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Nanoparticles modified by polydopamine: Working as “drug” carriers

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Bioactive Materials 2020年第3期5卷 522-541页

作者： Anting Jin Yitong Wang Kaili Lin Lingyong Jiang Department of Oral&Cranio-Maxillofacial Surgery Shanghai Ninth People's HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineNational Clinical Research Center for Oral DiseasesShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyShanghai200011PR China

Inspired by the mechanism of mussel adhesion,polydopamine(PDA),a versatile polymer for surface modification has been *** to its unique properties like extraordinary adhesiveness,excellent biocompatibility,mild synthesis requirements,as well as distinctive drug loading approach,strong photothermal conversion capacity and reactive oxygen species(ROS)scavenging facility,various PDA-modified nanoparticles have been desired as drug *** nanoparticles with diverse nanostructures are exploited in multifunctions,consisting of targeting,imaging,chemical treatment(CT),photodynamic therapy(PDT),photothermal therapy(PTT),tissue regeneration ability,therefore have attracted great attentions in plenty biomedical ***,recent progress of PDA-modified nanoparticle drug carriers in cancer therapy,antibiosis,prevention of inflammation,theranostics,vaccine delivery and adjuvant,tissue repair and implant materials are reviewed,including preparation of PDA-modified nanoparticle drug carriers with various nanostructures and their drug loading strategies,basic roles of PDA surface modification,*** advantages of PDA modification in overcoming the existing limitations of cancer therapy,antibiosis,tissue repair and the developing trends in the future of PDA-modified nanoparticle drug carriers are also discussed.

关键词： Surface modification Polydopamine Nanoparticles drug carriers

Nanoparticles for the treatment of spinal cord injury

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Neural Regeneration Research 2025年第6期20卷 1665-1680页

作者： Qiwei Yang Di Lu Jiuping Wu Fuming Liang Huayi Wang Junjie Yang Ganggang Zhang Chen Wang Yanlian Yang Ling Zhu Xinzhi Sun Department of Orthopedic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijingChina University of Chinese Academy of Sciences BeijingChina Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical UniversityChongqingChina

Spinal cord injuries lead to significant loss of motor, sensory, and autonomic functions, presenting major challenges in neural regeneration. Achieving effective therapeutic concentrations at injury sites has been a slow process, partly due to the difficulty of delivering drugs effectively. Nanoparticles, with their targeted delivery capabilities, biocompatibility, and enhanced bioavailability over conventional drugs, are garnering attention for spinal cord injury treatment. This review explores the current mechanisms and shortcomings of existing treatments, highlighting the benefits and progress of nanoparticle-based approaches. We detail nanoparticle delivery methods for spinal cord injury, including local and intravenous injections, oral delivery, and biomaterial-assisted implantation, alongside strategies such as drug loading and surface modification. The discussion extends to how nanoparticles aid in reducing oxidative stress, dampening inflammation, fostering neural regeneration, and promoting angiogenesis. We summarize the use of various types of nanoparticles for treating spinal cord injuries, including metallic, polymeric, protein-based, inorganic non-metallic, and lipid nanoparticles. We also discuss the challenges faced, such as biosafety, effectiveness in humans, precise dosage control, standardization of production and characterization, immune responses, and targeted delivery in vivo. Additionally, we explore future directions, such as improving biosafety, standardizing manufacturing and characterization processes, and advancing human trials. Nanoparticles have shown considerable progress in targeted delivery and enhancing treatment efficacy for spinal cord injuries, presenting significant potential for clinical use and drug development.

关键词： antioxidants axon regeneration biocompatible materials drug carriers nanoparticles nerve regeneration neuroinflammatory diseases neuroprotection spinal cord injury stem cells

An implantable antibacterial drug-carrier:Mesoporous silica coatings with size-tunable vertical mesochannels

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Nano Research 2022年第5期15卷 4243-4250页

作者： Mengli Liu Fang Huang Chin-Te Hung Liwei Wang Wei Bi Yupu Liu Wei Li Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Lab of Molecular Catalysis and Innovative Materialsand State Key Laboratory of Molecular Engineering of PolymersFudan UniversityShanghai 200433China Zhongshan Hospital Fudan University(Xiamen Branch)Xiamen 361015China Department of Stomatology Zhongshan HospitalFudan UniversityShanghai 200032China

