Nanoparticulate X-ray CT contrast agents

作     者：Wenya He Kelong Ai Lehui Lu 

作者机构：State Key Laboratory of Electroanalytical Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2015年第58卷第5期

页      面：753-760页

核心收录：

学科分类：081702[工学-化学工艺] 08[工学] 0817[工学-化学工程与技术] 

基　　金：supported by the Jilin Province Youth Foundation(20130522131JH) the National Natural Science Foundation of China(21125521,21075117) the Hundred Talents Project of the Chinese Academy of Science 

主　　题：X-ray computed tomography (CT) contrast agents nanoparticles iodine 

摘      要：X-ray computed tomography(CT) has been widely used as a powerful diagnostic tool in clinics because it can provide high-resolution 3D tomography of the anatomic structure based on the distinctive X-ray absorptions between different tissues. Currently, CT contrast agents are mainly small iodinated molecules, which suffer from drawbacks such as short blood- retention time, nonspecific in vivo biodistribution, and renal toxicity. Utilization of nanoparticles as potential CT contrast agents to overcome the aforementioned issues has advanced rapidly. In this mini review, we introduce current research efforts in the development of nanoparticulate CT contrast agents and discuss the challenges for additional breakthroughs in this field.