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Expression and significance of pigment epithelium-derived factor and vascular endothelial growth factor in colorectal adenoma and cancer

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 670-686页

作者： Ye Yang Wu Wen Feng-Lin Chen Ying-Jie Zhang Xiao-Cong Liu Xiao-Yan Yang Shan-Shan Hu Ye Jiang Jing Yuan Digestive Diseases Chengdu Qingbaijiang District People's HospitalChengdu 610300Sichuan ProvinceChina Digestive Diseases Chengdu Second People’s HospitalChengdu 610000Sichuan ProvinceChina Graduate School Chengdu Medical CollegeChengdu 610000Sichuan ProvinceChina

BACKGROUND The incidence and mortality of colorectal cancer(CRC)are among the highest in the world,and its occurrence and development are closely related to tumor *** the balance between pigment epithelium-derived factors(PEDF)that inhibit angiogenesis and vascular endothelial growth factors(VEGF)that stimulate angiogenesis is broken,angiogenesis is out of control,resulting in tumor ***,it is very necessary to find more therapeutic targets for CRC for early intervention and later *** To investigate the expression and significance of PEDF,VEGF,and CD31-stained microvessel density values(CD31-MVD)in normal colorectal mucosa,adenoma,and *** In this case-control study,we collected archived wax blocks of specimens from the Digestive Endoscopy Center and the General Surgery Department of Chengdu Second People's Hospital from April 2022 to October *** cases of specimen wax blocks were selected as normal intestinal mucosa confirmed by electronic colonoscopy and concurrent biopsy(normal control group),50 cases of specimen wax blocks were selected as colorectal adenoma confirmed by electronic colonoscopy and pathological biopsy(adenoma group),and 50 cases of specimen wax blocks were selected as CRC confirmed by postoperative pathological biopsy after inpatient operation of general surgery(CRC group).An immunohistochemical staining experiment was carried out to detect PEDF and VEGF expression in three groups of specimens,analyze their differences,study the relationship between the two and clinicopathological factors in CRC group,record CD31-MVD in the three groups,and analyze the correlation of PEDF,VEGF,and CD31-MVD in the colorectal adenoma group and the CRC *** F test or adjusted F test is used to analyze measurement data ***-Wallis rank sum test was used between groups for ranked *** chi-square test,adjusted chi-square test,or Fisher's exact test were used to compare the rates betwe

关键词： Pigment epithelium-derived factors Vascular endothelial growth factor Microvessel density colorectal adenoma colorectal cancer Targeted therapy

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Long-term impact of artificial intelligence on colorectal adenoma detection in high-risk colonoscopy

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World Journal of Gastrointestinal Endoscopy 2024年第6期16卷 335-342页

作者： Kenneth W Chow Matthew T Bell Nicholas Cumpian Maryanne Amour Ryan H Hsu Viktor E Eysselein Neetika Srivastava Michael W Fleischman Sofiya Reicher Department of Medicine Harbor-UCLA Medical CenterTorranceCA 90502United States Department of Bioengineering Jacobs School of EngineeringUniversity of CaliforniaSan DiegoLa JollaCA 92093United States Department of Gastroenterology Harbor-UCLA Medical CenterTorranceCA 90502United States

BACKGROUND Improved adenoma detection rate(ADR)has been demonstrated with artificial intelligence(AI)-assisted ***,data on the real-world appli-cation of AI and its effect on colorectal cancer(CRC)screening outcomes is *** To analyze the long-term impact of AI on a diverse at-risk patient population undergoing diagnostic colonoscopy for positive CRC screening tests or *** AI software(GI Genius,Medtronic)was implemented into the standard proced-ure protocol in November *** was collected on patient demographics,procedure indication,polyp size,location,and *** screening outcomes were evaluated before and at different intervals after AI introduction with one year of *** We evaluated 1008 colonoscopies(278 pre-AI,255 early post-AI,285 established post-AI,and 190 late post-AI).The ADR was 38.1%pre-AI,42.0%early post-AI(P=0.77),40.0%established post-AI(P=0.44),and 39.5%late post-AI(P=0.77).There were no significant differences in polyp detection rate(PDR,baseline 59.7%),advanced ADR(baseline 16.2%),and non-neoplastic PDR(baseline 30.0%)before and after AI *** In patients with an increased pre-test probability of having an abnormal colonoscopy,the current generation of AI did not yield enhanced CRC screening metrics over high-quality *** the potential of AI in colonoscopy is undisputed,current AI technology may not universally elevate screening metrics across all situations and patient *** studies that analyze different AI systems across various patient populations are needed to determine the most effective role of AI in optimizing CRC screening in clinical practice.

