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Pathogenesis,disease course,and prognosis of adult-onset Still’s disease:an update and review

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Chinese Medical Journal 2019年第23期132卷 2856-2864页

作者： Meng-Yan Wang Jin-Chao Jia Cheng-De Yang Qiong-Yi Hu Department of Rheumatology and Immunology Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China

Objective:Adult-onset Still's disease(AOSD)is a rare but clinically well-known polygenic systemic autoinflammatory *** this review,we aim to present frontiers in the pathogenesis,clinical features,diagnosis,biomarkers,disease course,prognosis,and treatment in *** sources:We retrieved information from the PubMed database up to July 2019,using various search terms and relevant words,including AOSD and Still's *** selection:We included data from peer-reviewed *** basic and clinical studies were ***:Pathogenesis of AOSD involves genetic background,infectious triggers,and immunopathogenesis,mainly the activation of macrophages and neutrophils followed by a cytokine *** and prognosis evaluation of AOSD is still challenging;therefore,there is an urgent need to identify better *** agents,including interleukin(IL)-ip,IL-6,and tumor necrosis factor-a antagonists in the treatment of AOSD,have good ***:This review highlights the advances in pathogenesis,potential biomarkers,disease course,and treatment in AOSD.

关键词： Adult-onset StilPs disease Biomarkers disease course Pathogenesis Treatment

Prediction of disease course in inflammatory bowel diseases

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World Journal of Gastroenterology 2010年第21期16卷 2589-2590页

作者： Peter Laszlo Lakatos 1st Department of Medicine Semmelweis UniversityH-1083 BudapestKoranyi S 2AHungary

Clinical presentation at diagnosis and disease course of both Crohn's disease(CD) and ulcerative colitis are heterogeneous and variable over *** most patients have a relapsing course and most CD patients develop complications(*** and/or perforation),much emphasis has been placed in the recent years on the determination of important predictive *** identification of these factors may eventually lead to a more personalized,tailored *** this TOPIC HIGHLIGHT series,we provide an update on the available literature regarding important clinical,endoscopic,fecal,serological/routine laboratory and genetic *** aim is to assist clinicians in the everyday practical decisionmaking when choosing the treatment strategy for their patients suffering from inflammatory bowel diseases.

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis disease course Predictive markers Clinical Serology Genetics

Albumin as a prognostic marker for ulcerative colitis

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World Journal of Gastroenterology 2017年第45期23卷 8008-8016页

作者： Nabeel Khan Dhruvan Patel Yash Shah Chinmay Trivedi Yu-Xiao Yang Section of Gastroenterology University of Pennsylvania Perelman School of Medicine Section of Gastroenterology Corporal Michael J. Crescenz VA Medical Center Department of Gastroenterology Drexel University College of Medicine Department of Internal Medicine Icahn School of Medicine at Mount SinaiJames J. Peters VA Medical Center

AIM To evaluate the role of albumin at the time of ulcerative colitis(UC) diagnosis in predicting the clinical course of *** Nationwide cohort of patients with newly diagnosed UC in the Veterans Affairs health care system was identified and divided into two categories: hypoalbuminemia(i.e.,≤ 3.5 gm/dl) or normal albumin levels(i.e.,> 3.5 gm/dl) at the time of UC diagnosis. The exposure of interest was presence of hypoalbuminemia defined asalbumin level ≤ 3.5 g/dl at the time of UC diagnosis. Patients were then followed over time to identify the use of ≥ 2 courses of corticosteroids(CS),thiopurines,anti-TNF medications and requirement of colectomy for UC management. RESULTS The eligible study cohort included 802 patients,but 92(11.4%) patients did not have their albumin levels checked at the time of UC diagnosis,and they were excluded. A total of 710 patients,who had albumin levels checked at time of UC diagnosis,were included in our study. Amongst them,536 patients had a normal albumin level and 174 patients had hypoalbuminemia. Patients with hypoalbuminemia at diagnosis had a higher likelihood of ≥ 2 courses of CS use(adjusted HR = 1.7,95%CI: 1.3-2.3),higher likelihood of thiopurine or anti-TNF use(adjusted HR = 1.72,95%CI: 1.23-2.40) than patients with normal albumin level at diagnosis. There was a trend of higher likelihood of colectomy in hypoalbuminemic patients,but it was not statistically significant(Adjusted HR = 1.7,95%CI: 0.90-3.25).CONCLUSION Hypoalbuminemia at disease diagnosis can serve as a prognostic marker to predict the clinical course of UC at the time of diagnosis.

