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Sulfation modification of Dopamine in brain regulates aggregative behavior of animals

National Science Review 2022年第4期9卷 60-75页

作者： Bing Chen Xiwen Tong Xia Zhang Wanying Gui Guoming Ai Lihua Huang Ding Ding Jiangxu Zhang Le Kang School of Life Science Institutes of Life Science and Green DevelopmentHebei University State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of Sciences School of Life Sciences South China Normal University State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of Sciences

Behavioral plasticity and the underlying neuronal plasticity represent a fundamental capacity of animals to cope with environmental stimuli.Behavioral plasticity is controlled by complex molecular networks that act under different layers of regulation.While various molecules have been found to be involved in the regulation of plastic behaviors across species,less is known about how organisms orchestrate the activity of these molecules as part of a coherent behavioral response to varying environments.Here we discover a me chanism for the regulation of animal behavioral plasticity involving molecular sulfation in the brain,a modification of substrate molecules by sulfo transferase(ST)-catalyzed addition of a sulfonate group(SO3)from an obligate donor,3’-phosphoadenosine 5’-phosphosulfate(PAPS) to the substrates.We investigated aggregation behaviors of migratory locusts,which are well-known for extreme phase change plasticity triggered by population density.The processes of PAPS biosynthesis acted efficiently on induction of locust behavioral transition:Inhibition of PAPS synthesis solicited a behavioral shift from gregarious to solitarious states;external PAPS dosage,by contrast,promoted aggregation in solitarious locusts.Genetic or pharmacological intervention in the sulfation catalyzation resulted into pronounced solitarizing effects.Analysis of substrate-specific STs suggests a widespread involvement of sulfated neurotransmitters in the behavioral response.D opamine in the brain was finally identified to be actively sulfate conjugate d,and the sulfate conjugation enhanced the free DA-mediated behavioral aggregation.Similar results in Caenorhabditis elegans and mice indicate that sulfation may be involved more broadly in the modulation of animal aggregation.These findings reveal a general me chanism that effectively regulates animal social-like behavioral plasticity,possibly through sulfation-mediated modification of neural networks.

关键词： behavioral plasticity sulfation Dopamine aggregation migratory locust

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SERS and EC dual-mode detection for Dopamine based on WO_(3)-SnO_(2)nanoflake arrays

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Nano Research 2023年第3期16卷 4049-4054页

作者： Linya Lu Yan Zhou Tingting Zheng Yang Tian School of Chemistry and Molecular Engineering East China Normal UniversityShanghai 200241China State Key Laboratory of Precision Spectroscopy East China Normal UniversityShanghai 200241China

As an important neurotransmitter,the detection of Dopamine(DA)is of great significance for the diagnosis and treatment of neurological diseases.In this study,WO_(3)-SnO_(2)nanoflake arrays were synthesized on fluorine-doped tin oxide(FTO)by hydrothermal synthesis and pulse electrodeposition,revealing significant surface-enhanced Raman scattering(SERS)activity with an enhancement factor(EF)reaching 4.79×10^(7).The obvious EF was mainly ascribed to the charge transfer between WO_(3)-SnO_(2)and methylene blue(MB)based on chemical mechanism(CM)and the molecular resonance effect.With the competitive adsorption of DA and absorbed MB,we prepared a SERS and electrochemical(EC)dual-mode detection platform of DA based on the WO_(3)-SnO_(2)nanoflake arrays.The linear range(LR)was 5.00-1.75×10^(3)nmol/L,and the detection limits(LODs)were as low as 1.50 and 0.80 nmol/L by SERS and EC respectively.Besides,the developed detection platform can shield the interference of many neurotransmitters similar to DA,showing good selectivity and excellent stability.In general,the SERS-EC dual-mode detection platform can be well applied to the detection of DA in cell lysate,demonstrating great potential in diagnosis of neurodegenerative diseases.

