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Recent advances on stimuli-responsive macromolecular magnetic resonance imaging (MRI) contrast agents

Science China Chemistry 2018年第9期61卷 1110-1122页

作者： Jinming Hu Shiyong Liu CAS Key Laboratory of Soft Matter Chemistry Hefei National Laboratory for Physical Sciences at the Microscale i Ch EM (Collaborative Innovation Center of Chemistry for Energy Materials) Department of Polymer Science and Engineering University of Science and Technology of China

Magnetic resonance imaging(MRI) has been extensively used in clinical diagnosis and currently over 30% MRI runs are performed in the presence of contrast agents. However, commercially available contrast agents originated from small molecules typically exhibit relatively low relaxivities and insufficient circulation time. Therefore, there is a long pursuit to develop new contrast agents with high relaxivities to discriminate pathological tissues from normal ones. Compared with small molecule MRI contrast agents, the incorporation of small molecule contrast agents into macromolecular scaffolds allows for constructing macromolecular MRI contrast agents, remarkably elevating the relaxivities due in part to increased rotational correlation time(τR). Moreover, if the macromolecular scaffolds are responsive to external stimuli, the MRI signals could be selectively switched on at the desired sites(e.g., pathological tissues), further intensifying the imaging contrast. In this feature article, we outline the recent achievements in the fabrication of stimuli-responsive macromolecular MRI contrast agents. Specifically, macromolecular contrast agents being responsive to acidic p H, redox potentials, and other stimuli including photoirradiation, pathogens, and salt concentration are discussed. These smart contrast agents could affect either longitudinal(T1) or transverse(T2) relaxation times of water protons or other nuclei(e.g.,19 F), exhibiting enhanced signals in pathological tissues yet suppressed signals in normal ones and displaying promising potentials in in vitro and in vivo MRI applications.

关键词： pH-responsive redox-responsive contrast agents magnetic resonance imaging

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A PIID-DTBT based semi-conducting polymer dots with broad and strong optical absorption in the visible-light region： Highly effective contrast agents for multiscale and multi-spectral photoacoustic imaging

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Nano Research 2017年第1期10卷 64-76页

作者： Jian Zhang Haobin Chen Ting Zhou Limei Wang Duyang Gao Xuanjun Zhang Yubin Liu Changfeng Wu Zhen Yuan Bioimaging Core Faculty of Health Sciences University of Macao Taipa Macao SAR 999078 China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Jilin 130012 China College of Optoelectronic Engineering Shenzhen University Shenzhen 518060 China College of Veterinary Medicine South China Agricultural University Guangzhou 510642 China Center for Drug Non-clinical Evaluation and Research Guangdong Biological Resources Institute Guangdong Academy of Sciences Guangzhou 510900 China

As a hybrid imaging technique, photoacoustic imaging （PAI） can provide multiscale morphological information of tissues, and the use of multi-spectral PAI （MSPAI） can recover the spatial distribution of chromophores of interest, such as hemoglobin within tissues. Herein, we developed a contrast agent that can very effectively combine multiscale PAI with MSPAI for a more comprehensive characterization of complex biological tissues. Specifically, we developed novel PIID-DTBT based semi-conducting polymer dots （Pdots） that show broad and strong optical absorption in the visible-light region （500-700 nm）. The performances of gold nanoparticles （GNPs） and gold nanorods （GNRs）, which have been verified as excellent photoacoustic contrast agents, were compared with that of the Pdots based on the multiscale PAI system. Both ex vivo and in vivo experiments demonstrated that the Pdots have better photoacoustic conversion efficiency at 532 nm than GNPs and showed similar photoacoustic performance with GNRs at 700 nm at the same mass concentration. Photostability and toxicity tests demonstrated that the Pdots are photostable and biocompatible. More importantly, an in vivo MSPAI experiment indicated that the Pdots have better photoacoustic performance than the blood and therefore the signals can be accurately extracted from the background of vascular-rich tissues. Our work demonstrates the great potential of Pdots as highly effective contrast agents for the precise localization of lesions relative to the blood vessels based on multiscale PAI and MSPAI.

