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DESIGN OF MICROPHYSIOMETER BASED ON MULTIPARAMETER CELL-BASED BIOSENSORS FOR QUICK drug analysis

Journal of Innovative Optical Health Sciences 2012年第1期5卷 36-47页

作者： NING HU DA HA CHENGXIONG WU GONG CHENG HUI YU TIANXING WANG JIEYING WU HUA CAI QINGJUN LIU PING WANG Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang University Hangzhou 310027P.R.China ACEA Bioscience Inc.West Lake Technology and Economy Park Hangzhou 310030 P.R.China

Cellular metabolism arouses the changes of substance in extracellular physiological microenvironment,and the metabolic level reflects the physiological state of *** paper developed a novel microphysiometer automatic analysis instrument based on multiparameter cell-based biosensors for quick drug *** study included the multiparameter cell-based biosensors,cell culture chamber,drug auto-injection detection and *** analysis instrument was capable of real-time detection for the acidic product and other chemical parameters generated by the cellular metabolism in the ***,the paper employs human breast cancer cell line MCF-7 and drug experiments to verify the performance of microphysiometer,and study effects of different drugs on cell ***,the research explores drug analysis method of the multiparameter *** results showed that the cell-based microphysiometer system provides a utility platform for rapid,long-term and automatic cell physiological environment detection and drug analysis.

关键词： Microphysiometer multiparameter cell-based biosensor extracellular acidification cancer cells drug analysis

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Surface-assisted laser desorption/ionization mass spectrometry for drug and metabolite analysis

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Journal of Chinese Pharmaceutical Sciences 2020年第8期29卷 577-590页

作者： Wen Ma Shuxiang Song Jun Li State Key Laboratory of Natural and Biomimetic drugs School of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China

Surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)uses inorganic nanomaterials as matrixes to facilitate desorption and ionization of *** with the traditional matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)technique,SALDI-MS has the advantages of less interference in the low mass range,better reproducibility and higher salt *** is highly suitable for the analysis of small molecule *** recent years,researchers have developed a range of nanomaterials that are successfully applied to the field of small molecule drug and metabolite analysis including drug screening and quantification,drug delivery,metabolite profiling,biomarker discovery and so *** review summarizes the latest progress of SALDI-MS matrix materials such as metal-based,carbon-based,silica-based nanomaterials and organic framework nanomaterials and their *** addition,our perspective of SALDI-MS technology is also discussed for further advancement.

关键词： Laser desorption/ionization mass spectrometry drug analysis Metabolite detection Nanomaterial

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Pharmaceutical applications of framework nucleic acids

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Acta Pharmaceutica Sinica B 2022年第1期12卷 76-91页

作者： Liang Chen Jie Zhang Zhun Lin Ziyan Zhang Miao Mao Jiacheng Wu Qian Li Yuanqing Zhang Chunhai Fan School of Pharmaceutical Sciences Sun Yat-sen UniversityGuangzhou 510006China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules and National Center for Translational MedicineShanghai Jiao Tong UniversityShanghai 200240China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acids Chemistry and NanomedicineRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200127China

DNA is a biological polymer that encodes and stores genetic information in all living organism. Particularly, the precise nucleobase pairing inside DNA is exploited for the self-assembling of nanostructures with defined size, shape and functionality. These DNA nanostructures are known as framework nucleic acids(FNAs) for their skeleton-like features. Recently, FNAs have been explored in various fields ranging from physics, chemistry to biology. In this review, we mainly focus on the recent progress of FNAs in a pharmaceutical perspective. We summarize the advantages and applications of FNAs for drug discovery, drug delivery and drug analysis. We further discuss the drawbacks of FNAs and provide an outlook on the pharmaceutical research direction of FNAs in the future.

关键词： DNA nanotechnology Self-assembly Framework nucleic acids DNA nanostructures drug discovery Therapeutic molecules drug delivery drug analysis

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Investigation on Voltammetric Behavior of Camptothecin and Its Analytical Application

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Chinese Journal of Chemistry 2006年第4期24卷 551-556页

作者：郑建斌孟祖超刘波张宏芳 Shaanxi Provincial Key Laboratory of Electroanalytical Chemistry Institute of Analytical Science Northwest University Xi'an Shaanxi 710069 China

The voltammetric behavior of camptothecin （CPT） in Britton-Robinson （B-R） buffer solutions （pH 2.09-9.07） was studied by the means of linear sweep voltammetry （LSV）, cyclic voltarnmetry （CV） and normal pulse voltammetry （NPV） at a hanging mercury drop electrode. In different pH range of B-R buffer solutions, CPT could cause three reduction waves. In B-R buffer solutions （pH 2.09-5.46）, wave P1 yielded by CPT was a two-electron wave. Between pH 6.01 and 9.07, CPT could yield two reduction waves P2 and P3. In addition, the pure CPT obtained from camptotheca acumina grown only in China was determined by NPV, and a linear response was observed in the range of 2.0 × 10^-3-4.0 × 10^-2 mmol·L^-1 with a 0.9991 correlation coefficient and a 8.0 × 1^-4 mmol·L^-1 detection limit for CPT.

