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Global trends in publications regarding macrophages-related diabetic foot ulcers in the last two decades

World Journal of Diabetes 2024年第7期15卷 1627-1644页

作者： Jian-Ping Wen Shuan-Ji Ou Jia-Bao Liu Wei Zhang Yu-Dun Qu Jia-Xuan Li Chang-Liang Xia Yang Yang Yong Qi Chang-Peng Xu Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan UniversityGuangzhou 510000Guangdong ProvinceChina The Second School of Clinical Medicine Southern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND diabetic foot ulcers(DFUs)are one of the most severe and popular complications of *** persistent non-healing of DFUs is the leading cause of amputation,which causes significant mental and financial stress to patients and their *** are critical cells in wound healing and perform essential roles in all phases of wound ***,no studies have been carried out to systematically illustrate this area from a scientometric point of *** there have been some bibliometric studies on diabetes,reports focusing on the investigation of macrophages in DFUs are *** To perform a bibliometric analysis to systematically assess the current state of research on macrophage-related *** The publications of macrophage-related DFUs from January 1,2004,to December 31,2023,were retrieved from the Web of Science Core Collection on January 9,*** different analytical tools:VOSviewer(v1.6.19),CiteSpace(v6.2.R4),HistCite(v12.03.07),and Excel 2021 were used for the scientometric *** A total of 330 articles on macrophage-related DFUs were *** most published countries,institutions,journals,and authors in this field were China,Shanghai Jiao Tong University of China,Wound Repair and Regeneration,and Aristidis *** the analysis of keyword co-occurrence networks,historical direct citation networks,thematic maps,and trend topics maps,we synthesized the prevailing research hotspots and emerging trends in this *** Our bibliometric analysis provides a comprehensive overview of macrophage-related DFUs research and insights into promising upcoming research.

关键词： diabetic foot ulcers Macrophage Macrophage polarization Bibliometrics Wound healing Inflammation

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Clinical comprehensive treatment protocol for managing diabetic foot ulcers:A retrospective cohort study

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World Journal of Clinical Cases 2024年第17期12卷 2976-2982页

作者： Yan-Bin Wang Yan Lv Guang-Yu Li Ji-Ting Zheng Qing-Xin Jiang Ran Wei Department of Vascular Surgery Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina First Department of General Surgery Harbin 242 HospitalHarbin 150066Heilongjiang ProvinceChina

BACKGROUND diabetic foot ulcers(DFUs)are a common complication of diabetes,often leading to severe infections,amputations,and reduced quality of *** current standard treatment protocols for DFUs have limitations in promoting efficient wound healing and preventing complications.A comprehensive treatment approach targeting multiple aspects of wound care may offer improved outcomes for patients with *** hypothesis of this study is that a comprehensive treatment protocol for DFUs will result in faster wound healing,reduced amputation rates,and improved overall patient outcomes compared to standard treatment *** To compare the efficacy and safety of a comprehensive treatment protocol for DFUs with those of the standard treatment *** This retrospective study included 62 patients with DFUs,enrolled between January 2022 and January 2024,randomly assigned to the experimental(n=32)or control(n=30)*** experimental group received a comprehensive treatment comprising blood circulation improvement,debridement,vacuum sealing drainage,recombinant human epidermal growth factor and anti-inflammatory dressing,and skin *** control group received standard treatment,which included wound cleaning and dressing,antibiotics administration,and surgical debridement or amputation,if *** taken to reduce the white blood cell count,number of dressing changes,wound healing rate and time,and amputation rate were *** The experimental group exhibited significantly better outcomes than those of the control group in terms of the wound healing rate,wound healing time,and amputation ***,the comprehensive treatment protocol was safe and well tolerated by the *** Comprehensive treatment for DFUs is more effective than standard treatment,promoting granulation tissue growth,shortening hospitalization time,reducing pain and amputation rate,improving wound healing,and enhancing quality of life.