关键词： surface enhanced Raman scattering electrochemical WO3-SnO2 nanoflake arrays charge transfer Dopamine

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Pramipexole, a Dopamine D3/D2 receptor-preferring agonist, attenuates reserpine-induced fibromyalgia-like model in mice

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Neural Regeneration Research 2022年第2期17卷 450-458页

作者： Carlos Pereira Martins Rodrigo Sebben Paes Gabriela Mantovani Baldasso Eduarda Gomes Ferrarini Rahisa Scussel Rubya Pereira Zaccaron Ricardo Andrez Machado-de-Avila Paulo Cesar Lock Silveira Rafael Cypriano Dutra Laboratory of Autoimmunity and Immunopharmacology Department of Health SciencesCampus AraranguaUniversidade Federal de Santa CatarinaAraranguáSCBrazil Post-Graduate Program of Neuroscience Center of Biological SciencesUniversidade Federal de Santa CatarinaFlorianópolisSCBrazil Laboratory of Experimental Physiopathology Program of Postgraduate in Science of HealthUniversidade do Extremo Sul CatarinenseCriciumaSCBrazil

Fibromyalgia(FM) is a complex pathology described as persistent hyperalgesia including somatic and mood dysfunctions, depression and anxiety. Although the etiology of FM is still unknown, a significant decrease in biogenic amines is a common characteristic in its pathogenesis. Here, our main objective was to investigate the role of Dopamine D3/D2 receptor during the reserpine-induced pain in mice. Our results showed that pramipexole(PPX) – a Dopaminergic D3/D2 receptor agonist – inhibited mechanical allodynia and thermal sensitivity induced by reserpine. Relevantly, PPX treatment decreased immobility time and increased the number of grooming in the forced swimming test and splash test, respectively. Animals that received PPX remained longer in the open arms than the reserpine group using elevated plusmaze apparatus. The repeated PPX administration, given daily for 4 days, significantly blocked the mechanical and thermal allodynia during FM model, similarly to pregabalin, although it failed to affect the reserpine-induced thermal nociception. Reserpine administration induced significant downregulation of Dopamine concentration in the central nervous system, and repeated treatment with PPX restored Dopamine levels in the frontal cortex and spinal cord tissues. Moreover, PPX treatment inhibited oxidants production such as DCFH(2′,7′-dichlorodihydrofluorescein) and nitrite, also decreased oxidative damage(carbonyl), and upregulated the activity of superoxide dismutase in the spinal cord. Together, our findings demonstrated the ability of Dopamine D3/D2 receptor-preferring agonist in reducing pain and mood dysfunction allied to FM in mice. All experimental protocols were approved by the Universidade Federal de Santa Catarina(UFSC) Ethics Committee(approval No. 2572210218) on May 10, 2018.

关键词： Dopamine Dopaminergic system fibromyalgia hyperalgesia pain pramipexole reserpine

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Nitrogen-doped carbon@TiO_(2) double-shelled hollow spheres as an electrochemical sensor for simultaneous determination of Dopamine and paracetamol in human serum and saliva

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Journal of Pharmaceutical Analysis 2022年第3期12卷 436-445页

作者： Hui Yang Gongxun Cao Yongjun Huang Ye Lin Fengying Zheng Luxiu Lin Fengjiao Liu Shunxing Li College of Chemistry Chemical Engineering and EnvironmentMinnan Normal UniversityZhangzhouFujian363000China Fujian Provincial Key Laboratory of Pollution Monitoring and Control Minnan Normal UniversityZhangzhouFujian363000China Fujian Key Laboratory of Separation and Analysis Science and Technology ZhangzhouFujian363000China

