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Yinlai decoction Protects Microstructure of Colon and Regulates Serum Level of d-lactic acid in Pneumonia Mice Fed with High-Calorie and High-Protein diet

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Chinese Journal of Integrative Medicine 2023年第8期29卷 714-720页

作者： WANG Yun-hui YU He LIU Tie-gang Teck Chuan Kong ZHENG Zi-an WAN Yu-xiang BAI Chen HAO Yu MAO Ying-qiu WU Jun XU Jing-nan CUI Li-jun WANG Yu-han SHAN Yan-ran SHAO Ying-jun GU Xiao-hong College of Chinese Medicine Beijing University of Chinese MedicineBeijing(100029)China Nanyang Technological University Singapore

Objective To investigate the effect of Yinlai decoction(Yd)on the microstructure of colon,and activity of d-lactic acid(dLA)and diamine oxidase(dAO)in serum of pneumonia mice model fed with high-calorie and high-protein diet(HCd).Methods Sixty male Kunming mice were randomly divided into 6 groups by the random number table method:normal control,pneumonia,HCd,HCd with pneumonia(HCd-P),Yd(229.2 mg/mL),and dexamethasone(15.63 mg/mL)groups,with 10 in each group.HCd mice were fed with 52%milk solution by gavage.Pneumonia mice was modeled with lipopolysaccharide inhalation and was fed by gavage with either the corresponding therapeutic drugs or saline water,twice daily,for 3 days.After hematoxylin-eosin staining,the changes in the colon structure were observed under light microscopy and transmission electron microscope,respectively.Enzyme-linked immunosorbent assay was used to detect the protein levels of dLA and dAO in the serum of mice.Results The colonic mucosal structure and ultrastructure of mice in the normal control group were clear and intact.The colonic mucosal goblet cells in the pneumonia group tended to increase,and the size of the microvilli varied.In the HCd-P group,the mucosal goblet cells showed a marked increase in size with increased secretory activity.Loose mucosal epithelial connections were also observed,as shown by widened intercellular gaps with short sparse microvilli.These pathological changes of intestinal mucosa were significantly reduced in mouse models with Yd treatment,while there was no significant improvement after dexamethasone treatment.The serum dLA level was significantly higher in the pneumonia,HCd,and HCd-P groups as compared with the normal control group(PdLA was significantly lower in the Yd group than HCd-P group(PdLA level significantly increased in the dexamethasone group as compared with the Yd group(PdAO among groups(P>0.05).Conclusions Yd can protect function of intestinal

关键词： Yinlai decoction Chinese medicine pneumonia microstructure d-lactic acid diamine oxidase

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Value of combining the serum d-lactate, diamine oxidase, and endotoxin levels to predict gut-derived infections in cancer patients

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Journal of Nutritional Oncology 2023年第2期8卷 101-106页

作者： Shou-Mei Yang Xiao-dan Zhang Huai-XingMa danWu XingLiu Hao-Bin Yu Shi-Wei Li Wen-Jun Gao Wei-Wei Liu Su-Yi Li department of Nutrition and Metabolism of Oncology Anhui Provincial Cancer HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001AnhuiChina department of Pharmacy Anhui Provincial Cancer HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001AnhuiChina

Objective:This is a retrospective observational cohort study.The objective of this retrospective observational cohort study was to evaluate the value of the combined serum d-lactic acid,diamine oxidase(dAO),and endotoxin levels to predict intestinal barrier impairment and gut-derived infection(GdI)in cancer patients.Methods:Cancer patients receiving chemotherapy or palliative care treatment at our hospital were enrolled in the study.The serum concentrations of dAO,d-lactic acid,and endotoxin were determined using the intestinal barrier function biochemical index analysis system.The patients'infection information came from the hospital's Medicom Prescription Automatic Screening System and themedical records.Three hundred fifty-three cancer patients were included in the study(53.8%female,73.7%cancer stage IV,27.8%had bowel obstruction).Results:The total incidence of GdI was 33.4%(118/353).The median length of hospital stay was 16 days for patients with GdI,compared with 7 days for patients without GdI(Pdia hospitalization costs were¥27,362.35 for patients with GdI compared with¥11,614.08 for patients without GdI(PdAO,d-lactic acid,and endotoxin were significantly higher in patients with GdI.As malignant bowel obstruction(MBO)worsened,the concentrations of dAO,d-lactic acid,and endotoxin increased.Multivariate logistic regression models revealed that the dAO,endotoxin,IL-6,and C-reactive protein levels were significantly associated with an increased risk of GdI.In addition,we also found a fivefold increased risk of infection in patients withMBO compared with those without bowel obstruction(OR=6.210,Pder the receiver operating characteristic curve(AUCs)for dAO,d-lactate,and endotoxin to predict GdI wered(dAO+d-lactate+endotoxin),the predictive power increased significantly(AUC=0.797,P<0.001).Moreover,combining these intestinal barri

关键词： Cancer diamine oxidase d-lactic acid Endotoxin Gut-derived infection

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