关键词： diabetic foot ulcers Comprehensive treatment protocol Clinical study White blood cell count Wound healing Amputation rate

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Portraying diabetic foot ulcers: Comparative Evaluation of diabetic foot Infections versus diabetic foot ulcers

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Advances in Infectious Diseases 2024年第2期14卷 297-309页

作者： Jamal Wadi Al Ramahi Leen Sharqawi Sarah AL-Najafi Eman Awwad Haya M. Al-Obaidi Abdel Hafez Mohammad Sara Nofal Dina Riyadh Al-Janabi Ibrahim Zuhair Hamza Jamal Al-Masaeid Mohammed Al-Ithawi Dina Rasheed Bellal O. Al-Far Osama Al-Izi Qutaiba Al-Bustanji School of Medicine The University of Jordan Amman Jordan Department of the Internal Medicine The Specialty Hospital Amman Jordan Department of Pharmacy The Specialty Hospital Amman Jordan Department of the Medical Al Khalidi Hospital Amman Jordan Department of Pharmacy Jordan Hospital Amman Jordan Department of Internal Medicine Jordan Hospital Amman Jordan Department of General Surgery Jordan Hospital Amman Jordan

Background: Confusion often arises in caring for diabetic foot infections and ulcers, especially with antimicrobials;we aim to shed light on this entity and alert healthcare workers to its stewardship. Methods: Records were reviewed between February 2016 and September 2023. Data for patients diagnosed with diabetes and foot ulcers, infected or not, were examined following ICD 9 search terms. Records for patients were included if they were prediabetic/diabetic adults with foot ulcers, more than 18 years old, and on antidiabetic treatment. Patients were excluded if they insulin resistant, with normal HgbA1c levels, wheel-chair dependent, bed-bound, non-diabetic patients, diabetic patients who had vascular lower limb surgery earlier to ulcers, diabetic patients who had aortocoronary bypass, deep venous thrombosis within six months, malignancy, and severe clinical depression. A modified IWGDF/IDSA guidelines definitions for DFI and DFU was considered. Statistical analysis was done using R programming. Statistical methods were employed as appropriate, and a significant P-value was considered for P Results: Most characteristics were well balanced between DFI and DFU, on imaging osteomyelitis and tissue swelling were significantly more in DFI. Endovascular radiological procedures showed angiograms to be considerably more in DFI, while angioplasty was more in DFU, in addition to smoking. Bacteremia was uncommon, and swab cultures were mostly polymicrobial in both ulcers;no clear association with blood bacteria was detected with the polymicrobial growth, though few were concordant. Antimicrobials prescribed for both ulcers were not statistically different except for carbapenems, which were more in DFI (P Conclusion: Attention should be paid to best practices while caring for diabetic ulcers. These include swab culture interpretations, the use of antimicrobials, and plan management according to DFI or DFU to utilize either local care or combination with antimicrobials.

关键词： diabetic foot ulcers diabetic Limb Amputation Antimicrobials Stewardship Broad-Spectrum Antimicrobials in diabetic foot ulcers

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The role of artificial intelligence technology in the care of diabetic foot ulcers: the past, the present, and the future

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World Journal of Diabetes 2022年第12期13卷 1131-1139页

作者： Joseph M Pappachan Bill Cassidy Cornelius James Fernandez Vishnu Chandrabalan Moi Hoon Yap Department of Endocrinology&Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science and Engineering Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Department of Endocrinology&Metabolism Pilgrim HospitalBoston PE219QSUnited Kingdom Department of Data Science Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom

foot ulcers are common complications of diabetes mellitus and substantially increase the morbidity and mortality due to this *** care by regular monitoring of the progress of healing with clinical review of the ulcers,dressing changes,appropriate antibiotic therapy for infection and proper offloading of the ulcer are the cornerstones of the management of foot *** the progress of foot ulcers can be a challenge for the clinician and patient due to logistic issues such as regular attendance in the *** clinics are often busy and because of manpower issues,ulcer reviews can be delayed with detrimental effects on the healing as a result of a lack of appropriate and timely changes in *** photographs have been historically useful to assess the progress of diabetic foot ulcers over the past few *** phones with digital cameras have recently revolutionized the capture of foot ulcer *** can send ulcer photographs to diabetes care professionals electronically for remote monitoring,largely avoiding the logistics of patient transport to clinics with a reduction on clinic *** intelligence-based technologies have been developed in recent years to improve this remote monitoring of diabetic foot ulcers with the use of mobile *** is expected to make a huge impact on diabetic foot ulcer care with further research and development of more accurate and scientific technologies in *** clinical update review aims to compile evidence on this hot topic to empower clinicians with the latest developments in the field.