关键词： camptothecin drug analysis catalytic hydrogen wave mercury electrode voltammetry

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Bi_(2)O_(3)/ZnO nanocomposite:Synthesis,characterizations and its application in electrochemical detection of balofloxacin as an antibiotic drug

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Journal of Pharmaceutical analysis 2021年第1期11卷 57-67页

作者： Sana Ansari M.Shahnawaze Ansari Soami P.Satsangee Rajeev Jain Department of Chemistry Dayalbagh Educational InstituteDayalbaghAgra282005India Center of Nanotechnology King Abdulaziz UniversityJeddah21589Saudi Arabia Advanced Membrane Technology Research Centre(AMTEC) Universiti Teknologi Malaysia81310SkudaiJohorMalaysia School of Chemical and Energy Engineering Universiti Teknologi Malaysia81310SkudaiJohorMalaysia School of Studies in Chemistry Jiwaji UniversityGwalior474011India

In the present work,a chemically modified electrode has been fabricated utilizing Bi_(2)O_(3)/ZnO *** nanocomposite was synthesized by simple sonochemical method and characterized for its structural and morphological properties by using XRD,FESEM,EDAX,HRTEM and XPS *** results clearly indicated co-existence of Bi_(2)O_(3) and ZnO in the nanocomposite with chemical interaction between ***_(2)O_(3)/ZnO nanocomposite based glassy carbon electrode(GCE)was utilized for sensitive voltammetric detection of an anti-biotic drug(balofloxacin).The modification amplified the electroactive surface area of the sensor,thus providing more sites for oxidation of *** and square wave voltammograms revealed that Bi_(2)O_(3)/ZnO modified electrode provides excellent electrocatalytic action towards balofloxacin *** current exhibited a wide linear response in concentration range of 150e1000 nM and detection limit of 40.5 nM was *** modified electrode offered advantages in terms of simplicity of preparation,fair stability(RSD 1.45%),appreciable reproducibility(RSD 2.03%)and *** proposed sensor was applied for determining balofloxacin in commercial pharmaceutical formulations and blood serum samples with the mean recoveries of 99.09% and 99.5%,respectively.

关键词： ZnO nanoparticles Chemically modified electrode Voltammetry drug analysis

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Derivative Spectrophotometric and Isocratic High Performance Liquid Chromatographic Methods for Simultaneous Determination of Repaglinide and Metformin Hydrochloride in Pharmaceutical Preparations

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American Journal of Analytical Chemistry 2017年第9期8卷 541-552页

作者： Serap Saglik Aslan Berna Yilmaz Department of Analytical Chemistry Faculty of PharmacyIstanbul UniversityIstanbulTurkey

In this study, a derivative spectrophotometric method and one HPLC method were developed and validated for analysis of anti-diabetic drugs, repaglinide (RPG) and metformine hydrochloride (MTF) in tablets. The spectrophotometric methods were based on zero-crossing first-derivative and fourth-derivative spectrophotometric method for simultaneous analysis of RPG (308 nm) and MTF (267 nm), respectively. Linear relationship between the absorbance at λmax and the drug concentration was found to be in the ranges of 5.0 - 50.0 μg·mL-1 for both RPG and MTF. The quantification limits for RPG and MTF were found to be 0.568 and 1.156 μg·mL-1, respectively. The detection limits were 0.170 and 0.347 μg·mL-1 for RPG and MTF, respectively. The second method is a rapid stability-indicating isocratic HPLC method developed for the determination of RPG and MTF. A linear response was observed within the concentration range of 5.0 - 50.0 μg·mL-1 for both RPG and MTF. The quantification limits for RPG and MTF were found to be 1.821 and 1.653 μg·mL-1, respectively. The detection limits were 0.601 and 0.545 μg·mL-1 for RPG and MTF, respectively. The proposed methods were successfully applied to the tablet analysis with good accuracy and precision.

关键词： Repaglinide Metformin Derivative Spectrophotometry HPLC drug analysis

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