Implant-associated bacterial infection remains one of the most common and serious ***,a surface boasting long-term antibacterial ability for implants is highly ***,mesoporous silica coatings(MSCs)with vertical and size-tunable mesochannels are fabricated on a variety of metal substrates via a nano-interfacial oriented assembly *** facile and versatile approach relies on the vertically oriented fusion of composite micelles on the nanoscale flatness surface of *** orientation assembly process endows the MSCs with vertical mesochannels,tunable mesopore size(ca.5.5-13.5 nm),and switchable substrates even with complex and diversified ***,the MSCs on titanium substrates(Ti@MSCs)exhibit excellent performances for drug adsorption and sustained *** saturation adsorption capacity can reach 0.544 μg·cm^(-2) towards minocycline hydrochloride(MC-HCl)antibiotic molecules,which is 6.5 times as the bare titanium(Ti)*** addition,the drug release time can be controlled from 84 to 216 h by simply adjusting the mesopore *** a proof of concept,the Ti@MSCs can realize a higher antibacterial rate(95.9%),compared with the bare Ti(70.3%).The results highlight the high potential of MSCs as implant coating for long-term preventing and eliminating peri-implantitis.

关键词： mesoporous coatings silica vertical mesochannels metal substrates drug carriers

Functionalized magnetic nanoparticles for drug delivery in tumor therapy

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Chinese Physics B 2021年第1期30卷 87-93页

作者： Ruo-Nan Li Xian-Hong Da Xiang Li Yun-Shu Lu Fen-Fen Gu Yan Liu School of Materials Science and Engineering University of Shanghai for Science and TechnologyShanghai 200093China Department of General Surgery Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of Pharmacy Xinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China

The side effects of chemotherapy are mainly the poor control of drug release. Magnetic nanoparticles(MNPs) have super-paramagnetic behaviors which are preferred for biomedical applications such as in targeted drug delivery, besides, in magnetic recording, catalysis, and others. MNPs, due to high magnetization response, can be manipulated by the external magnetic fields to penetrate directly into the tumor, thus they can act as ideal drug carriers. MNPs also play a crucial role in drug delivery system because of their high surface-to-volume ratio and porosity. The drug delivery in tumor therapy is related to the sizes, shapes, and surface coatings of MNPs as carriers. Therefore, in this review, we first summarize the effects of the sizes, shapes, and surface coatings of MNPs on drug delivery, then discuss three types of drug release systems, i.e., p H-controlled, temperature-controlled, and magnetic-controlled drug release systems, and finally compare the principle of passive drug release with that of active drug release in tumor therapy.

关键词： magnetic nanoparticles tumor drug carriers targeted therapy

An update on oral drug delivery via intestinal lymphatic transport

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Acta Pharmaceutica Sinica B 2021年第8期11卷 2449-2468页

作者： Zichen Zhang Yi Lu Jianping Qi Wei Wu Key Laboratory of Smart drug Delivery of MOE School of PharmacyFudan UniversityShanghai 201203China Center for Medical Research and Innovation Shanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China

Orally administered drug entities have to survive the harsh gastrointestinal environment,penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic *** the gastrointestinal stability can be well maintained by taking proper measures,hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass *** pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal *** lymphatic transport is emerging as a promising pathway to this *** this review,we intend to provide an updated overview on the rationale,strategies,factors and applications involved in intestinal lymphatic *** are mainly two pathways for peroral lymphatic transportdthe chylomicron and the microfold cell *** underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.

关键词： drug delivery Oral Lymphatic transport drug absorption Chylomicron Microfold cell drug carriers Nanoparticles

Hydrogel-based local drug delivery strategies for spinal cord repair

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Neural Regeneration Research 2021年第2期16卷 247-253页

作者： Robert B.Shultz Yinghui Zhong School of Biomedical Engineering Science and Health SystemsDrexel UniversityPhiladelphiaPAUSA Department of Neurosurgery University of PennsylvaniaPhiladelphiaPAUSA Department of Bioengineering University of PennsylvaniaPhiladelphiaPAUSA New Jersey Center for Biomaterials Rutgers–The State University of New JerseyPiscatawayNJUSA Center for Neurotrauma Neurodegeneration&RestorationCorporal Michael J.Crescenz Veterans Affairs Medical CenterPhiladelphiaPAUSA

Spinal cord injury results in significant loss of motor, sensory, and autonomic functions. Although a wide range of therapeutic agents have been shown to attenuate secondary injury or promote regeneration/repair in animal models of spinal cord injury, clinical translation of these strategies has been limited, in part due to difficulty in safely and effectively achieving therapeutic concentrations in the injured spinal cord tissue. Hydrogelbased drug delivery systems offer unique opportunities to locally deliver drugs to the injured spinal cord with sufficient dose and duration, while avoiding deleterious side effects associated with systemic drug administration. Such local drug delivery systems can be readily fabricated from biocompatible and biodegradable materials. In this review, hydrogel-based strategies for local drug delivery to the injured spinal cord are extensively reviewed, and recommendations are made for implementation.

