Yinlai Decoction Protects Microstructure of Colon and Regulates Serum Level of D-Lactic Acid in Pneumonia Mice Fed with High-Calorie and High-Protein Diet

作     者：WANG Yun-hui YU He LIU Tie-gang Teck Chuan Kong ZHENG Zi-an WAN Yu-xiang BAI Chen HAO Yu MAO Ying-qiu WU Jun XU Jing-nan CUI Li-jun WANG Yu-han SHAN Yan-ran SHAO Ying-jun GU Xiao-hong 

作者机构：College of Chinese MedicineBeijing University of Chinese MedicineBeijing(100029)China Nanyang Technological UniversitySingapore 

出 版 物：《Chinese Journal of Integrative Medicine》 (中国结合医学杂志（英文版）)

年 卷 期：2023年第29卷第8期

页      面：714-720页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1005[医学-中医学] 1002[医学-临床医学] 100602[医学-中西医结合临床] 10[医学] 

基　　金：Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTD-C-202006) 

主　　题：Yinlai Decoction Chinese medicine pneumonia microstructure D-lactic acid diamine oxidase 

摘      要：Objective To investigate the effect of Yinlai Decoction(YD)on the microstructure of colon,and activity of D-lactic acid(DLA)and diamine oxidase(DAO)in serum of pneumonia mice model fed with high-calorie and high-protein diet(HCD).Methods Sixty male Kunming mice were randomly divided into 6 groups by the random number table method:normal control,pneumonia,HCD,HCD with pneumonia(HCD-P),YD(229.2 mg/mL),and dexamethasone(15.63 mg/mL)groups,with 10 in each *** mice were fed with 52%milk solution by *** mice was modeled with lipopolysaccharide inhalation and was fed by gavage with either the corresponding therapeutic drugs or saline water,twice daily,for 3 *** hematoxylin-eosin staining,the changes in the colon structure were observed under light microscopy and transmission electron microscope,***-linked immunosorbent assay was used to detect the protein levels of DLA and DAO in the serum of *** The colonic mucosal structure and ultrastructure of mice in the normal control group were clear and *** colonic mucosal goblet cells in the pneumonia group tended to increase,and the size of the microvilli *** the HCD-P group,the mucosal goblet cells showed a marked increase in size with increased secretory *** mucosal epithelial connections were also observed,as shown by widened intercellular gaps with short sparse *** pathological changes of intestinal mucosa were significantly reduced in mouse models with YD treatment,while there was no significant improvement after dexamethasone *** serum DLA level was significantly higher in the pneumonia,HCD,and HCD-P groups as compared with the normal control group(P0.05).Co