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Analysis of influencing factors and interaction of body weight and disease outcome in patients with prediabetes

World Journal of Diabetes 2023年第10期14卷 1551-1561页

作者： Yan-Yan Li Lin-Ping Tong Xian-Dan Wu Dan Lin Yue Lin Xiao-Yang Lin Department of General Practice The First People’s Hospital of Wenling CityWenling 317500Zhejiang ProvinceChina Department of Oncology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200437China Department of General Medicine The First People’s Hospital of Wenling CityWenling 317500Zhejiang ProvinceChina

BACKGROUND The trend of prediabetes progressing to type 2 diabetes mellitus(T2DM)is prominent,and effective intervention can lead to a return to *** the factors influencing the outcome of prediabetes is helpful to guide clinical *** weight change in patients with prediabetes has not attracted much *** To explore the interaction between body weight and the factors affecting the progression of prediabetes to *** We performed a retrospective analysis of 236 patients with prediabetes and 50 with normal glucose tolerance(NGT),and collected clinical data and follow-up results of all *** on natural blood glucose outcomes,we classified 66 patients with progression to T2DM into the disease progression(DP)group,and 170 patients without progression to T2DM into the disease outcome(DO)*** analyzed the factors that influenced prediabetes outcome and the influence of body weight on prediabetes blood glucose outcome by unconditional logistic regression.A general linear model(univariate)was used to analyze the interaction between body weight and independent influencing *** There were 98 cases of impaired fasting glucose(IFG),90 cases of impaired glucose tolerance(IGT),and 48 cases of coexistent IFG and *** body weight,waist circumference,body mass index,fasting blood glucose,and 2 h plasma glucose of patients with IFG,IGT,and coexistent IFG and IGT were higher than those in patients with NGT(P<0.05).Logistic regression analysis showed that body weight,glycosylated hemoglobin,uric acid,fasting insulin,and homeostatic model assessment for insulin resistance were independent factors affecting progression of prediabetes to T2DM(P<0.05).Receiver operating characteristic curve analysis showed that the area under the curve predicted by the above indicators combined was 0.905[95%confidence interval(CI):0.863-0.948],which was greater than that predicted by each indicator *** regression analysis with

关键词： Prediabetes Type 2 diabetes mellitus Body weight disease outcome Influencing factors Interactions Lowcarbohydrate diet

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Analysis of factors associated with disease outcomes in hospitalized patients with 2019 novel coronavirus disease

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Chinese Medical Journal 2020年第9期133卷 1032-1038页

作者： Wei Liu Zhao-Wu Tao Lei Wang Ming-Li Yuan Kui Liu Ling Zhou Shuang Wei Yan Deng Jing Liu Hui-Guo Liu Ming Yang Yi Hu Department of Respiratory and Critical Care Medicine The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014China Department of Respiratory Intensive Care Unit The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014China Department of Respiratory and Critical Care Medicine Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China Department of Radiology Wuhan Pulmonary HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China The Provost’s Office The Central Hospital of WuhanTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430014China

Background Since early December 2019,the 2019 novel coronavirus disease(COVID-19)has caused pneumonia epidemic in Wuhan,Hubei province of *** study aimed to investigate the factors affecting the progression of pneumonia in COVID-19 *** results will be used to evaluate the prognosis and to find the optimal treatment regimens for COVID-19 *** Patients tested positive for the COVID-19 based on nucleic acid detection were included in this *** were admitted to 3 tertiary hospitals in Wuhan between December 30,2019,and January 15,*** data,laboratory indices,imaging characteristics,and clinical data were collected,and statistical analysis was *** on clinical typing results,the patients were divided into a progression group or an improvement/stabilization *** variables were analyzed using independent samples t-test or Mann-Whitney U *** variables were analyzed using Chi-squared test or Fisher’s exact *** regression analysis was performed to explore the risk factors for disease *** Seventy-eight patients with COVID-19-induced pneumonia met the inclusion criteria and were included in this *** evaluation at 2 weeks after hospitalization indicated that 11 patients(14.1%)had deteriorated,and 67 patients(85.9%)had improved/*** patients in the progression group were significantly older than those in the disease improvement/stabilization group(66[51,70]vs.37[32,41]years,U=4.932,P=0.001).The progression group had a significantly higher proportion of patients with a history of smoking than the improvement/stabilization group(27.3%vs.3.0%,χ^2=9.291,P=0.018).For all the 78 patients,fever was the most common initial symptom,and the maximum body temperature at admission was significantly higher in the progression group than in the improvement/stabilization group(38.2[37.8,38.6]vs.37.5[37.0,38.4]°C,U=2.057,P=0.027).Moreover,the proportion of pat

关键词： 2019 Novel coronavirus disease disease outcome Predictors

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Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 556-563页

作者： Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless Department of Medicine Division of Gastroenterology and HepatologyJohns Hopkins University Guangdong provincial Key Laboratory of Colorectal and Pelvic Floor diseases the Sixth Affiliated Hospital of Sun Yat-sen University Department of Gastroenterology the Sixth Affiliated Hospital of Sun Yat-sen University Department of Medicine Med Star Health Internal Medicine Department of Health and Sport Sciences Federal University of Acre Department of Medicine Faculty of Medicine and Health SciencesAn-Najah National University Ravindra Nath Tagore Medical College St Vincent Hospital Department of Epidemiology Johns Hopkins University Bloomberg School of Public Health

AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn's disease(CD) residing in China and the United *** We performed a survey-based cross-sectional study of participants with CD recruited from China and the United *** compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential *** We recruited 49 participants from China and 145 from the United *** prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in *** involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two *** The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United *** the potential difference in etiology,surgery and ileal involvement were similar in the two *** the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.

