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Food Science and Human Wellness 2024年第1期13卷 115-123页

作者： Yue Yu Haibin Zhu Mingyue Shen Qiang Yu Yi Chen Shiru Mo Jianhua Xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China International Institute of Food Innovation Nanchang UniversityNanchang 330200China

The biological activity of plant polysaccharides can be enhanced by sulfated *** this study,the immunomodulatory effect of sulfated cyclocarya paliurus polysaccharides(SCP3)on macrophages RAW264.7 and its potential molecular mechanism were *** showed that SCP3 at 25-100μg/m L increased viability and improved phagocytosis of RAW264.7 ***,SCP3 could activate mitogen-activated protein kinase(MAPK)and nuclear factor kappa B(NF-κB)signaling pathways,which increased the phosphorylation of Erk1/2,JNK,p38 and NF-κB p65,promoting secretion of cytokines tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and nitric oxide(NO)as well as the production of reactive oxygen species(ROS).In addition,Toll-like receptor 4(TLR4)receptor inhibitors were able to block the production of NO and TNF-αby SCP3-stimulated *** on Western blot analysis and validation using specific inhibitors against MAPK and NF-κB signaling pathways,the results demonstrated that SCP3 induced macrophages activation and enhanced TNF-αand NO production via TLR4-mediated MAPK and NF-κB *** summary,SCP3 has significant immunomodulatory *** underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production,which in turn activates the downstream MAPK/NF-κB signaling pathway and then increases the secretion levels of cytokines and NO.

关键词： cyclocarya paliurus Sulfated polysaccharides Macrophages Immunomodulatory Mechanism

Cyclocarysaponins A–J, dammarane-type triterpenoid glycosides from the leaves of cyclocarya paliurus

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Chinese Journal of Natural Medicines 2024年第10期22卷 955-964页

作者： XI Huiting YUAN Mingming XIE Jianhua WANG Yuanxing State Key Laboratory of Food Science and Resources Nanchang University Jiangxi Institute for Drug Control NMPA Key Laboratory of Quality Evaluation of Traditional Chinese Patent Medicine Jiangxi Provincial Engineering Research Center of Drug and Medical Device Quality

Ten previously undescribed dammarane-type triterpenoid glycosides, cyclocarysaponins A–J(1–10), were isolated from the leaves of cyclocarya paliurus(Batal.) Iljinskaja. The structures of these compounds were characterized through detailed spectroscopic analysis, including 1D and 2D nuclear magnetic resonance(NMR) and high-resolution electrospray ionization mass spectrometry(HR-ESI-MS). The cytotoxic activities of all isolates were assessed against five human cancer cell lines(Bel-7402, Caski, BGC-823, A2780, and HCT-116). Of the tested compounds, compounds 1, 7, and 9 exhibited selective cytotoxicity against one or more human cancer cell lines.

关键词： cyclocarya paliurus Cyclocarysaponin Cytotoxic activities Juglandaceae Triterpenoid glycosides

Natural variations in flavonoids and triterpenoids of cyclocarya paliurus leaves

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Journal of Forestry Research 2021年第2期32卷 805-814页

作者： Caowen Sun Xulan Shang Haifen Ding Yanni Cao Shengzuo Fang College of Forestry Nanjing Forestry UniversityNanjing 210037People’s Republic of China Co-Innovation Center for Sustainable Forestry in Southern China Nanjing Forestry UniversityNanjing 210037People’s Republic of China

cyclocarya paliurus is widely distributed in subtropical areas of *** metabolites in the leaves,including flavonoids and triterpenoids,provide protection against diseases such as hyperlipidemia,diabetes,hypertension,and *** this study,343 *** leaves were collected from 32 distinct populations covering most of the main distribution,to deduce the response of flavonoids and triterpenoids to seven environmental *** component analysis was performed using seven flavonoid and six triterpenoid *** results show that altitude,latitude,and longitude significantly contributed to variations in total flavonoid and triterpenoid *** addition,the interaction of these metabolites was extensively correlated with environment changes,and therefore should be considered during selection and cultivation.