As the most commonly used antipyretic and analgesic drug,paracetamol(PA)coexists with neurotransmitter Dopamine(DA)in real biological samples.Their simultaneous determination is extremely important for human health,but they also interfere with each other.In order to improve the conductivity,adsorption affinity,sensitivity,and selectivity of TiO_(2)-based electrochemical sensor,N-doped carbon@-TiO_(2) double-shelled hollow sphere(HeC/N@TiO_(2))is designed and synthesized by simple alcoholic and hydrothermal method,using polystyrene sphere(PS)as a template.Meanwhile,TiO_(2) hollow spheres(H eTiO_(2))or N-doped carbon hollow spheres(HeC/N)are also prepared by the same method.HeC/N@TiO_(2) has good conductivity,charge separation,and the highly enhanced and stable current responses for the detection of PA and DA.The detection limit and linear range are 50.0 nmol/L and 0.3-50 mmol/L for PA,40.0 nmol/L and 0.3e50 mmol/L for DA,respectively,which are better than those of carbon-based sensors.Moreover,this electrochemical sensor,with high selectivity,strong anti-interference,high reliability,and long time durability,can be used for the simultaneous detection of PA and DA in human blood serum and saliva.The high electrochemical performance of HeC/N@TiO_(2) is attributed to the multifunctional combination of different layers,because of good conductivity,absorption and electrons transfer ability from in-situ N-doped carbon and electrocatalytic activity from TiO_(2).

关键词： Electrochemical sensor Simultaneous determination Paracetamol Dopamine

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Diabetes mellitus and Parkinson's disease:dangerous liaisons between insulin and Dopamine

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Neural Regeneration Research 2022年第3期17卷 523-533页

作者： Angela De Iuliis Ennio Montinaro Giuseppe Fatati Mario Plebani Carlo Colosimo Department of Medicine-DiMED University of PadovaItaly Department of Neurology Santa Maria University HospitalTerniItaly Italian Obesity Network TerniItaly Department of Medicine-DiMED University of PadovaPadovaItaly/Department of Laboratory Medicine-Hospital of PadovaPadovaItaly

The relationship between diabetes mellitus and Parkinson's disease has been described in several epidemiological studies over the 1960 s to date.Molecular studies have shown the possible functional link between insulin and Dopamine,as there is strong evidence demonstrating the action of Dopamine in pancreatic islets,as well as the insulin effects on feeding and cognition through central nervous system mechanism,largely independent of glucose utilization.Therapies used for the treatment of type 2 diabetes mellitus appear to be promising candidates for symptomatic and/or disease-modifying action in neurodegenerative diseases including Parkinson's disease,while an old Dopamine agonist,bromocriptine,has been repositioned for the type 2 diabetes mellitus treatment.This review will aim at reappraising the different studies that have highlighted the dangerous liaisons between diabetes mellitus and Parkinson's disease.

关键词： Dopamine GLP-1 insulin Parkinson's disease type 2 diabetes mellitus

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Altered Retinal Dopamine Levels in a Melatonin-proficient Mouse Model of Form-deprivation Myopia

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Neuroscience Bulletin 2022年第9期38卷 992-1006页

作者： Kang-Wei Qian Yun-Yun Li Xiao-Hua Wu Xue Gong Ai-Lin Liu Wen-Hao Chen Zhe Yang Ling-Jie Cui Yun-Feng Liu Yuan-Yuan Ma Chen-Xi Yu Furong Huang Qiongsi Wang Xiangtian Zhou Jia Qu Yong-Mei Zhong Xiong-Li Yang Shi-Jun Weng State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain ScienceFudan UniversityShanghai200032China Discipline of Neuroscience and Department of Anatomy and Physiology College of Basic Medical SciencesShanghai Jiao Tong University School of MedicineShanghai200025China School of Ophthalmology and Optometry and Eye Hospital Wenzhou Medical UniversityWenzhou325027China Department of Immunology School of Basic Medical SciencesAnhui Medical UniversityHefei230032China