关键词： Artificial intelligence Colonoscopy adenoma detection rate Screening colorectal adenoma

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Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma

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World Journal of Gastroenterology 2012年第6期18卷 557-562页

作者： Hyung Hun Kim You Sun Kim Yun Kyung Kang Jeong Seop Moon Department of Internal Medicine Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Department of Pathology Seoul Paik HospitalInje University College of MedicineSeoul 100-032South Korea Hyung Hun Kim Department of Internal Medicine Kosin University College of MedicineBusan 602-702South Korea

AIM： To investigate the expressions of leptin and per- oxisome proliferator-activated receptor y （PPARG） in relation to body mass index （BMI）. METHODS： We evaluated leptin and PPARG expres- sion in 30 adenomas over 1 cm in size by immunohisto- chemical staining. In addition, clinicopathologic features including BMI were assessed. RESULTS： PPARG and leptin expression showed a strong positive correlation （P = 0.035）. The average BMI of the leptin-positive group was higher than that of the leptin-negative group （25.4 ＋ 3.4 kg/m2 vs 22.6 ＋ 2.4 kg/m2, P = 0.018）, and leptin expression was sig- nificantly correlated with high BMI （P = 0.024）. Leptinexpression was more frequently observed in intermedi- ate/high grade dysplasia than in low grade dysplasia （P = 0.030）. However, PPARG expression was not cor- related with BMI and grade of dysplasia. CONCLUSION： BMI has influenced on the leptin ex- pression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.

关键词： Leptin Peroxisome proliferator-activated re-ceptor y Obesity Body mass index colorectal adenoma

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Measurement of biological age may help to assess the risk of colorectal adenoma in screening colonoscopy

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World Journal of Gastroenterology 2017年第37期23卷 6877-6883页

作者： Sang-Jung Kim Beom Jin Kim Hyun Kang Department of Internal Medicine Bundang Jesaeng Hospital Sungnam-si Department of Internal Medicine Chung-Ang University College of Medicine Department of Anesthesiology and Pain Medicine.Chung-Ang University College of Medicine

AIM To investigate the clinical utility of biological age(BA) measurement in screening colonoscopy for the detection of colorectal adenomas in the average-risk *** A consecutive series of asymptomatic subjects aged ≥ 30 years who underwent colonoscopy in routine check-ups were enrolled. colorectal adenoma was classified according to size, number, and location. BAs were calculated using the MEDIAGETM Biological Age Measurement *** A total of 2696 subjects were investigated(1876 men and 820 women). The mean chronological age(CA) was 46.0 years and the mean BA was 44.7 years. Metabolic syndrome(MS) was diagnosed in 218 subjects(8.1%). The prevalence of overall colorectal adenoma was 23.1%(622/2,696). When the subjects were divided into four groups based on BA(≤ 39 years; 40-49 years; 50-59 years; ≥ 60 years), the prevalence of colorectal adenoma was increased as BA increased(P colorectal adenoma located in the proximal colon was more prevalent in the BA-dominant group(BA-CA ≥ 5years) than the CA-dominant group(CA-BA ≥ 5 years)(P = 0.034). When the subjects were categorized into four groups according to MS and age gap between BA and CA, the incidence of colorectal adenoma increased with MS and BA-dominance(P colorectal adenoma in screening colonoscopy.

关键词： Chronological age Biological age colorectal adenoma Age gap

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Association between NAFLD and Risk of colorectal adenoma in Chinese Han Population

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Journal of Clinical and Translational Hepatology 2019年第2期7卷 99-105页

作者： Yuan Li Shousheng Liu Yuqiang Gao Huan Ma Shuhui Zhan Yan Yang Yongning Xin Shiying Xuan Department of Gastroenterology Qingdao Municipal HospitalQingdaoChina Department of Infectious Disease Qingdao Municipal HospitalQingdaoChina Central Laboratories Qingdao Municipal HospitalQingdaoChina Digestive Disease Key Laboratory of Qingdao QingdaoChina