关键词： drug carriers drug delivery hydrogels microparticles nanoparticles neurotrophic factors scaffolds spinal cord injury

Nanomedicine Disrupts Stromal Barriers to Augment drug Penetration for Improved Cancer Therapy

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Chinese Journal of Chemistry 2024年第10期42卷 1175-1189页

作者： Guo-Feng Luo Wei-Hai Chen Xian-Zheng Zhang state Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei KeyLaboratory of StomatologySchool&Hospital of StomatologyWuhan UniversityWuhanHubei 430079China Key Laboratoryof Biomedical Polymers of Ministry of Education&Departmentof Chemistry Wuhan UniversityWuhanHubei 430072China

Tumor stroma composing diverse extracellular matrixes(ECM)and stromal cells shapes a condensed physical barrier,which severely hampers the efficient accessibility of nanomedicine to tumor cells,especially these deep-seated in the core of *** barrier significantly compromises the antitumor effects of drug-loaded nanomedicine,revealing the remarkable importance of disrupting stromal barrier for improved tumor therapy with deep penetration *** achieve this goal,various nanoparticle-based strategies have been developed,including direct depleting ECM components via delivering anti-fibrotic agents or targeting stromal cells to suppress ECM expression,dynamic regulation of nanoparticles’physicochemical properties(i.e.,size,surface charge,and morphology),mechanical force-driven deep penetration,natural/biomimetic self-driven nanomedicine,and transcytosis-inducing *** these nanostrategies were systemically summarized in this review,and the design principles for obtaining admirable nanomedicine were *** the rapid development of nanotechnology,elaborate design of multifunctional nanomedicine provides new opportunities for overcoming the critical stromal barriers to maximize the therapeutic index of various therapies,such as chemotherapy,photodynamic therapy,and immunotherapy.

关键词： Nanomedicine Tumor stroma Deep penetration Enhanced drug perfusion Cancer therapy drug carriers Biomaterials Nanotechnology

Applications of PLA in modern medicine

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Engineered Regeneration 2020年第1期1卷 76-87页

作者： Vincent DeStefano Salaar Khan Alonzo Tabada Department of Biomedical Engineering Stony Brook UniversityStony BrookNY 11794USA

Polylactic acid(PLA)is a versatile *** is synthesized with ease from abundant renewable resources and is *** has shown promise as a biomaterial in a plethora of healthcare applications such as tissue engineering or regenerative medicine,cardiovascular implants,dental niches,drug carriers,orthopedic in-terventions,cancer therapy,skin and tendon healing,and lastly medical tools/*** has demonstrated instrumental importance as a three-dimensionally(3D)printable biopolymer,which has further been bolstered by its role during the Coronavirus Disease of 2019(Covid-19)global *** an abundant filament,PLA has created desperately needed personal protective equipment(PPE)and ventilator *** polymer chemistry continues to advance,so too will the applications and continued efficacy of PLA-based modalities.

关键词： Polylactic acid Polymers Tissue engineering Cardiovascular drug carriers Dental Orthopedics Cancer therapy skin/tendon healing surgical tools

Cell-mediated and cell membrane-coated nanoparticles for drug delivery and cancer therapy

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Cancer drug Resistance 2020年第4期3卷 879-911页

作者： Serkan Yaman Uday Chintapula Edgar Rodriguez Harish Ramachandramoorthy Kytai T.Nguyen Department of Bioengineering University of Texas at ArlingtonArlingtonTX 76010USA Joint Bioengineering Program University of Texas Southwestern Medical CenterDallasTX 75235USA

Nanotechnology-based drug delivery platforms have been developed over the last two decades because of their favorable features in terms of improved drug bioavailability and *** recent advancement in nanotechnology platforms,this approach still falls short to meet the complexity of biological systems and diseases,such as avoiding systemic side effects,manipulating biological interactions and overcoming drug resistance,which hinders the therapeutic outcomes of the NP-based drug delivery *** address these issues,various strategies have been developed including the use of engineered cells and/or cell membrane-coated *** membrane receptor profiles and characteristics are vital in performing therapeutic functions,targeting,and homing of either engineered cells or cell membrane-coated nanocarriers to the sites of *** this context,we comprehensively discuss various cell-and cell membrane-based drug delivery approaches towards cancer therapy,the therapeutic potential of these strategies,and the limitations associated with engineered cells as drug carriers and cell membrane-associated drug ***,we review various cell types and cell membrane receptors for their potential in targeting,immunomodulation and overcoming drug resistance in cancer.

关键词： Cell membrane-based drug delivery cell-mediated drug delivery membrane receptors drug carriers cancer drug resistance nanoparticles