关键词： cyclocarya paliurus Environmental factors Flavonoids Secondary metabolite variation Triterpenoids

Antioxidative and immunological effects of cyclocarya paliurus polysaccharides on the spleen injury of diabetic rats

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Journal of Traditional Chinese Medicine 2021年第5期41卷 739-746页

作者： XIA Xichao LI Bin QIU Ju TIAN Gang CHEN Changdong LA Ming ZHANG Ke QI Jinxu LI Yanyan GAO Huashan SHAO Xiangyang SU Congying WANG Mengqi OUYANG Jingfeng Medical College Pingdingshan UniversityPingdingshan 467000China College of Chemistry and Chemical Engineering Pingdingshan UniversityPingdingshan 467000China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJEVTIVE:To investigate the effects of cyclocarya paliurus(***)polysaccharides on the spleen injury of diabetic ***:Animals were divided into 6 groups,including normal group,model group,control group,low-dose group of *** polysaccharides treatment,middle-dose group of *** polysaccharides treatment and high-dose group of *** polysaccharides *** analysis of spleen was analyzed using hematoxilin and *** of biological parameters and anti-oxidative enzymes were determined by ***-7(IL-7)and IL-10 were measured by enzyme-linked immunosorbent ***:Compared with that of model group,superoxide dismutase,catalase,glutathione peroxidase,glutathione reductase level increased 78.63%(P<0.05),51.76%(P<0.05),2.95 times(P<0.01)and 41.11%(P<0.05)in the high-dose group of *** polysaccharides treatment,***-7 and IL-10 increase 1.66(P<0.01)and 1.21 times(P<0.01)in the high-dose group of *** polysaccharides treatment,***:It is suggested that *** polysaccharides may play a protecting role for spleen injury of diabetic rats by enhancing the antioxidative ability and evaluating the immunity.

关键词： spleen diabetes mellitus antioxidants polysaccharides cyclocarya paliurus

Effect of cyclocarya paliurus polysaccharides on streptozotocin-induced diabetic nephropathy in rats

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Journal of Traditional Chinese Medicine 2020年第6期40卷 956-964页

作者： Xia Xichao Mao Dongxue Dai Hongmei Wu Xi Zhang Zuyuan Wang Huaying Zhou Wenwen Dong Yanmei Wang Mengqi Li Yuan Shao Xiangyang Ouyang Jingfeng Medical College Pingdingshan UniversityPingdingshan 467000China Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research CenterChina Academy of Chinese Medical SciencesBeijing 100700China

OBJEVTIVE:To investigate the efficacy of cyclocarya paliurus(***)polysaccharides on streptozotocin-induced diabetic nephropathy in ***:Rats were divided into 6 groups,including group of normal control,group of diabetic control,group of metformin treatment,low-dose group of *** polysaccharides treatment,middle-dose group of *** polysaccharides treatment and high-dose group of *** polysaccharides *** analysis of kidney was analyzed using hematoxilin and *** of blood glucose,creatinine,urea,uric acid were determined by ***-oxidative enzymes were measured by real-time polymerase chain reaction(PCR)and enzyme-linked immunosorbent assay(ELISA).Advanced glycation end products(AGEs)and transforming growth factor-β1(TGF-β1)level was measured by ***:Abnormal changes were observed in the group of diabetic control characterized by atrophy of the renal glomeruli with hypercellularity,congestion of glomerular tufts,dilation of the renal spaces,and degeneration of renal *** with that of normal group,blood glucose,creatinine,urea,uric acid level was significantly increased in the group of diabetic *** dismutase,catalase,glutathione peroxidase,glutathione reductase level was significantly decreased,but AGEs and TGF-β1 level was significantly *** contrast,administration of *** polysaccharides and metformin could reverse the above-mentioned results of the group of diabetic control,especially in the high-dose group of *** ***:Our findings suggest that *** polysaccharides may play a protecting role for nephropathy of diabetic rats by lowering glucose,creatinine,urea,uric acid level,enhancing the antioxidative ability,and reducing AGEs and TGF-β1 expression.

关键词： Diabetic nephropathies cyclocarya paliurus Polysaccharides Antioxidatnts Glycation end products advanced Transforming growth factor beta1

Whole-genome Duplication Reshaped Adaptive Evolution in A Relict Plant Species,cyclocarya paliurus

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Genomics, Proteomics & Bioinformatics 2023年第3期21卷 455-469页

作者： Yinquan Qu Xulan Shang Ziyan Zeng Yanhao Yu Guoliang Bian Wenling Wang Li Liu Li Tian Shengcheng Zhang Qian Wang Dejin Xie Xuequn Chen Zhenyang Liao Yibin Wang Jian Qin Wanxia Yang Caowen Sun Xiangxiang Fu Xingtan Zhang Shengzuo Fang Nanjing Forestry University Co-Innovation Center for Sustainable Forestry in Southern ChinaNanjing 210037China Shenzhen Branch Guangdong Laboratory for Lingnan Modern AgricultureGenome Analysis Laboratory of the Ministry of AgricultureAgricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120China Center for Genomics and Biotechnology Fujian Provincial Key Laboratory of Haixia Applied Plant Systems BiologyKey Laboratory of GeneticsBreeding and Multiple Utilization of CropsMinistry of EducationFujian Agriculture and Forestry UniversityFuzhou 350002China

