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Elevated serum levels of ghrelin and TNF-a in patients with cyanotic and acyanotic congenital heart disease

World Journal of Pediatrics 2017年第2期13卷 122-128页

作者： Sai Zhang Gong-Liang Guo Li-Li Yang Li-Qun Sun Outpatient Department of Pediatrics No.1 Hospiml of Jilin UniversityChangchunChina Department of Cardiology the Third Hospital ofJilin UniversityChangchunChina Department of Gynecology and Obstetrics No.1 Hospital of Jilin UniversityChangchunChina

Background:The levels of ghrelin and tumor necrosis factor alpha (TNF-a) are considered biological markers of congenital heart diseases (CHD).The present meta-analysis was conducted to investigate the clinical significance of serum levels of ghrelin and TNF-α in children with (CHD).Methods:Chinese and English scientific literature databases were searched to retrieve published studies relevant to ghrelin,TNF-α and *** search was additionally employed to identify other relevant studies from *** retrieved studies were screened on the basis of our stringent inclusion and exclusion criteria to select high quality case-control studies for ***:We initially retrieved 108 published studies (20 in Chinese and 88 in English) from database ***,6 case-control studies (5 in English and 1 in Chinese) were enrolled in our meta-analysis,and contained a total of 160 cyanotic congenital heart disease (CCHD) patients and 215 acyanotic congenital heart disease (ACHD) patients,along with 162 healthy *** results of meta-analysis showed that serum levels of ghrelin and TNF-α in CCHD or ACHD children were significantly higher than those in healthy ***:Our meta-analysis results showed that serum levels of ghrelin and TNF-α are elevated in children with CHD,and could be used as effective biologic markers in early diagnosis of CHD.

关键词： acyanotic congenital heart disease cyanotic ghrelin meta-analysis TNF-α

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Metabolic profile of heart tissue in cyanotic conaenital heart disease

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中国循环杂志 2018年第S1期33卷 123-123页

作者： Kai Chen Jiangping Song State Key Laboratory of Cardiovascular Disease National Center for Cardiovascular DiseasesFuwai HospitalCAMS and PUMCBeijingChina

Background cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological *** in the protective mechanisms of cardiomyocytes to chronic hypoxia have the potential to provide novel treatment strategies for many *** is a study of metabolism at global level,which capture global biochemical events by assaying thousands of small molecules in tissues,followed by application of bioinformatics to define metabolomic signatures of the *** order to describe the features of metabolic remodeling of the heart of CCHD,we conducted our study on the effect of hypoxia on metabolism of human heart by using tissue from patients with CCHD compared with that from patients with non-cyanotic CHD(NCCHD).

关键词： cyanotic congenital heart disease(CCHD) birth anomaly non-cyanotic CHD(NCCHD)

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Transcriptional Profile Alteration of Peripheral Blood in Chronic Hypoxia

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Chinese Medical Sciences Journal 2020年第1期35卷 54-64页

作者： Tingting Wang Junyue Xing Lijing Zhang Hao Zhang State Key Laboratory of Cardiovascular Diseases Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100037China Heart Center and Shanghai Institution of Pediatric Congenital Heart Diseases Shanghai Children's Medical CenterNational Children's Medical CenterShanghai Jiao Tong University School of MedicineShanghai 200127China Children's Heart Center The Second Affiliated Hospital and Yuying Children's HospitalInstitute of Cardiovascular Development and Translational MedicineWenzhou Medical UniversityWenzhouZhejiang 325027China

Objective Many physiological and pathological conditions,including cyanotic congenital heart diseases(CCHD),are accompanied by chronic hypoxia,which might interfere with the transcription ***,the transcriptome profile in peripheral blood under hypoxia is still *** present work aimed to explore the transcriptional profile alteration of peripheral blood in chronic *** The present study used a chronic hypoxia rat model to simulate the hypoxic state of CCHD *** groups of Sprague-Dawley rats(n=6 per group)were either exposed to hypoxia(10%O2)or normoxia(21%O2)for 3 *** weight was measured *** blood was collected and total RNA was extracted for RNA-Seq at the end of the hypoxia *** quality assessment,the library was sequenced by the Illumina Hiseq *** differentially expressed genes were screened(false discovery rate2).The functional annotation analysis and cluster analysis of differentially expressed genes were performed based on the adjusted P-value(padj<0.05).Results Compared with the control group,the body weight of the rats in the hypoxia group was significantly lowered(P<0.01).RNA-Seq results showed that the transcriptome patterns of the two groups had significant *** total,872 genes were identified as differentially *** all,803 genes were downregulated,while only 69 genes were up-regulated in the hypoxia *** functional enrichment analysis of the 872 genes showed that multiple biological processes involved,such as porphyrin-containing compound metabolic process,hemoglobin complex and oxygen transporter *** Our study demonstrated the transcriptional profile alteration in peripheral blood of chronic hypoxia rat *** study provided basic data and directions to further understand the physiological and pathological changes in patients with CCHD.

关键词： chronic hypoxia RNA-Seq peripheral blood cyanotic congenital heart diseases

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Chronic permanent hypoxemia predisposes to mild elevation of liver stiffness

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World Journal of Gastroenterology 2014年第30期20卷 10564-10569页

作者： Mohamed Tahiri Abdenasser Drighil Yasmine Jalal Dounia Ghellab Wafaa Hliwa Haddad Fouad Wafaa Badre Ahmad Bellabah Rachida Habbal Rhimou Alaoui Department of Gastroenterology Ibn Rochd University Hospital Center of CasablancaCasablanca 20170Morocco Department of Cardiology Ibn Rochd University Hospital Center of CasablancaCasablanca 20170Morocco

AIM:To evaluate the impact of long term permanent hypoxemia noticed in patients with non operated congenital cyanogenic cyanotic cardiopathy on liver ***:We included ten adult patients with non operated inoperate cyanotic cardiopathy and ten matched patients for age and gender admitted to the gastroenterology department for proctologic diseases;Clinical and laboratory data were collected[age,gender,body mass index,oxygen saturation,glutamate oxaloacetate transaminase(GOT),glutamate pyruvate transaminase(GPT),glycemia and cholesterol].Measurement of hepatic stiffness by transient elastography was carried out in all patients using the Fibroscan *** patients underwent an echocardiography to eliminate congestive heart ***:Among the patients with cyanotic cardiopathy,median liver stiffness 5.9±1.3 kPa was greater than control group(4.7±0.4 kPa)(P=0.008).Median levels of GOT,GPT,gamma-glutamyltransferase,glycemia and cholesterol were comparable in cardiopathy and control *** regression analysis including age,gender,body mass index,oxygen saturation,GOT,GPT,glycemia,cholesterol showed that only oxygen saturation was related to liver stiffness(r=-0.63 P=0.002).CONCLUSION:Chronic permanent hypoxemia can induce mild increase of liver stiffness,but further studies are needed to explore the histological aspects of liver injury induced by chronic permanent hypoxemia.

关键词： Liver Cardiopathy Hypoxemia Stiffness cyanotic

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