关键词： diabetic foot ulcers Photographic monitoring Artificial intelligence technology Digital photography Mobile app COVID-19 pandemic

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Current scenario of traditional medicines in management of diabetic foot ulcers:A review

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World Journal of Diabetes 2023年第1期14卷 1-16页

作者： Abhijit S Rayate Basavraj S Nagoba Sachin S Mumbre Hardi B Mavani Ajay M Gavkare Advait S Deshpande Department of Surgery Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Microbiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India Department of Community Medicine Ashwini Rural Medical CollegeSolapur 413006India Department of Physiology Maharashtra Institute of Medical Sciences&Research(Medical College)Latur 413531India

diabetic foot infections and diabetic foot ulcers(DFU)cause significant suffering and are often *** have three important pathogenic factors,namely,microangiopathy causing local tissue anoxia,neuropathy making the foot prone to injuries from trivial trauma,and local tissue hyperglycaemia favouring infection and delaying the wound *** have been the leading cause for non-traumatic amputations of part or whole of the *** medicines focus mainly on euglycaemia,antimicrobials,debridement and wound cover with grafts,and off-loading *** in euglycaemic control,foot care and footwear,systemic antimicrobial therapy,and overall health care access and delivery,have resulted in an overall decrease in ***,the process of wound care after adequate debridement remains a major cost burden globally,especially in developing *** process revolves around two basic concerns regarding control/eradication of local infection and promotion of faster healing in a chronic DFU without *** modulation with various dressings and techniques are often a costly *** aspects of the topical therapy with modern/Western medicines are frequently not *** of and compliance to these therapies are important as both the wounds and their treatment are“chronic.”Naturally occurring agents/medications from traditional medicine systems have been used frequently in different cultures and nations,though without adequate clinical base/*** Chinese medicine involves restoring yin-yang balance,regulating the‘chi’,and promoting local blood *** medicines from India have been emphasizing on‘naturally’available products to control wound infection and promote all the aspects of wound *** is one more group of chemicals which are not pharmaceutical agents but can create acidic milieu in the wound to satisfy the above-mentioned basic *** natural and plant derived products(e.g

关键词： diabetic foot infections diabetic foot ulcers Management Traditional medicines Topical agents Wound healing

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Network pharmacology-based approach for exploring the biotargets and mechanisms of vitamin A for the treatment of diabetic foot ulcers

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Frigid Zone Medicine 2023年第3期3卷 186-192页

作者： Xiaowei Wan Qiuhai Qin Ruitang Xie Xin Li Min Su Laboratory of Environmental Pollution and Integrative Omics Guilin Medical UniversityGuilin 541004China Department of Surgery II.The People's Hospital of Gangbei DistrictGuigang 537100China

Background:In some developing countries,people have little knowledge about the causes of diabetic foot ***,public health education for patients on these conditions is a prerequisite for effective pharmacological *** foot ulcers are a complex symptom of diabetes and are hard to cure due to the lack of efficacious medicine and alternative treatment *** A(VA)is known to have potent biological functions,including skin repair and ***,the potential pharmacological effects and molecular mechanisms of VA on foot ulcers are still to be ***:By using bioinformatic/computational analyses,including network pharmacology,gene ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analysis,we aimed to identify and reveal the pharmacological targets,molecular mechanisms,biological functions,and signaling pathways of VA in the treatment of diabetic foot ***:A total of 66 intersection genes were identified as candidate targets of VA,which are related to diabetic foot ***,18 core genes/targets,namely JUN,MAPK1,THRB,MAPK14,MTNR1B,CXCR3,ESR1,AR,HDAC1,IL-10,CNR1,DRD2,EGFR,ADRA2A,CCND1,RXRB,RARA,and RXRA,were further ***,the biological processes,cell components,and molecular functions which may underlie the effects of VA against diabetic foot ulcers were ***:Based on our findings,we concluded that the pharmacological effects of VA on diabetic foot ulcers primarily involve the promotion of cellular regeneration and proliferation and the inhibition of inflammatory *** core genes/targets may potentially serve as promising biomarkers for the diagnosis of diabetic foot ulcers.

