Family history and disease outcomes in patients with Crohn's disease:A comparison between China and the United States

作     者：Pei-Qi Wang Jun Hu Elie S Al Kazzi Eboselume Akhuemonkhan Min Zhi Xiang Gao Raquel Holand de Paula Pessoa Sami Ghazaleh Tuhina Cornelius Suhel Abbas Sabunwala Shadi Ghadermarzi Kartikeya Tripathi Mark Lazarev Pin-Jin Hu Susan Hutfless 

作者机构：Department of MedicineDivision of Gastroenterology and HepatologyJohns Hopkins University Guangdong provincial Key Laboratory of Colorectal and Pelvic Floor Diseasesthe Sixth Affiliated Hospital of Sun Yat-sen University Department of Gastroenterologythe Sixth Affiliated Hospital of Sun Yat-sen University Department of MedicineMed Star Health Internal Medicine Department of Health and Sport SciencesFederal University of Acre Department of MedicineFaculty of Medicine and Health SciencesAn-Najah National University Ravindra Nath Tagore Medical College St Vincent Hospital Department of EpidemiologyJohns Hopkins University Bloomberg School of Public Health 

出 版 物：《World Journal of Gastrointestinal Pharmacology and Therapeutics》 (世界胃肠药理与治疗学杂志（英文版）（电子版）)

年 卷 期：2016年第7卷第4期

页      面：556-563页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by (in part)Johns Hopkins Institute for Clinical and Translational Research No.UL1TR001079 

主　　题：Crohn’s disease Family history Disease outcome Inflammatory bowel disease Epidemiology genetics Environment Medication Surgery 

摘      要：AIM To investigate the differences in family history of inflammatory bowel disease(IBD) and clinical outcomes among individuals with Crohn s disease(CD) residing in China and the United *** We performed a survey-based cross-sectional study of participants with CD recruited from China and the United *** compared the prevalence of IBD family history and history of ileal involvement,CD-related surgeries and IBD medications in China and the United States,adjusting for potential *** We recruited 49 participants from China and 145 from the United *** prevalence of family history of IBD was significantly lower in China compared with the United States(China:4.1%,United States:39.3%).The three most commonly affected types of relatives were cousin,sibling,and parent in the United States compared with child and sibling in *** involvement(China:63.3%,United States:63.5%) and surgery for CD(China:51.0%,United States:49.7%) were nearly equivalent in the two *** The lower prevalence of familial clustering of IBD in China may suggest that the etiology of CD is less attributed to genetic background or a family-shared environment compared with the United *** the potential difference in etiology,surgery and ileal involvement were similar in the two *** the changes in family history during the continuing rise in IBD may provide further insight into the etiology of CD.