Analysis of influencing factors and interaction of body weight and disease outcome in patients with prediabetes

作     者：Yan-Yan Li Lin-Ping Tong Xian-Dan Wu Dan Lin Yue Lin Xiao-Yang Lin 

作者机构：Department of General PracticeThe First People’s Hospital of Wenling CityWenling 317500Zhejiang ProvinceChina Department of OncologyYueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 200437China Department of General MedicineThe First People’s Hospital of Wenling CityWenling 317500Zhejiang ProvinceChina 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2023年第14卷第10期

页      面：1551-1561页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：The study was reviewed and approved by The First People’s Hospital of Wenling City(Approval No.KY-2019-1024-01) 

主　　题：Prediabetes Type 2 diabetes mellitus Body weight Disease outcome Influencing factors Interactions Lowcarbohydrate diet 

摘      要：BACKGROUND The trend of prediabetes progressing to type 2 diabetes mellitus(T2DM)is prominent,and effective intervention can lead to a return to *** the factors influencing the outcome of prediabetes is helpful to guide clinical *** weight change in patients with prediabetes has not attracted much *** To explore the interaction between body weight and the factors affecting the progression of prediabetes to *** We performed a retrospective analysis of 236 patients with prediabetes and 50 with normal glucose tolerance(NGT),and collected clinical data and follow-up results of all *** on natural blood glucose outcomes,we classified 66 patients with progression to T2DM into the disease progression(DP)group,and 170 patients without progression to T2DM into the disease outcome(DO)*** analyzed the factors that influenced prediabetes outcome and the influence of body weight on prediabetes blood glucose outcome by unconditional logistic regression.A general linear model(univariate)was used to analyze the interaction between body weight and independent influencing *** There were 98 cases of impaired fasting glucose(IFG),90 cases of impaired glucose tolerance(IGT),and 48 cases of coexistent IFG and *** body weight,waist circumference,body mass index,fasting blood glucose,and 2 h plasma glucose of patients with IFG,IGT,and coexistent IFG and IGT were higher than those in patients with NGT(P0.05).Logistic regression analysis showed that body weight,glycosylated hemoglobin,uric acid,fasting insulin,and homeostatic model assessment for insulin resistance were independent factors affecting progression of prediabetes to T2DM(P0.05).Receiver operating characteristic curve analysis showed that the area under the curve predicted by the above indicators combined was 0.905[95%confidence interval(CI):0.863-0.948],which was greater than that predicted by each indicator *** regression analysis with