关键词： diabetic foot ulcers vitamin A network pharmacology core genes mechanisms

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Lower extremity amputations and long-term outcomes in diabetic foot ulcers:A systematic review

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World Journal of Diabetes 2020年第9期11卷 391-399页

作者： Ayeshmanthe Rathnayake Apoorva Saboo Usman H Malabu Henrik Falhammar Department of Medicine Townsville University HospitalTownsville 4814QueenslandAustralia School of Medicine and Dentistry James Cook UniversityTownsville 4811QueenslandAustralia Department of Endocrinology Metabolism and DiabetesKarolinska University HospitalStockholm 17176Sweden Department of Molecular Medicine and Surgery Karolinska InstitutetStockholm 17176Sweden

BACKGROUNDDiabetes mellitus causes a large majority of non-traumatic major and minoramputations globally. Patients with diabetes are clinically complex with amultifactorial association between diabetic foot ulcers (DFU) and subsequentlower extremity amputations (LEA). Few studies show the long-term outcomeswithin the cohort of DFU-associated *** highlight the long-term outcomes of LEA as a result of ***/MEDLINE and Google Scholar were searched for key terms, “diabetes”,“foot ulcers”, “amputations” and “outcomes”. Outcomes such as mortality, reamputation,re-ulceration and functional impact were recorded. Peer-reviewedstudies with adult patients who had DFU, subsequent amputation and follow upof at least 1 year were included. Non-English language articles or studiesinvolving children were *** total of 22 publications with a total of 2334 patients were selected against theinclusion criteria for review. The weighted mean of re-amputation was 20.14%,29.63% and 45.72% at 1, 3 and 5 years respectively. The weighted mean of mortality at 1, 3 and 5 years were 13.62%, 30.25% and 50.55% respectively withsignificantly higher rates associated with major amputation, re-amputation andischemic *** LEA, level of the LEA and patient comorbidities were significant riskfactors contributing to re-ulceration, re-amputation, mortality and depreciatedfunctional status.

关键词： Lower extremity amputations Long-term outcomes diabetic foot ulcers Quality of life Re-amputation Diabetes

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Prevalence and Risk Factor of diabetic foot ulcers in a Regional Hospital, Eastern Indonesia

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Open Journal of Nursing 2016年第1期6卷 1-10页

作者： Saldy Yusuf Mayumi Okuwa Muhammad Irwan Saipullah Rassa Baharia Laitung Abdul Thalib Sukmawati Kasim Hiromi Sanada Toshio Nakatani Junko Sugama Division of Health Sciences Graduate School of Kanazawa University Kanazawa Japan Wound Care Clinic Griya Afiat Makassar Indonesia Department of Gerontological Nursing/Wound Care Management Faculty of Medicine University of Tokyo Tokyo Japan Wellness Promotion Science Center Institute of Medical Pharmaceutical and Health Sciences Kanazawa University Kanazawa Japan

Indonesia is one of the top ten diabetes mellittus (DM) countries. However as the main complication of DM, there was lack of studies related to diabetic foot ulcer (DFU). Thus, the aim of this study was to survey the prevalence of DFU risk factors and DFU among type 2 diabetes mellitus (T2DM) patients. An epidemiological study was conducted at an outpatient endocrine clinic in a regional hospital, eastern Indonesia. All T2DM participants attending research setting that were ≥ 18 years were included. Demographic and foot care behavior were assessed using minimum data sheet (MDS). Meanwhile, presence of risk factors was evaluated by using 5.07/10 g Semmes-Weinsten Monofilament (SWM) for neuropathy and presence of angiopathy was evaluated with Ankle Brachial Index (ABI) by using a hand held Doppler (Bidop ES-100V3, Hadeco-Kawasaki, Japan) both dorsal and posterior tibialis foot. At the end of study, 249 T2DM participants were enrolled. The prevalence of DFU risk factors was 55.4% (95% CI: 53.7% - 57.0%), and prevalence of DFU was 12% (95% CI: 10.3% - 13.6%). Based on a logistic regression, predictors for DFU risk factors included age (OR: 1.04;95% CI: 1.005 - 1.074) and daily foot inspection (OR: 0.36;95% CI: 0.186 - 0.703). Meanwhile, the predictors for presence of DFU were insulin (OR: 9.37;95% CI: 2.240 - 39.182), shoes (OR: 0.05;95% CI: 0.007 - 0.294), spiritual belief that DM was a disease (OR: 0.04;95% CI: 0.004 - 0.326) and belief that DM was a temptation from God (OR: 0.13;95% CI: 0.027 - 0.598). In conclusion, we recommend to educate high risk patients to understand positive foot care behavior as essentially preventive strategies to prevent presence risk and DFU.

