Value of combining the serum D-lactate, diamine oxidase, and endotoxin levels to predict gut-derived infections in cancer patients

作     者：Shou-Mei Yang Xiao-Dan Zhang Huai-XingMa DanWu XingLiu Hao-Bin Yu Shi-Wei Li Wen-Jun Gao Wei-Wei Liu Su-Yi Li Shou-Mei Yang;Xiao-Dan Zhang;Huai-Xing Ma;Dan Wu;Xing Liu;Hao-Bin Yu;Shi-Wei Li;Wen-Jun Gao;Wei-Wei Liu;Su-Yi Li

作者机构：Department of Nutrition and Metabolism of OncologyAnhui Provincial Cancer HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001AnhuiChina Department of PharmacyAnhui Provincial Cancer HospitalThe First Affiliated Hospital of University of Science and Technology of ChinaHefei 230001AnhuiChina 

出 版 物：《Journal of Nutritional Oncology》 (肿瘤营养学杂志（英文）)

年 卷 期：2023年第8卷第2期

页      面：101-106页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：Cancer Diamine oxidase D-Lactic acid Endotoxin Gut-derived infection 

摘      要：Objective:This is a retrospective observational cohort *** objective of this retrospective observational cohort study was to evaluate the value of the combined serum D-lactic acid,diamine oxidase(DAO),and endotoxin levels to predict intestinal barrier impairment and gut-derived infection(GDI)in cancer ***:Cancer patients receiving chemotherapy or palliative care treatment at our hospital were enrolled in the *** serum concentrations of DAO,D-lactic acid,and endotoxin were determined using the intestinal barrier function biochemical index analysis *** patients infection information came from the hospital s Medicom Prescription Automatic Screening System and themedical *** hundred fifty-three cancer patients were included in the study(53.8%female,73.7%cancer stage IV,27.8%had bowel obstruction).Results:The total incidence of GDI was 33.4%(118/353).The median length of hospital stay was 16 days for patients with GDI,compared with 7 days for patients without GDI(P0.001).The media hospitalization costs were¥27,362.35 for patients with GDI compared with¥11,614.08 for patients without GDI(P0.001).The serum concentrations of DAO,D-lactic acid,and endotoxin were significantly higher in patients with *** malignant bowel obstruction(MBO)worsened,the concentrations of DAO,D-lactic acid,and endotoxin *** logistic regression models revealed that the DAO,endotoxin,IL-6,and C-reactive protein levels were significantly associated with an increased risk of *** addition,we also found a fivefold increased risk of infection in patients withMBO compared with those without bowel obstruction(OR=6.210,P0.001).All of the areas under the receiver operating characteristic curve(AUCs)for DAO,D-lactate,and endotoxin to predict GDI were0.7(AUC=0.648,P0.001;AUC=0.624,P0.01;AUC=0.620,P0.01,respectively).However,when the parameters were combined(DAO+D-lactate+endotoxin),the predictive power increased significantly(AUC=0.797,P