Background and Aims:colorectal cancer is associated with non-alcoholic fatty liver disease(NAFLD)and other metabolic syndromes,such as obesity,abnormal blood glucose,and *** relationship of NAFLD and colorectal adenoma,which is the precursor of colorectal cancer,is worthy of *** aim of this study was to investigate the association between colorectal adenoma and NAFLD,colorectal adenoma and metabolic syndrome in a Chinese Han ***:This retrospective study analyzed the relationship between NAFLD and colorectal adenoma in 1089 patients in Qingdao municipal *** were divided into a colorectal adenoma group(n=267)and a control group(n=822).NAFLD and the controlled attenuation parameter(CAP)value were determined by abdominal ultrasound and ***:Patients with NAFLD in the colorectal adenoma group and the control group represented 142 cases(53.2%)and 360 cases(43.8%),*** mean CAP value in the colorectal adenoma group was significantly higher than that in the control *** values of body mass index,triglyceride,high-density lipoprotein cholesterol,aspartate aminotransferase,fasting plasma glucose,and uric acid were also significantly higher in the colorectal adenoma group than in the control *** logistic regression analysis showed that the sex,NAFLD,CAP,body mass index,triglyceride,aspartate aminotransferase,and fasting plasma glucose were significant risk factors for colorectal ***,NAFLD and CAP value were significant risk factors for colorectal adenoma in males but not in ***:NAFLD and metabolic syndrome were tightly associated with the risk of colorectal adenoma in this Chinese Han *** effect of NAFLD on colorectal adenoma was prominent in males rather than in females.

关键词： Non-alcoholic fatty liver disease(NAFLD) colorectal adenoma Metabolic syndrome Controlled attenuation parameter(CAP)

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Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies

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World Journal of Gastroenterology 2017年第10期23卷 1909-1919页

作者： Justyna Godos Antonio Biondi Fabio Galvano Francesco Basile Salvatore Sciacca Edward L Giovannucci Giuseppe Grosso Integrated Cancer Registry of Catania-Messina-Siracusa-Enna Azienda Ospedaliero Universitaria Policlinico Vittorio Emanuele Department of General Surgery Section of General Surgery and OncologyUniversity of Catania Department of Biomedical and Biotechnological Sciences University of Catania Department of Epidemiology Harvard TH Chan School of Public Health Department of Nutrition Harvard TH Chan School of Public Health Channing Division of Network Medicine Department of MedicineBrigham and Women’s Hospital and Harvard Medical School

To perform a meta-analysis of observational studies on inflammatory markers levels and occurrence of colorectal *** and EMBASE databases were searched until March 2016 for the articles reporting on the circulating levels of inflammatory markers, including: C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) and risk of colorectal adenoma. Random-effects models were used to calculate summary odds ratios (ORs) with 95%CIs for the highest vs lowest category of exposure. Heterogeneity was assessed by using the Q test and I2 statistic. Subgroup analyses were also performed to test for potential source of *** total of 14 case-control studies were included. Ten studies on CRP including a total of 3350 cases and 4168 controls showed non-significant summary (OR = 1.23, 95%CI: 0.98-1.54; I2 = 54%, Pheterogeneity = 0.01) in the general analysis, but significant increased odds when considering only advanced adenoma (OR = 1.59, 95%CI: 1.09-2.32; I2 = 44%, Pheterogeneity = 0.15). Subgroup and stratified analyses revealed a potential influence of smoking status and aspirin use on the association between CRP levels and colorectal adenoma. Five studies examined the association between circulating levels of TNF-α and colorectal adenoma risk, including a total of 1,568 cases and 2,832 controls. The summary OR for the highest vs the lowest category of exposure was 1.00 (95%CI: 0.77-1.29). The relationship between circulating IL-6 levels and colorectal adenoma risk was investigated in 7 studies including a total of 1936 cases and 3611 controls. The summary OR for the highest vs the lowest category of exposure was 1.19 (95%CI: 0.92-1.55).CONCLUSIONSummary of current evidence suggests a positive association of CRP levels and advanced colorectal adenoma risk. The role of potential confounding factors should be further evaluated.

