Diabetes mellitus and Parkinson's disease:dangerous liaisons between insulin and dopamine

作     者：Angela De Iuliis Ennio Montinaro Giuseppe Fatati Mario Plebani Carlo Colosimo Angela De Iuliis;Ennio Montinaro;Giuseppe Fatati;Mario Plebani;Carlo Colosimo

作者机构：Department of Medicine-DiMEDUniversity of PadovaItaly Department of NeurologySanta Maria University HospitalTerniItaly Italian Obesity NetworkTerniItaly Department of Medicine-DiMEDUniversity of PadovaPadovaItaly/Department of Laboratory Medicine-Hospital of PadovaPadovaItaly 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2022年第17卷第3期

页      面：523-533页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学] 

主　　题：dopamine GLP-1 insulin Parkinson's disease type 2 diabetes mellitus 

摘      要：The relationship between diabetes mellitus and Parkinson s disease has been described in several epidemiological studies over the 1960 s to date.Molecular studies have shown the possible functional link between insulin and dopamine,as there is strong evidence demonstrating the action of dopamine in pancreatic islets,as well as the insulin effects on feeding and cognition through central nervous system mechanism,largely independent of glucose utilization.Therapies used for the treatment of type 2 diabetes mellitus appear to be promising candidates for symptomatic and/or disease-modifying action in neurodegenerative diseases including Parkinson s disease,while an old dopamine agonist,bromocriptine,has been repositioned for the type 2 diabetes mellitus treatment.This review will aim at reappraising the different studies that have highlighted the dangerous liaisons between diabetes mellitus and Parkinson s disease.