关键词： Prognostic marker Albumin Ulcerative colitis disease course Colectomy

Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第2期7卷 235-241页

作者： Magnus Hofrenning Wanderas Bjorn A Moum Marte Lie Hoivik Oistein Hovde Department of Medicine Innlandet Hospital Trust Faculty of Medicine University of Oslo Department of Gastroen-terology Oslo University Hospital Institute of Clinical Medicine University of Oslo Department of Gastroenterology Innlandet Hospital Trust

Ulcerative colitis(UC)is characterized by chronic inflammation of the large bowel in genetically suscep-tible individuals exposed to environmental risk *** disease course can be difficult to predict,with symptoms ranging from mild to *** is no generally accepted definition of severe UC,and no single outcome is sufficient to classify a disease course as *** are several outcomes indicating a severe disease course,including progression of the disease’s extension,a high relapse rate,the development of acute severe colitis,colectomy,the occurrence of colorectal cancer and UC-related *** evaluating a patient’s prognosis,it is helpful to do so in relation to these *** these outcomes also makes it easier to isolate factors predictive of severe *** aims of this article are to evaluate different disease outcomes and to present predictive factors for these outcomes.

关键词： Ulcerative colitis disease course Prognosis Severity Colectomy Relapse Acute severe colitis Cancer Mortality

Precision medicine in inflammatory bowel disease

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Precision Clinical Medicine 2024年第1期7卷 54-80页

作者： Zhen Zeng Mingshan Jiang Xi Li Jing Yuan Hu Zhang Department of Gastroenterology West China HospitalSichuan UniversityChengdu 610041China Centrefor Inflammatory Bowel disease West China HospitalSichuan UniversityChengdu 610041China Lab of Inflammatory Bowel disease Frontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China General Practice Ward/International Medical Center Ward General Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041China

Inflammatory bowel disease(IBD)is an incurable disease characterized by remission-relapse cycles throughout its *** Crohn's disease(CD)and ulcerative colitis(UC),the two main forms of IBD,exhibit tendency to develop complications and substantial heterogeneity in terms of frequency and severity of relapse,thus posing great challenges to the clinical management for *** treatment strategies are effective in different ways in induction and maintenance therapies for *** advances in studies of genetics,pharmacogenetics,proteomics and microbiome provide a strong driving force for identifying molecular markers of prognosis and treatment response,which should help clinicians manage IBD patients more effectively,and then,improve clinical outcomes and reduce treatment costs of *** this review,we summarize and discuss precision medicine in IBD,focusing on predictive markers of disease course and treatment response,and monitoring indices during therapeutic drug monitoring.

关键词： disease course inflammatory bowel disease precision treatment precision monitoring treatment response

球后脂肪体积测定对甲状腺相关性眼病治疗时机的判定价值

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南方医科大学学报 2017年第5期37卷 640-645页

作者：蒋薇蔡秋月李章芳陈智毅罗耀升胡世弟沈洁南方医科大学第三附属医院内分泌与代谢科广东广州510630

目的探讨商业化软件计算球后脂肪体积,分析其与甲状腺相关性眼病(TAO)进展及预后的关系。方法收集2016年1月~2016年12月在我院内分泌科确诊的35例(70个眼眶)TAO患者的临床资料。测量1.5T眼眶MRI球后脂肪体积及眼外肌信号强度比值(SIR)... 详细信息

目的探讨商业化软件计算球后脂肪体积,分析其与甲状腺相关性眼病(TAO)进展及预后的关系。方法收集2016年1月~2016年12月在我院内分泌科确诊的35例(70个眼眶)TAO患者的临床资料。测量1.5T眼眶MRI球后脂肪体积及眼外肌信号强度比值(SIR)分析其与临床各项指标的相关性,并收集12例(24个眼眶)健康人测量球后脂肪体积,初步比较TAO组及健康组体积的差异。结果脂肪体积与病程成正相关(r=0.480,P<0.01),病程6个月以内组与6~12个月组相比,脂肪体积差异不显著(P=0.084)。病程6个月以内组及病程6~12个月组球后脂肪体积均显著低于病程大于12个月组(P<0.01,P<0.05)。脂肪体积与突眼度存在相关性(r=0.622,P<0.01),突眼度每增加1 mm,球后脂肪体积将增加0.88 m L。临床活动性评分(CAS)与SIR值及促甲状腺素受体抗体(TRAb)存在相关性(r=0.536,r=0.416,P<0.01)。TAO组球后脂肪体积显著高于正常组(P<0.01)。结论 TAO病程1年以上可能是球后脂肪组织增多的高峰阶段,球后脂肪体积结合SIR值的测量有助于最佳激素治疗时机的探索及预后分析。

关键词： thyroid-associated ophthalmopathy exophthalmos orbital magnetic resonance imaging orbital fat volume disease course