关键词： Crohn’s disease Family history disease outcome Inflammatory bowel disease Epidemiology genetics Environment Medication Surgery

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Clinical Analysis of 128 Children and Adolescents with Echinococcosis

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Proceedings of Anticancer Research 2024年第1期8卷 1-9页

作者： Linghong Zhu Yanqing Ma Yongmei Lan Zilong Zhang Northwest Minzu University Lanzhou 730030Gansu ProvinceChina Department of Science and Education Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina Department of Oncosurgery Qinghai Provincial People’s HospitalXining 810007Qinghai ProvinceChina

Objective:To comprehend the clinical characteristics and treatment approaches for children and adolescents in Qinghai Province with two types of echinococcosis,cystic echinococcosis(CE)and alveolar echinococcosis(AE).Methods:A total of 128 pediatric inpatients with echinococcosis at the People’s Hospital of Qinghai Province and the Clinical Research Institute of Echinococcosis of Qinghai Province between January 2016 and December 2021 were chosen as *** and clinical data were collected,and double data entry was executed using EpiData *** influencing the cure of echinococcosis were analyzed with echinococcosis cure as the dependent variable,employing statistical analysis via SPSS ***:Of the cases,35.9%had CE,and 64.1%had *** types were observed in patients of all ages,with the majority aged *** number of cysts and their sizes varied between CE and *** were prevalent,including liver,gallbladder,lung,and nutritional *** analyses revealed significant differences in outcomes based on factors such as cyst size(for CE),liver function grade(for AE),hydatid hypersensitivity test,operation,and length of hospital stay(P<0.05).Conclusion:This comprehensive analysis of hospitalized cases sheds light on the clinical data of echinococcosis in children and adolescents in Qinghai *** findings contribute to a scientific foundation for formulating effective prevention and control measures tailored to this demographic,facilitating an improved understanding of echinococcosis in Qinghai province.

关键词： Echinococcosis Children and adolescents Clinical features disease outcome

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Cyclooxygenase-2 expression as a predictor of outcome in colorectal carcinoma

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World Journal of Gastroenterology 2012年第15期18卷 1793-1799页

作者： Jaudah Al-Maghrabi Abdelbaset Buhmeida Eman Emam Kari Syrjnen Abdulrahman Sibiany Mohmmad Al-Qahtani Mahmoud Al-Ahwal Department of Pathology King Abdulaziz UniversityJeddah 21589Saudi Arabia Center of Excellence in Genomic Medicine Research King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Oncology and Radiotherapy Turku University HospitalT-Hospital(Administration)FIN20521 TurkuFinland Department of Surgery King Abdulaziz UniversityJeddah 21589Saudi Arabia Department of Medicine Scientific Chair for Colorectal CancerKing Abdulaziz UniversityJeddah 21589Saudi Arabia

AIM:To correlate cyclooxygenase-2(COX-2)expression profile with clinical and pathological variables to assess their prognostic/predictive value in colorectal carcinoma(CRC).METHODS:Archival tumor samples were analyzed using immunohistochemistry for COX-2 expression in 94 patients with *** were diagnosed and treatedat the Departments of Surgery and Oncology,King Abdulaziz University Hospital,Saudi ***:Fifty-six percent of the tumors showed positive cytoplasmic COX-2 expression,whereas 44%of cases were completely *** were no significant correlations between COX-2 expression and sex,age,grade or tumor ***,COX-2 expression revealed a significant correlation with tumor stage(P=0.01)and distant metastasis(P=0.02),and a borderline association with lymph node involvement(P =0.07).Tumors with high COX-2 expression showed a higher recurrence rate than tumors with no expression(Pdisease-free survival between COX-2-positive and negative tumors in favor of the ***-2 expression did not significantly predict disease-specific survival,which was much shorter for COX-2-positive *** multivariate(COX)models,COX-2 did not appear among the independent predictors of disease-free survival or disease-specific ***:COX-2 expression seems to provide useful prognostic information in CRC,while predicting the patients at high risk for recurrent disease.

关键词： Colorectal carcinoma Cyclooxygenase-2 Immunohistochemistry disease outcome Adjuvant therapy

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P─GLYCOPROTEIN EXPRESSION IN PRIMARY BREAST CANCER

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Chinese Medical Sciences Journal 1995年第1期10卷 12-15页

作者：何洛文郝纯毅林本耀王怡高非 Beijing Institute for Cancer Research Beijing Medical University College of Clinical Oncology.

In a retrospective study. liquid nitrogen preserved specimens from 50 women with primary breast cancer, who underwent surgery at the Beijing Institute for Cancer Research between June. 1986 and September, 1988, were investigated. All patients under this study were staged in TNM II or later, involved with axillary lymph node metastasis. and treated with systemic postoperative adjuvant chemotherapy. The median length of follow-up was 69 months. The expression of P-glycoprotein was investigated by means of immunohistochemistry, using a monoclonal antibody C219 specifically against P-glycoprotein and avidin -biotin peroxidase method. Posrtive staining for P-glycoprotein was found in 23(16%) of the 50 patients. The P-glycoprotein expression negative group fared better than the group that was P-glycoprotein posrtive in overall survival curves (p= 0. 0008 , by the generalized Wilcoxon test). The prognostic effect of P-glycoprotein expression remained statistically significant (p=0. 0007) after adjustment by multivariate analysis(Cox’s model)for other prognostic factors. It is demonstrated that P-glycoprotein expression is a significant and independent Predictor of postoperative survival in breast cancer patients. The results of the present study suggest that P-glycoprotein expression might also influence the bioiogical behavior of breast cancers.

关键词： breast cancer disease outcome P-glycoprotein expression

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