关键词： nanoparticles polymer dots contrast agents photoacoustic imaging multiscale imaging multi-spectral imaging

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Nanoparticulate X-ray CT contrast agents

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Science China Chemistry 2015年第5期58卷 753-760页

作者： Wenya He Kelong Ai Lehui Lu State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences

X-ray computed tomography(CT) has been widely used as a powerful diagnostic tool in clinics because it can provide high-resolution 3D tomography of the anatomic structure based on the distinctive X-ray absorptions between different tissues. Currently, CT contrast agents are mainly small iodinated molecules, which suffer from drawbacks such as short blood- retention time, nonspecific in vivo biodistribution, and renal toxicity. Utilization of nanoparticles as potential CT contrast agents to overcome the aforementioned issues has advanced rapidly. In this mini review, we introduce current research efforts in the development of nanoparticulate CT contrast agents and discuss the challenges for additional breakthroughs in this field.

关键词： X-ray computed tomography (CT) contrast agents nanoparticles iodine

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Nanogels as contrast agents for Molecular Imaging

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Chinese Journal of Chemistry 2016年第6期34卷 547-557页

作者： Jianzhi Zhu Wenjie Sun Xiangyang Shi College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University Shanghai 201620 China

Nanogels （NGs） as soft nanosized materials have gained a variety of interests in biomedical fields. The versatile NG scaffolds with 3-dimensional spherical shape, high loading efficiency, tunable surface functionalization, and excellent biocompatibility afford their uses as carrier to load mono- or multi-mode molecular imaging contrast agents （CAs）. This review summarizes the synthesis routes and applications of NGs as CAs for molecular imaging applications including magnetic resonance （MR）, computed tomography （CT）, radionuclide, optical, and dual/mul- ti-modality imaging.

关键词： nanogels contrast agents MR imaging CT imaging radionuclide imaging optical imaging dual/multi-modality imaging

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Synthesis, Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging (MRI) contrast agents:Polylysine (Gd-DTPA/DOTA) with Pendent Galactose Moieties as Hepatocyte-targeting Groups

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Chinese Chemical Letters 1997年第2期8卷 157-160页

作者： Zhuo, RX Fu, YJ Liao, J WUHAN UNIV DEPT CHEMWUHAN 430072PEOPLES R CHINA

DTPA or DOTA ligand was introduced into the pendent amino groups of polylysine ( 268) by mono-mixed anhydride of DTPA or DOTA,and then translated with Gd-EDTA. The resultant polymer chelates were further reacted with 6-O-bromoacetyl-D-galactose to give liver-specific contrast agents for magnetic resonance imaging. These new polymer conjugates were characterized by FT-IR, ICP-AES, UV-Vis spectrophotometry and elemental analysis. Their in vitro spin-lattice relaxivity and body distribution in mice were investigated.

关键词： Gd-DTPA/DOTA with Pendent Galactose Moieties as Hepatocyte-targeting Groups contrast agents Relaxivity and Biodistribution of Novel Magnetic Resonance Imaging DTPA DOTA MRI

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Near-Infrared Fluorescence Imaging contrast agents for Clinical Research: Limitations and Alternatives

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Open Journal of Biophysics 2024年第1期14卷 73-77页

作者： Serigne Moussa Badiane Elhadji A. L. Bathily Fawrou Seye Louis A.D. Diouf Department of Health Sciences Gaston BERGER University Saint-Louis Senegal Department of Health Sciences Cheikh Anta DIOP University Dakar Senegal Cell Biology and Histology Health Sciences Department Gaston BERGER University Saint-Louis Senegal

Introduction: Near-infrared fluorescence imaging is a technique that will establish itself in the short term at the international level because it is recognized for its potential to improve the performance of surgical interventions, its moderate investment and operating costs and its portability. Although the technology is now mature, there is currently the problem of the availability of contrast agents to be injected IV. The aim of this methodology article is to propose an alternative solution to the need for contrast agents for clinical research, particularly in oncology. Methodology: They consist of coupling a fluorescent marker in the form of an NHS derivative, such as IR DYE manufactured in compliance with GMP, with therapeutic monoclonal antibodies having marketing authorization for molecular imaging. For a given antibody, the marking procedure must be the subject of a validation file on the final preparation filtered on a sterilizing membrane at 0.22 μm. Once the procedure has been validated, it would be unnecessary to repeat the tests before each clinical research examination. A check of the marking by thin-layer chromatography (TLC) and place it in a sample bank at +4˚C for 1 month of each injected formulation would be sufficient for additional tests if necessary. Conclusion: Molecular near-infrared fluorescence imaging is experiencing development, the process of which could be accelerated by greater availability of clinical contrast agents. Alternative solutions are therefore necessary to promote clinical research in this area. These methods must be shared to make it easier for researchers.

