Precision medicine in inflammatory bowel disease
作者机构：Department of GastroenterologyWest China HospitalSichuan UniversityChengdu 610041China Centrefor Inflammatory Bowel DiseaseWest China HospitalSichuan UniversityChengdu 610041China Lab of Inflammatory Bowel DiseaseFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengdu 610041China General Practice Ward/International Medical Center WardGeneral Practice Medical CenterWest China HospitalSichuan UniversityChengdu 610041China
出 版 物：《Precision Clinical Medicine》 (精准临床医学（英文）)
年 卷 期：2024年第7卷第1期
页 面：54-80页
学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported in part by the Sichuan International Science and Technology Innovation Cooperation/Hong Kong/Macao/Taiwan Science and Technology Innovation Cooperation Project (Grant No.2021YFH0189) the Sichuan International Science Foundation Project (Grant No.2022NSFSC1363) the project for disciplines of excellence-Clinical Research Incubation Project,West China Hospital,Sichuan University (Grant No.2021HXFH065)
主 题：disease course inflammatory bowel disease precision treatment precision monitoring treatment response
摘 要：Inflammatory bowel disease(IBD)is an incurable disease characterized by remission-relapse cycles throughout its *** Crohn s disease(CD)and ulcerative colitis(UC),the two main forms of IBD,exhibit tendency to develop complications and substantial heterogeneity in terms of frequency and severity of relapse,thus posing great challenges to the clinical management for *** treatment strategies are effective in different ways in induction and maintenance therapies for *** advances in studies of genetics,pharmacogenetics,proteomics and microbiome provide a strong driving force for identifying molecular markers of prognosis and treatment response,which should help clinicians manage IBD patients more effectively,and then,improve clinical outcomes and reduce treatment costs of *** this review,we summarize and discuss precision medicine in IBD,focusing on predictive markers of disease course and treatment response,and monitoring indices during therapeutic drug monitoring.
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