of PER in young children with multidrug-resistant *** this case,we aimed to share our clinical experience in this *** SUMMARY A 4-year-old boy without perinatal asphyxia and familial history of epilepsy began to have ictal seizures from age 14 mo,with jerky movement of four limbs and head *** multifocal discharge and background activity were recorded through electroencephalography,and no pathogenic mutation was found in the whole exome sequencing for the patient and his *** had received valproate,levetiracetam,topiramate,oxcarbazepine,clonazepam and lacosamide sequentially at different times,but he still had frequent seizures even after vagus nerve stimulation(VNS)*** was diagnosed with idiopathic multidrug-resistant ***,his seizure frequency was significantly reduced after PER administration in a dose-dependent manner,and better cognitive behavior was *** addition,the adverse reactions of anger and aggression also *** PER is effective as add-on therapy for young children with multidrug-resistant epilepsy who have previously undergone VNS implantation.

关键词： Perampanel Young children drug-resistant epilepsy Vagus nerve stimulation Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neuromodulation for temporal lobe epilepsy:a scoping review

引用

Acta Epileptologica 2022年第3期5卷 145-155页

作者： Ashabilan Abdikarim Ebrahim Alexander Tungu Muhimbili University of Health and Allied Sciences PO BOX 65001Dar es SalaamTanzania

Temporal lobe epilepsy(TLE)is difficult to treat as it is often refractory to *** from traditional medical treatment,surgical resection is also a choice of treatment,but it may be associated with significant cognitive *** a result,treatment strategies using targeted and adjustable stimulation of malfunctioning brain circuits have been *** neuromodulatory therapies using approaches of electric and magnetic neuromodulation are already in clinical use for refractory epilepsy while others such as optogenetics,chemo-genetics and ultrasound modulation are being tested in pre-clinical TLE animal *** this review,we conducted an in-depth literature search on the clinically available neuromodulatory approaches for TLE,focusing on the possible mechanism of action and the clinical outcomes including adverse *** that are currently explored in preclinical animal models but may have therapeutic applications in future are also *** efficacy and subsequent adverse effects vary among the different neuromodulatory approaches and some still have unclear mechanisms of action in TLE *** studies evaluating the benefits and potential limitations are *** research on the therapeutic mechanisms and the epileptic brain network is critical for improving therapies for TLE.

关键词： Deep brain stimulation drug-resistant epilepsy Neurostimulation Vagus nerve stimulation Transcranial direct current stimulation Transcranial magnetic stimulation

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe epilepsy

引用

World Journal of Clinical Cases 2021年第34期9卷 10518-10529页

作者： Yan-En Lyu Xiao-Fei Xu Shuang Dai Min Feng Shao-Ping Shen Guo-Zhen Zhang Hong-Yan Ju Yao Wang Xiao-Bo Dong Bin Xu Seventh Clinical School of Medicine Beijing University of Chinese MedicineTongchuan 727031Shaanxi ProvinceChina Neurosurgery and epilepsy Centre Dongzhimen HospitalBeijing University of Chinese MedicineBeijing 100700China Neurosurgery and epilepsy Centre General Hospital of Beijing Military Commanding RegainBeijing 100700China

BACKGROUND Neurosurgical treatment of severe bilateral occipital lobe epilepsy usually involves two operations several mos *** To evaluate surgical resection of bilateral occipital lobe lesions during a single operation as a treatment for bilateral occipital lobe *** This retrospective case series included patients with drug-refractory bilateral occipital lobe epilepsy treated surgically between March 2006 and November *** Preoperative evaluation included scalp video-electroencephalography(EEG),magnetic resonance imaging,and *** surgery(bilateral occipital craniotomy),epileptic foci and important functional areas were identified by EEG(intracranial cortical electrodes)and cortical functional mapping,*** were followed up for at least 5 years to evaluate treatment outcome(Engel grade)and visual *** 20 patients(12 males)were aged 4-30 years(median age,12 years).Time since onset was 3-20 years(median,8 years),and episode frequency was 4-270/mo(median,15/mo).Common manifestations were elementary visual hallucinations(65.0%),flashing lights(30.0%),blurred vision(20.0%)and visual field defects(20.0%).Most patients were free of disabling seizures(Engel grade I)postoperatively(18/20,90.0%)and at 1 year(18/20,90.0%),3 years(17/20,85.0%)and≥5 years(17/20,85.0%).No patients were classified Engel grade IV(no worthwhile improvement).After surgery,there was no change in visual function in 13/20(65.0%),development of a new visual field defect in 3/20(15.0%),and worsening of a preexisting defect in 4/20(20.0%).CONCLUSION Resection of bilateral occipital lobe lesions during a single operation may be applicable in bilateral occipital lobe epilepsy.

