Metabolic profile of heart tissue in cyanotic conaenital heart disease

作     者：Kai Chen Jiangping Song 

作者机构：State Key Laboratory of Cardiovascular DiseaseNational Center for Cardiovascular DiseasesFuwai HospitalCAMS and PUMCBeijingChina 

出 版 物：《中国循环杂志》 (Chinese Circulation Journal)

年 卷 期：2018年第33卷第S1期

页      面：123-123页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Cyanotic congenital heart disease(CCHD) birth anomaly non-cyanotic CHD(NCCHD) 

摘      要：Background Cyanotic congenital heart disease(CCHD)is one ofthe most common birth anomaly,in which chronic hypoxia is the basic pathophysiological *** in the protective mechanisms of cardiomyocytes to chronic hypoxia have the potential to provide novel treatment strategies for many *** is a study of metabolism at global level,which capture global biochemical events by assaying thousands of small molecules in tissues,followed by application of bioinformatics to define metabolomic signatures of the *** order to describe the features of metabolic remodeling of the heart of CCHD,we conducted our study on the effect of hypoxia on metabolism of human heart by using tissue from patients with CCHD compared with that from patients with non-cyanotic CHD(NCCHD).