Reduced levels of retinal Dopamine,a key regulator of eye development,are associated with experimental myopia in various species,but are not seen in the myopic eyes of C57BL/6 mice,which are deficient in melatonin,a neurohormone having extensive interactions with Dopamine.Here,we examined the relationship between form-deprivation myopia(FDM)and retinal Dopamine levels in melatonin-proficient CBA/CaJ mice.We found that these mice exhibited a myopic refractive shift in form-deprived eyes,which was accompanied by altered retinal Dopamine levels.When melatonin receptors were pharmacologically blocked,FDM could still be induced,but its magnitude was reduced,and retinal Dopamine levels were no longer altered in FDM animals,indicating that melatonin-related changes in retinal Dopamine levels contribute to FDM.Thus,FDM is mediated by both Dopamine level-independent and melatonin-related Dopamine level-dependent mechanisms in CBA/CaJ mice.The previously reported unaltered retinal Dopamine levels in myopic C57BL/6 mice may be attributed to melatonin deficiency.

关键词： Myopia Refractive development Dopamine Melatonin Mouse Retina

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Dopamine Control of REM Sleep and Cataplexy

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Neuroscience Bulletin 2022年第12期38卷 1617-1619页

作者： Chujun Zhang Luyan Huang Min Xu Institute of Neuroscience State Key Laboratory of NeuroscienceCenter for Excellence in Brain Science and Intelligence TechnologyChinese Academy of SciencesShanghai 200031China Shanghai Jiao Tong University School of Medicine Afliated Sixth People’s Hospital Shanghai 200233China Shanghai Key Laboratory of Sleep Disordered Breathing Shanghai 200233China

The brain circuits underlying sleep-wake regulation are not fully understood,although significant progress has been made in the past few decades[1-3].Different sleep-wake states arecontrolledbydistinct neural circuits.

关键词： Dopamine sleep neural

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Characterization and application of a recombinant dopa decarboxylase from Harmonia axyridis for the efficient biosynthesis of Dopamine

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Chinese Journal of Chemical Engineering 2022年第1期35卷 449-456页

作者： Siyuan Gao Yuanke Guo Chen Ma Ding Ma Kequan Chen Pingkai Ouyang Xin Wang State Key Laboratory of Materials-Oriented Chemical Engineering College of Biotechnology and Pharmaceutical EngineeringNanjing Tech UniversityNanjing 211816China

Here,a dopa decarboxylase(DDC)from Harmonia axyridis was heterogeneously expressed in Escherichia coli for the efficient biosynthesis of Dopamine.For the production of recombinant DDC,the cultivation conditions including IPTG concentration,temperature and induction time were optimized and obtained an optimal specific enzyme activity of 51.72 U·mg^(-1) crude extracts.After the purification of DDC with a recovery yield of 68.79%,its activity was further characterized.The Vmax,Km,Kcat,and Kcat/Km of DDC for d ihyd roxy pheny la la nine(dopa)were 0.02 mmol·ml^(-1)·s^(-1),2.328 mmol·ml^(-1),10435.90 s^(-1) and4482.77 ml,mmol respectively.The highest DDC activity was observed at the condition of pH 7.5 and 45℃.With the purified DDC,the feasibility to produce Dopamine from L-dopa was evaluated.The optimal yield was determined at the following bioconversion conditions:pH of 7,0,the reaction temperature of 40℃,0.4 mmol·L^(-1) of PLP and 4 g·L^(-1) of L-dopa,Subsequently,a fed-batch process for the production of Dopamine was developed and the effect of oxygen was evaluated.The titer,yield and productivity of Dopamine reached up to 21.99 g·L^(-1)80.88%and 14.66 g·L^(-1)·h^(-1) at 90 min under anaerobic condition.

