An update on oral drug delivery via intestinal lymphatic transport

作     者：Zichen Zhang Yi Lu Jianping Qi Wei Wu Zichen Zhang;Yi Lu;Jianping Qi;Wei Wu

作者机构：Key Laboratory of Smart Drug Delivery of MOESchool of PharmacyFudan UniversityShanghai 201203China Center for Medical Research and InnovationShanghai Pudong HospitalFudan University Pudong Medical CenterShanghai 201399China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2021年第11卷第8期

页      面：2449-2468页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China(Nos.81872815,82030107,and 81690263) Science and Technology commission of Shanghai Municipality(No.19XD1400300,China) 

主　　题：Drug delivery Oral Lymphatic transport Drug absorption Chylomicron Microfold cell Drug carriers Nanoparticles 

摘      要：Orally administered drug entities have to survive the harsh gastrointestinal environment,penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic *** the gastrointestinal stability can be well maintained by taking proper measures,hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass *** pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal *** lymphatic transport is emerging as a promising pathway to this *** this review,we intend to provide an updated overview on the rationale,strategies,factors and applications involved in intestinal lymphatic *** are mainly two pathways for peroral lymphatic transportdthe chylomicron and the microfold cell *** underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.