Lower extremity amputations and long-term outcomes in diabetic foot ulcers:A systematic review

作     者：Ayeshmanthe Rathnayake Apoorva Saboo Usman H Malabu Henrik Falhammar 

作者机构：Department of MedicineTownsville University HospitalTownsville 4814QueenslandAustralia School of Medicine and DentistryJames Cook UniversityTownsville 4811QueenslandAustralia Department of EndocrinologyMetabolism and DiabetesKarolinska University HospitalStockholm 17176Sweden Department of Molecular Medicine and SurgeryKarolinska InstitutetStockholm 17176Sweden 

出 版 物：《World Journal of Diabetes》 (世界糖尿病杂志（英文版）（电子版）)

年 卷 期：2020年第11卷第9期

页      面：391-399页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Lower extremity amputations Long-term outcomes Diabetic foot ulcers Quality of life Re-amputation Diabetes 

摘      要：BACKGROUNDDiabetes mellitus causes a large majority of non-traumatic major and minoramputations globally. Patients with diabetes are clinically complex with amultifactorial association between diabetic foot ulcers (DFU) and subsequentlower extremity amputations (LEA). Few studies show the long-term outcomeswithin the cohort of DFU-associated *** highlight the long-term outcomes of LEA as a result of ***/MEDLINE and Google Scholar were searched for key terms, “diabetes,“foot ulcers, “amputations and “outcomes. Outcomes such as mortality, reamputation,re-ulceration and functional impact were recorded. Peer-reviewedstudies with adult patients who had DFU, subsequent amputation and follow upof at least 1 year were included. Non-English language articles or studiesinvolving children were *** total of 22 publications with a total of 2334 patients were selected against theinclusion criteria for review. The weighted mean of re-amputation was 20.14%,29.63% and 45.72% at 1, 3 and 5 years respectively. The weighted mean of mortality at 1, 3 and 5 years were 13.62%, 30.25% and 50.55% respectively withsignificantly higher rates associated with major amputation, re-amputation andischemic *** LEA, level of the LEA and patient comorbidities were significant riskfactors contributing to re-ulceration, re-amputation, mortality and depreciatedfunctional status.