Functionalized magnetic nanoparticles for drug delivery in tumor therapy

作     者：Ruo-Nan Li Xian-Hong Da Xiang Li Yun-Shu Lu Fen-Fen Gu Yan Liu 李若男;达先鸿;李翔;陆云姝;顾芬芬;刘艳

作者机构：School of Materials Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Department of General SurgeryXinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China Department of PharmacyXinhua HospitalAffiliated to Shanghai Jiao Tong University School of MedicineShanghai 200092China 

出 版 物：《Chinese Physics B》 (中国物理B（英文版）)

年 卷 期：2021年第30卷第1期

页      面：87-93页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Project supported by the National Natural Science Foundation of China(Grant Nos.52072245,61771092,and 81702588) the Natural Science Foundation of Shanghai,China(Grant No.17ZR1419700) 

主　　题：magnetic nanoparticles tumor drug carriers targeted therapy 

摘      要：The side effects of chemotherapy are mainly the poor control of drug release. Magnetic nanoparticles(MNPs) have super-paramagnetic behaviors which are preferred for biomedical applications such as in targeted drug delivery, besides, in magnetic recording, catalysis, and others. MNPs, due to high magnetization response, can be manipulated by the external magnetic fields to penetrate directly into the tumor, thus they can act as ideal drug carriers. MNPs also play a crucial role in drug delivery system because of their high surface-to-volume ratio and porosity. The drug delivery in tumor therapy is related to the sizes, shapes, and surface coatings of MNPs as carriers. Therefore, in this review, we first summarize the effects of the sizes, shapes, and surface coatings of MNPs on drug delivery, then discuss three types of drug release systems, i.e., p H-controlled, temperature-controlled, and magnetic-controlled drug release systems, and finally compare the principle of passive drug release with that of active drug release in tumor therapy.