Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States

作     者：Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless 

作者机构：Department of MedicineDivision of Gastroenterology and HepatologyJohns Hopkins University Guangdong provincial Key Laboratory of Colorectal and Pelvic Floor Diseasesthe Sixth Affiliated Hospital of Sun Yat-sen University Department of Gastroenterologythe Sixth Affiliated Hospital of Sun Yat-sen University Department of MedicineMed Star Health Internal Medicine Department of Health and Sport SciencesFederal University of Acre Department of MedicineFaculty of Medicine and Health SciencesAn-Najah National University Ravindra Nath Tagore Medical College St Vincent Hospital Department of EpidemiologyJohns Hopkins University Bloomberg School of Public Health 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2016年第7卷第4期

页      面：556-563页

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：Supported by (in part)Johns Hopkins Institute for Clinical and Translational Research No.UL1TR001079 

主　　题：Crohn’s disease Family history Disease outcome Inflammatory bowel disease Epidemiology genetics Environment Medication Surgery 

摘      要：AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn s disease(CD) residing in China and the United States.METHODS We performed a survey-based cross-sectional study of participants with CD recruited from China and the United States.We compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential confounders.RESULTS We recruited 49 participants from China and 145 from the United States.The prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in China.Ileal involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two countries.CONCLUSION The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United States.Despite the potential difference in etiology,surgery and ileal involvement were similar in the two countries.Examining the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.