Predictive factors for a severe clinical course in ulcerative colitis: Results from population-based studies

作     者：Magnus Hofrenning Wanderas Bjorn A Moum Marte Lie Hoivik Oistein Hovde 

作者机构：Department of MedicineInnlandet Hospital Trust Faculty of MedicineUniversity of Oslo Department of Gastroen-terologyOslo University Hospital Institute of Clinical MedicineUniversity of Oslo Department of GastroenterologyInnlandet Hospital Trust 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2016年第7卷第2期

页      面：235-241页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Ulcerative colitis Disease course Prognosis Severity Colectomy Relapse Acute severe colitis Cancer Mortality 

摘      要：Ulcerative colitis(UC)is characterized by chronic inflammation of the large bowel in genetically suscep-tible individuals exposed to environmental risk *** disease course can be difficult to predict,with symptoms ranging from mild to *** is no generally accepted definition of severe UC,and no single outcome is sufficient to classify a disease course as *** are several outcomes indicating a severe disease course,including progression of the disease’s extension,a high relapse rate,the development of acute severe colitis,colectomy,the occurrence of colorectal cancer and UC-related *** evaluating a patient’s prognosis,it is helpful to do so in relation to these *** these outcomes also makes it easier to isolate factors predictive of severe *** aims of this article are to evaluate different disease outcomes and to present predictive factors for these outcomes.