关键词： Prevalence Diabetes Complications Risk Factors diabetic foot ulcers

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Study of Biofilm Formation and Antibiotic Resistance Pattern of Bacteria Isolated from diabetic foot ulcers in Hôpital de Référence Saint Joseph, Kinshasa, Democratic Republic of Congo

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Advances in Microbiology 2021年第5期11卷 283-295页

作者： Jean-Marie Liesse Iyamba Victoire Marie Hermine Ngo Bassom Cyprien Mbundu Lukukula Joseph Welo Unya Benjamin Kodondi Ngbandani Grégoire Mbusa Vihembo Nelson Nsiata Ngoma José Mulwahali Wambale Paul Tshilumbu Kantola N. B. Takaisi-Kikuni Laboratory of Experimental and Pharmaceutical Microbiology Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Centre Universitaire de Référence de Surveillance de la Résistance aux Antimicrobiens Faculty of Pharmaceutical Sciences University of Kinshasa Kinshasa Democratic Republic of Congo Service de Microbiologie H&ocirc pital de Référence Saint Joseph Limete-Kinshasa Democratic Republic of Congo

foot infections resulting from biofilm producers and multi-drug resistant organisms is one of the most important complications of diabetes mellitus, as it can impede the wound healing process. This study was carried out in order to determine the antibiotic resistance pattern and the biofilm production in diabetic foot ulcers isolates. Clinical samples were collected from patients suffering from diabetic foot ulcers by using sterile swabs. Antibiotic susceptibility test was done using disk diffusion method on Mueller Hinton Agar. Biofilm formation was assessed by Crystal Violet Staining Method. Staphylococcus aureus isolates were resistant to ofloxacin (83.3%), ciprofloxacin (75.0%), trimethoprim-sulphamethoxazole (75.0%), and gentamicin (58.8%) but very sensitive to oxacillin (100.0%) and vancomycin (91.7%). Pseudomonas aeruginosa isolates showed resistance to the commonly used antibiotics such as ofloxacin, cefotaxime, ampicillin (81.8%), ceftazidime and imipenem (72.7%). The majority of bacteria studied were biofilm producers. This study showed that bacteria isolated from diabetic foot ulcers were biofilm producers and presented resistance to commonly used antibiotics. Knowledge on antibiotic sensitivity pattern and biofilm phenotype of the isolates will be helpful in determining the drugs for the treatment of diabetic ulcers.

关键词： Biofilm Formation Antibiotic Resistance diabetic foot ulcers Democratic Republic of Congo

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Adipose-derived stem cells in diabetic foot care:Bridging clinical trials and practical application

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World Journal of Diabetes 2024年第6期15卷 1162-1177页

作者： Song-Lu Tseng Lin Kang Zhu-Jun Li Li-Quan Wang Zi-Ming Li Tian-Hao Li Jie-Yu Xiang Jiu-Zuo Huang Nan-Ze Yu Xiao Long Department of Plastic and Reconstructive Surgery Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Department of Plastic and Reconstructive Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100730China Biomedical Engineering Facility Institute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences BeijingBeijing 100021China

diabetic foot ulcers(DFUs)pose a critical medical challenge,significantly impairing the quality of life of ***-derived stem cells(ADSCs)have been identified as a promising therapeutic approach for improving wound healing in *** extensive exploration of the mechanical aspects of ADSC therapy against DFU,its clinical applications remain *** this review,we aimed to bridge this gap by evaluating the use and advancements of ADSCs in the clinical management of *** review begins with a discussion of the classification and clinical management of diabetic foot *** then discusses the current landscape of clinical trials,focusing on their geographic distribution,reported efficacy,safety profiles,treatment timing,administration techniques,and dosing ***,the review discusses the preclinical strategies to enhance ADSC *** review shows that many trials exhibit biases in study design,unclear inclusion criteria,and intervention *** conclusion,this review underscores the potential of ADSCs in DFU treatment and emphasizes the critical need for further research and refinement of therapeutic approaches,with a focus on improving the quality of future clinical trials to enhance treatment outcomes and advance the field of diabetic wound care.

关键词： Adipose-derived stem cells diabetic foot ulcers Wound healing Clinical

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