关键词： Inflammatory markers Meta-analysis colorectal adenoma C-reactive protein Tumor necrosis factor-alpha Interleukin-6

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Current and future molecular diagnostics in colorectal cancer and colorectal adenoma

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World Journal of Gastroenterology 2014年第14期20卷 3847-3857页

作者： Andy Hin-Fung Tsang Ka-Ho Cheng Apple Siu-Ping Wong Simon Siu-Man Ng Brigette Buig-Yue Ma Charles Ming-Lok Chan Nancy Bo-Yin Tsui Lawrence Wing-Chi Chan Benjamin Yat-Ming Yung Sze-Chuen Cesar Wong Department of Health Technology and Informatics Faculty of Health and Social SciencesHong Kong Polytechnic University Department of Surgery Prince of Wales Hospital State Key Laboratory in Oncology in South China Sir Y K Pao Centre for CancerDepartment of Clinical OncologyHong Kong Cancer Institute and Prince of Wales HospitalThe Chinese University of Hong Kong

colorectal cancer(CRC)is one of the most prevalent cancers in developed *** the other hand,CRC is also one of the most curable cancers if it is detected in early stages through regular colonoscopy or *** CRC develops slowly from precancerous lesions,early detection can reduce both the incidence and mortality of the *** occult blood test is a widely used non-invasive screening tool for *** fecal occult blood test is simple and cost-effective in screening CRC,there is room for improvement in terms of the accuracy of the *** dysregulations have been found to play an important role in CRC *** better understanding of the molecular basis of CRC,there is a growing expectation on the development of diagnostic tests based on more sensitive and specific molecular markers and those tests may provide a breakthrough to the limitations of current screening tests for *** this review,the molecular basis of CRC development,the characteristics and applications of different non-invasive molecular biomarkers,as well as the technologies available for the detection were *** review intended to provide a summary on the current and future molecular diagnostics in CRC and its pre-malignant state,colorectal adenoma.

关键词： colorectal cancer colorectal adenoma Molecular diagnostics Fecal occult blood test Non-invasive

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Expression of adipokine ghrelin and ghrelin receptor in human colorectal adenoma and correlation with the grade of dysplasia

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1708-1720页

作者： Sanja Stojsavljevic-Shapeski Lucija Virovic-Jukic Davor Tomas Marko Duvnjak Vedran Tomasic Davor Hrabar Dominik Kralj Ivan Budimir Neven Barsic Neven Ljubicic Division of Gastroenterology Department of Internal Medicine«Sestre Milosrdnice»University Hospital CenterZagreb 10000Croatia Department of Internal Medicine School of MedicineUniversity of ZagrebZagreb 10000Croatia Ljudevit Jurak Department of Pathology «Sestre Milosrdnice»University Hospital CenterZagreb 10000Croatia Department of Pathology School of MedicineUniversity of ZagrebZagreb 10000Croatia

BACKGROUNDGhrelin is an adipokine that plays an important role in energy balance. Expressionof ghrelin and ghrelin receptor has been investigated in different tissues andtumors. Studies regarding expression of ghrelin and ghrelin receptor in colorectaltumors are scarce and no data on expression of ghrelin and its receptor incolorectal adenomas has been published. Ghrelin and ghrelin receptor werehighly expressed in colon carcinoma cells while expression was decreased in lessdifferentiated tumors, presuming that ghrelin might be important in early phasesof *** investigate the expression of ghrelin and ghrelin receptor in human colorectaladenomas and adjacent colorectal *** this prospective study (conducted from June 2015 until May 2019) we included92 patients (64 male and 28 female) who underwent polypectomy for colorectaladenomas in the Department of Gastroenterology and Hepatology, “Sestre milosrdnice” Clinical Hospital Center in Zagreb, Croatia. After endoscopicremoval of colorectal adenoma, an additional sample of colon mucosa in theproximity of the adenoma was collected for pathohistological analysis. adenomaswere graded according to the stage of dysplasia, and ghrelin and ghrelin receptorexpression were determined immunohistochemically in both adenoma andadjacent colon tissue using the polyclonal antibody for ghrelin (ab150514,ABCAM Inc, Cambridge, United States) and ghrelin receptor (ab48285, ABCAMInc, Cambridge, United States). Categorical and nominal variables were describedthrough frequencies and proportions and the difference between specific groupswere analyzed with Fisher’s and Fisher-Freeman-Halton’s method ***'s rank correlation coefficient was determined for correlation ofexpression of ghrelin and ghrelin receptor in adenoma and adjacent colon tissuewith the grade of adenoma *** 92 patients with colorectal adenoma 43 had adenomas with high-gradedysplasia (46.7%). High expression of ghre

关键词： Ghrelin Ghrelin receptor Adipokines colorectal adenoma colorectal adenoma dysplasia Large intestine

