Surface-assisted laser desorption/ionization mass spectrometry for drug and metabolite analysis

作     者：Wen Ma Shuxiang Song Jun Li 马雯;宋书香;李军

作者机构：State Key Laboratory of Natural and Biomimetic DrugsSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2020年第29卷第8期

页      面：577-590页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 100704[医学-药物分析学] 10[医学] 

基　　金：State Key Laboratory of Natural and Biomimetic Drugs(Peking University) the National Natural Science Foundation of China(Grant No.21804123) 

主　　题：Laser desorption/ionization mass spectrometry Drug analysis Metabolite detection Nanomaterial 

摘      要：Surface-assisted laser desorption/ionization mass spectrometry(SALDI-MS)uses inorganic nanomaterials as matrixes to facilitate desorption and ionization of *** with the traditional matrix-assisted laser desorption/ionization mass spectrometry(MALDI-MS)technique,SALDI-MS has the advantages of less interference in the low mass range,better reproducibility and higher salt *** is highly suitable for the analysis of small molecule *** recent years,researchers have developed a range of nanomaterials that are successfully applied to the field of small molecule drug and metabolite analysis including drug screening and quantification,drug delivery,metabolite profiling,biomarker discovery and so *** review summarizes the latest progress of SALDI-MS matrix materials such as metal-based,carbon-based,silica-based nanomaterials and organic framework nanomaterials and their *** addition,our perspective of SALDI-MS technology is also discussed for further advancement.