cyclocarya paliurus is a relict plant species that survived the last glacial period and shows a population expansion *** leaves have been traditionally used to treat obesity and diabetes with the well-known active ingredient cyclocaric acid ***,we presented three *** genomes from two diploids with different flower morphs and one haplotype-resolved tetraploid *** genomic analysis revealed two rounds of recent whole-genome duplication events and identified 691 genes with dosage effects that likely contribute to adaptive evolution through enhanced photosynthesis and increased accumulation of *** analysis of 45 *** individuals uncovered two bottlenecks,consistent with the known events of environmental changes,and many selectively swept genes involved in critical biological functions,including plant defense and secondary metabolite *** also proposed the biosynthesis pathway of cyclocaric acid B based on multi-omics data and identified key genes,in particular gibberellinrelated genes,associated with the heterodichogamy in *** *** study sheds light on evolutionary history of *** and provides genomic resources to study the medicinal herbs.

关键词： cyclocarya paliurus Genomics Whole-genome duplication Triterpenoid Resequencing

First detection of Diaporthe eucommiae causing leaf black blight disease on cyclocarya paliurus

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First detection of Diaporthe eucommiae causing leaf black bl...

Study on Response Surface Methodology Optimization for Extraction Process of cyclocarya paliurus Extract and Its Blood Sugar-lowering Effect

中国植物病理学会第十一届全国会员代表大会暨2018年学术年会

作者： Jiang Dan He Huanhuan Peng Xixu Tao Zong Xiao Ting Wang Haihua School of Life Science Hunan University of Science and Technology Key Laboratory of Ecological Remediation and Safe Utilization of Heavy Metal-polluted Soils College of Hunan Province

During the vegetation period(March to October) of 2013 and 2014,an outbreak of leaf black blight was observed on cyclocarya paliurus plants in three plantations in Chengbu County,Hunan Province,China.A Diaporthe species was consistently isolated from the diseased leaflets or *** on the morphological characteristics of colony appearance,shape of conidia and conidiomata as well as sequences of internal transcribed spacer regions(ITS),the fungus was identified as Diaporthe *** test showed that *** isolates caused the symptoms originally observed on those of naturally infected plants,and the pathogenic isolates were successfully re-isolated from inoculated leaflets,thus fulfilling Koch’s *** is the first report of *** causing leaf black blight on *** screening indicated that the *** isolates were highly sensitive to thiophanate-methyl,chlorothalonil and iprodione,suggesting that practical use of these three fungicides has high potentials to control the leaf black blight on ***.

关键词： Diaporthe eucommiae Leaf black blight Identification of pathogen cyclocarya paliurus

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Agricultural Biotechnology 2020年第5期9卷 127-133页

作者： Yufeng LI Xiayun LIAO Gang WANG Lichun ZHAO College of Pharmacy Guangxi University of Chinese MedicineNanning 530200China Guangxi Zhuang Yao Medicine Center of Engineering and Technology Nanning 530200China

[Objectives]This study was conducted to discuss the mechanism of the blood sugar-lowering effect of cyclocarya paliurus extract.[Methods]With *** leaves as the raw material,the ethyl acetate-butyl acetate microwave extraction process of *** was *** the yield of *** extract as an evaluation index,single-factor experiments were carried out on such 6 factors as the dry *** leaf powder size,solid-to-liquid ratio,extraction time,microwave frequency,microwave power,and microwave extraction time,and the extraction and purification process was further optimized by response surface *** normal mice and the hyperglycemic mice modeled by alloxan were injected with *** extract to study the blood sugar-lowering effects of different groups of *** extract.[Results]The optimal process combination for the extraction of *** leaves was obtained:dry *** powder size 90-100 mesh,solid-to-liquid ratio 1∶20(g/ml),extraction time 192 min,microwave frequency 2500 MHz,microwave power 490 W,and extraction time 248 *** these conditions,the yield of *** extract reached the maximum,95.10%,reaching 99.83%of the predicted *** blood sugar-lowering test on mice showed that the *** extract had a good effect on lowering blood sugar,indicating that *** extract can improve the free radical scavenging capacity to a certain extent.[Conclusions]This study provides certain reference for the in-depth study of the physiological effects of *** extract and the comprehensive development and utilization of *** extract.

关键词： cyclocarya paliurus C.paliurus extract Yield Blood sugar lowering Radical scavenging