DESIGN OF MICROPHYSIOMETER BASED ON MULTIPARAMETER CELL-BASED BIOSENSORS FOR QUICK DRUG ANALYSIS
作者机构：Biosensor National Special Laboratory Key Laboratory for Biomedical Engineering of Education Ministry Department of Biomedical Engineering Zhejiang UniversityHangzhou 310027P.R.China ACEA Bioscience Inc.West Lake Technology and Economy Park Hangzhou 310030P.R.China
出 版 物：《Journal of Innovative Optical Health Sciences》 (创新光学健康科学杂志（英文）)
年 卷 期：2012年第5卷第1期
页 面：36-47页
核心收录：
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
基 金：This work was supported by the National Natural Science Foundation of China(Grant No.81027003) the Zhejiang Provincial Science and Technology Major Special Program(No.2010C14006)
主 题：Microphysiometer multiparameter cell-based biosensor extracellular acidification cancer cells drug analysis
摘 要：Cellular metabolism arouses the changes of substance in extracellular physiological microenvironment,and the metabolic level reflects the physiological state of *** paper developed a novel microphysiometer automatic analysis instrument based on multiparameter cell-based biosensors for quick drug *** study included the multiparameter cell-based biosensors,cell culture chamber,drug auto-injection detection and *** analysis instrument was capable of real-time detection for the acidic product and other chemical parameters generated by the cellular metabolism in the ***,the paper employs human breast cancer cell line MCF-7 and drug experiments to verify the performance of microphysiometer,and study effects of different drugs on cell ***,the research explores drug analysis method of the multiparameter *** results showed that the cell-based microphysiometer system provides a utility platform for rapid,long-term and automatic cell physiological environment detection and drug analysis.
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