关键词： Fluorescence Imaging contrast agents Clinical Research

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Tumor microenvironment-responsive contrast agents for specific cancer imaging:a narrative review

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Journal of Bio-X Research 2020年第4期3卷 144-156页

作者： Xianwen Wang Xiaoyan Zhong Huali Lei Nailin Yang Xiang Gao Liang Cheng Institute of Functional Nano&Soft Materials(FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Department of Toxicology School of Public HealthJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric DiseasesMedical College The Second Affiliated Hospital of Soochow University SuzhouJiangsu ProvinceChina

Molecular imaging is of great significance for early diagnosis and timely treatment of cancer and disease,as well as basic medical and biological *** personalized cancer treatment has become increasingly popular,the demand for more advanced imaging technologies has also significantly *** advantage of differences between the tumor microenvironment and normal tissue cells,tumor microenvironment-responsive or"turn-on"contrast agents have a higher signal-to-noise ratio and lower background interference compared with"turn-off"probes,which can remarkably improve the performance of tumor ***,tumor microenvironment-responsive contrast agents can not only detect changes in the tumor microenvironment,but also have important significance for tumor diagnosis,prediction of invasion potential,evaluation of treatment effectiveness,planning of therapeutic regimens,and tumor ***,this review focuses on recent research progress of tumor microenvironment-responsive intelligent probes,and highlights future research directions of tumor microenvironment-responsive contrast agents for precision diagnostics.

关键词： cancer imaging cancer treatment contrast agents diagnosis tumor microenvironment

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Octapod iron oxide nanoparticles as high performance T2 contrast agents for magnetic resonance imaging

Octapod iron oxide nanoparticles as high performance T2 cont...

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第八届全国化学生物学学术会议

作者： Zhenghuan Zhao Jinhao Gao State Key Laboratory of Physical Chemistry of Solid Surfaces The Key Laboratory for Chemical Biology of Fujian Provinceand Department of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen University

Spherical superparamagnetic iron oxide nanoparticles have been developed as T-negative contrast agents for magnetic resonance imaging in clinical use because of their biocompatibility and ease of synthesis;however,the... 详细信息

关键词： Magnetite nanoparticles octapod relaxivity contrast agents

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Doped Inorganic Nanoparticles as Synergistically Enhanced T1-T2 Dual-Modal MRI contrast agents

Doped Inorganic Nanoparticles as Synergistically Enhanced T1...

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中国化学会第28届学术年会

作者： Zijian Zhou 1,Dengtong Huang 1,Zhenghuan Zhao 1,Jianfeng Bao 2,Zhong Chen 2,Jinhao Gao 1,* 1State Key Laboratory of Physical Chemistry of Solid Surfaces,The Key Laboratory for Chemical Biology of Fujian Province,and Department of Chemical Biology,College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005.2 Department of Electronic Science and Fujian Key Laboratory of Plasma and Magnetic Resonance,Xiamen University,Xiamen 361005.

＜正＞The combination of multiple imaging modalities can yield complementary diagnostic information and offer synergistic advantages over the single *** T1-T2 dual-modal strategy for magnetic resonance imaging

关键词： contrast agents inorganic nanoparticles T1-T2 dual-modal synergistic enhancement MRI

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Rational Design of High-Performance MRI contrast agents for Cancer Diagnosis in Living Subjects

Rational Design of High-Performance MRI Contrast Agents for ...

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第八届全国化学生物学学术会议

作者： Jinhao Gao State Key Laboratory of Physical Chemistry of Solid Surfaces The Key Laboratory for Chemical Biology of Fujian Provinceand Department of Chemical BiologyCollege of Chemistry and Chemical EngineeringXiamen University

Magnetic nanoparticles are attracting extensive interest for their ability to enhance the magnetic resonance contrast *** superparamagnetic iron oxide(SPIO) nanoparticles(e.g.,Feridex and Resovist)have been developed ... 详细信息

关键词： MRI contrast agents High performance Molecular imaging Cancer

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