Association between NAFLD and Risk of Colorectal Adenoma in Chinese Han Population

作     者：Yuan Li Shousheng Liu Yuqiang Gao Huan Ma Shuhui Zhan Yan Yang Yongning Xin Shiying Xuan 

作者机构：Department of GastroenterologyQingdao Municipal HospitalQingdaoChina Department of Infectious DiseaseQingdao Municipal HospitalQingdaoChina Central LaboratoriesQingdao Municipal HospitalQingdaoChina Digestive Disease Key Laboratory of QingdaoQingdaoChina 

出 版 物：《Journal of Clinical and Translational Hepatology》 (临床与转化肝病杂志（英文版）)

年 卷 期：2019年第7卷第2期

页      面：99-105页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(31770837) the Qingdao People's Livelihood Science and Technology Plan(18-6-1-68-nsh) 

主　　题：Non-alcoholic fatty liver disease(NAFLD) Colorectal adenoma Metabolic syndrome Controlled attenuation parameter(CAP) 

摘      要：Background and Aims:Colorectal cancer is associated with non-alcoholic fatty liver disease(NAFLD)and other metabolic syndromes,such as obesity,abnormal blood glucose,and *** relationship of NAFLD and colorectal adenoma,which is the precursor of colorectal cancer,is worthy of *** aim of this study was to investigate the association between colorectal adenoma and NAFLD,colorectal adenoma and metabolic syndrome in a Chinese Han ***:This retrospective study analyzed the relationship between NAFLD and colorectal adenoma in 1089 patients in Qingdao municipal *** were divided into a colorectal adenoma group(n=267)and a control group(n=822).NAFLD and the controlled attenuation parameter(CAP)value were determined by abdominal ultrasound and ***:Patients with NAFLD in the colorectal adenoma group and the control group represented 142 cases(53.2%)and 360 cases(43.8%),*** mean CAP value in the colorectal adenoma group was significantly higher than that in the control *** values of body mass index,triglyceride,high-density lipoprotein cholesterol,aspartate aminotransferase,fasting plasma glucose,and uric acid were also significantly higher in the colorectal adenoma group than in the control *** logistic regression analysis showed that the sex,NAFLD,CAP,body mass index,triglyceride,aspartate aminotransferase,and fasting plasma glucose were significant risk factors for colorectal ***,NAFLD and CAP value were significant risk factors for colorectal adenoma in males but not in ***:NAFLD and metabolic syndrome were tightly associated with the risk of colorectal adenoma in this Chinese Han *** effect of NAFLD on colorectal adenoma was prominent in males rather than in females.