关键词： drug-resistant epilepsy Occipital lobe epilepsy Bilateral lesions One-stage surgery Treatment outcome Visual fields

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ketogenic dietary therapy in adult status epilepticus:current progress and clinical application

引用

Acta Epileptologica 2022年第2期5卷 71-77页

作者： Mengting Cail Wanyin Xu Yang Zheng Meiping Ding Department of Neurology School of MedicineSecond Afliated HospitalZhejiang University310009 HangzhouChina Department of Nutrition Zhejiang Provincial Hospital of Chinese MedicineHangzhou 310009China Department of Neurology Zhejiang Provincial Hospital of Chihese MedicineHangzhou 310009China.

Status epilepticus(SE)is a common fatal neurological disease with high morbidity and mortality,Even if a large proportion of patients might be relieved from anti-seizure medications,sedatives and anesthetics,some still remain out of *** ketogenic dietary(KD)has been proven useful in patients refractory to medications and/or who have failed to respond to surgical ***,KD has shown beneficial therapeutic effects in children with SE,but studies in adults have rarely been *** this paper,we review the efficacy and utility of KD in adult SE patients and highlight its application for clinical reference and management.

关键词： Adults drug-resistant epilepsy Ketogenic enteral nutrition Ketogenic dietary Ketogenic parenteral nutrition Management Status epilepticus

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Brief potentially ictal rhythmic discharges on intraoperative electrocorticography predict a good outcome of focal cortical dysplasia after surgical resection: a case report

引用

Acta Epileptologica 2023年第3期6卷 163-167页

作者： Sofía S.Sánchez‑Boluarte Wilfor Aguirre‑Quispe Manuel Herrera Aramburú William O.Tatum Walter De La Cruz Ramírez School of Medicine Cesar Vallejo UniversityAv.Victor LarcoTrujilloTrujillo 1770Peru Departamento de Epilepsia Instituto Nacional de Ciencias NeurológicasJr.Ancash 1271LimaLima 15001Peru Neurosciences Clinical Effectiveness and Public Health Research GroupUniversidad Científica del SurPanamericana Sur 19Villa EL SalvadorLimaLima 15067Peru Department of Neurology Mayo ClinicMangurian Bldg.Fourth Floor4500 San Pablo RoadFL 32224 JacksonvilleUSA

Background Focal cortical dysplasia(FCD)is a common cause of drug-resistant ***(EEG)biomarkers that predict good postoperative outcomes are essential for identifying patients with focal *** presentation We report the case of a 21-year-old female with seizure onset at the age of 9,characterized by left-hand dystonic posturing and impaired awareness,which evolved to bilateral tonic-clonic seizures,evaluated in a neurological referral center in Lima,*** 6-h video-EEG,interictal EEG revealing focal brief potentially ictal rhythmic discharges(BIRDs)over the right frontal central region,lasting less than 10 *** ictal features were characterized by low-voltage fast activity over the same *** magnetic resonance imaging(MRI)demonstrated a focal lesion of focal cortical dysplasia type II in the right frontal *** patient underwent a lesionectomy guided by electrocorticography,which showed continuous *** showing a brief burst of spikes lasting longer than 0.5 s,were also identified on intraoperative electrocorticography(ECoG)and helped define the extent of *** patient obtained an Engel Outcome Class IA at 6 years of *** The atypical BIRDs on ECoG can be used as a prognostic biomarker for prolonged seizure-freedom outcome in patients with *** reports are needed in developing countries with and without brain MRI lesions to advance outpatient presurgical evaluations despite limited resources.

关键词： Electrocorticography Cortical dysplasia-focal epilepsy syndrome drug-resistant epilepsy Frontal lobe epilepsy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：