关键词： Dopa decarboxylase Dopamine Enzyme catalysis Fed-batch bioconversion

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Diatomic active sites nanozymes:Enhanced peroxidase-like activity for Dopamine and intracellular H2O2 detection

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Nano Research 2022年第5期15卷 4266-4273页

作者： Shan Wang Zunfu Hu Qiulian Wei Huimin Zhang Weina Tang Yunqiang Sun Haiqiang Duan Zhichao Dai Qingyun Liu Xiuwen Zheng Key Laboratory of Functional Nanomaterials and Technology in Universities of Shandong College of Chemistry and Chemical EngineeringLinyi UniversityLinyi 276000China School of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266510China School of Materials Science and Engineering Linyi UniversityLinyi 276000China

Considering intracellular hydrogen peroxide(H_(2)O_(2))plays pivotal roles in the regulation of serial biological processes,the in-situ detection of intracellular H2O2 has attracted an extensive attention.In the present work,an atomically dispersed diatomic active sites Nanozymes(FeN_(3)/PtN_(4)-single-atom nanozymes(SAzyme))was prepared exhibiting enhanced peroxidase-like activity.The obvious synergistic effect between Fe-Pt heteronuclear diatomic active sites was confirmed by series of characterization and density functional theory(DFT).The peroxidase-like activity of Fe-sites could be substantially enhanced by the bonded Pt-sites via the modulation effect.As a consequence,the gap between the d-band centre(εd)of Fe 3d orbitals and the Fermi energy level was narrowed and the electronic interaction could be strengthened,leading to a lower free energy barrier and a lower activation energy as well as fortified metal-O bonding in the kinetic pathway.Therefore,the constructed FeN3/PtN4-SAzyme exhibited higher peroxidase-like activity than that of FeN4-SAzyme.The FeN3/PtN4-SAzyme-assisted oxidation of 3,3',5,5'-tetramethylbenzidine(TMB)facilitated the colorimetric detection of Dopamine(DA),an important biomolecule.The linear detection range and limit of detection(LOD)of DA and H_(2)O_(2) were 1-10 μM,0.01-1.0 mM and 0.109 μM,7.97 μM,respectively.In addition,the constructed SAzymes were also applied for the in-situ detection of intracellular H2O2,expanding the application scope of the newborn SAzymes.

关键词： single-atom nanozymes heteronuclear diatomic active sites peroxidase-like Dopamine intracellular H_(2)O_(2)

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Flexible and ultrathin Dopamine modified MXene and cellulose nanofiber composite films with alternating multilayer structure for superior electromagnetic interference shielding performance

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Frontiers of physics 2023年第3期18卷 155-166页

作者： Qiugang Liao Hao Liu Ziqiang Chen Yinggan Zhang Rui Xiong Zhou Cui Cuilian Wen Baisheng Sa Multiscale Computational Materials Facility and Key Laboratory of Eco-materials Advanced TechnologyCollege of Materials Science and EngineeringFuzhou UniversityFuzhou 350100China College of Materials Fujian Provincial Key Laboratory of Theoretical and Computational ChemistryXiamen UniversityXiamen 361005China

With the development of modern electronics,especially the next generation of wearable electromagnetic interference(EMI)shielding materials requires flexibility,ultrathin,lightweight and robustness to protect electronic devices from radiation pollution.In this work,the flexible and ultrathin Dopamine modified MXene@cellulose nanofiber(DM@CNF)composite films with alternate multilayer structure have been developed by a facile vacuum filtration induced self-assembly approach.The multilayered DM@CNF composite films exhibit improved mechanical properties compared with the homogeneous DM/CNF film.By adjusting the layer number,the multilayered DM3@CNF2 composite film exhibits a tensile strength of 48.14 MPa and a toughness of 5.28 MJ·m^(–3) with a thickness about 19μm.Interestingly that,the DM@CNF film with annealing treatment achieves significant improvement in conductivity(up to 17264 S·m^(–1))and EMI properties(SE of 41.90 dB and SSE/t of 10169 dB·cm^(2)·g–1),which still maintains relatively high mechanical properties.It is highlighted that the ultrathin multilayered DM@CNF film exhibits superior EMI shielding performance compared with most of the metal-based,carbon-based and MXene-based shielding materials reported in the literature.These results will offer an appealing strategy to develop the ultrathin and flexible MXene-based materials with excellent EMI shielding performance for the next generation intelligent protection devices.

关键词： MXene Dopamine cellulose nanofibers electromagnetic interference shielding performance mechanical properties

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