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The first year follow-up after colorectal adenoma polypectomyis important: A multiple-center study in symptomatichospital-based individuals in China

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Frontiers of Medicine 2010年第4期4卷 436-442页

作者： Qin-Yan GAO Hui-Min CHEN Jian-Qiu SHENG Ping ZHENG Cheng-Gong YU Bo JIANG Jing-Yuan FANG Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai Institute of Digestive DiseaseShanghai 200001China Department of Gastroenterology PLA.The Military General Hospital of BeijingBeijing 100700China Shanghai 1st Hospital Shanghai Jiao Tong UniversityShanghai 200001China Department of Gastroenterology The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Gastroenterology Nanfang HospitalNanfang UniversityGuangzhou 510515China

The recurrence of colorectal adenoma(CRA)is *** there are guidelines for colonoscopy surveillance after polypectomy in other countries,little is known about its recurrence rate and recurrence peak,especially in *** aim of the present research is to investigate how long after polypectomy follow-up should take and to analyze risk factors of recurrence.1208 patients who received polypectomies fromﬁve clinical research centers in four regions of China(Shanghai,Guangzhou,Nanjing and Beijing)were *** were divided into 4 groups:group A(follow-up≤1 year after poly-pectomy),group B(follow-up 2–3 years after polypect-omy),group C(follow-up 4–5 years after polypectomy),and group D(follow-up>5 years after polypectomy).The sex,age,adenoma location,size,number,and pathological characteristics were *** the whole,the recur-rence rate was 59.46%in group A,61.09%in group B,78.07%in group C,and 87.12%in group D,which indicated an increased tendency with a prolonged follow-up *** was a signiﬁcant difference between group A and C or D,and between group B and C or D(P<0.01),but there was no statistical difference between group A and ***,the recurrent patients in theﬁrst year had a recurrence rate of 97.33%in theﬁrst three years(59.46/61.09),which means that the peak of recurrence was almost entirely concentrated in theﬁrst *** recurrence rate was higher in males and the *** risk factors included multiple numbers,villous feature,high-grade dysplasia of medium or smaller size and location in the distal *** conclusion,the peak of recurrence was almost totally concentrated in theﬁrst year;meanwhile,theﬁrst year follow-up is of critical importance in *** may not be necessary to do the follow-up examination during the second and third years,but after three years,another colonoscopy should be undertaken.

关键词： colorectal adenoma polypectomy follow-up recurrence risk factor

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Association between measures of obesity and colorectal adenoma

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Chinese Medical Journal 2011年第22期124卷 3711-3715页

作者： KIM You Joung LEE Kang-moon CHUNG Woo Chul PAIK Chang Nyol JUNG Sung Hoon Division of Biostatistics Graduate School of Public Health Seoul National University Seoul 110-799 Korea

Background Few studies have used body mass index （BMI）, waist-to-hip ratio （WHR） and waist circumference （WC） at the same time to investigate the association between obesity and colorectal adenoma. This study examined the strength of association between colorectal adenoma and obesity using not only BMI, but also WHR and WC. Methods Subjects of this study included 1322 asymptomatic patients who underwent colonoscopy for cancer screening from January 2006 to June 2008. Anthropometric measurements, blood test results, and a self-administered questionnaire from each subject were analyzed. Results Four hundred and fourteen adenoma cases were identified in 1322 subjects. Using univariate analysis, the prevalence of adenoma was associated with BMI and WHR and was higher among the abdominal obesity group using WC guidelines of the Korean Society for the Study of Obesity, but not using WC guidelines of the International Diabetes Federation. In multiple Logistic regression analysis, general obesity （BMI 〉25 kg/m2） increased the risk of colorectal adenoma （odds ratio （OR）, 1.43; 95% confidence interval （CO, 1.05-1.94）. Also, abdominal obesity by the WC cutoffs and the highest WHR percentile group （WHR 〉0.95） were significantly associated with adenoma. Among three measures of obesity, however, only BMI had a persistent association with adenoma after adjusting reciprocally for BMI, WC, and WHR （OR, 1.30; 95% CI, 1.02-1.80; and 1.49; 1.06-2.10, adjusted for WC and WHR, respectively）. Conclusion The data suggest that general obesity is associated with an increased risk of colorectal adenoma.

关键词： body mass index colorectal adenoma obesity

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